NDLI: The cumulative plot of power spectral analysis of heart rate variability assesses the kinetics of action of cholinergic drugs in rats

Content Provider	IEEE Xplore Digital Library
Author	Perlstein, I. Hoffman, A.
Copyright Year	2000
Description	Author affiliation: Sch. of Pharm., Hebrew Univ., Jerusalem, Israel (Perlstein, I.)
Abstract	A new approach to assess autonomic nervous system (ANS) activity and its response to drug action is presented. The authors' approach is based on using a cumulative plot of data obtained by power spectral analysis (PSA) of heart rate variability (HRV), in defined frequency bands, during short time epochs in rats. The substantial temporal variability in power evolving from the constant balancing nature of the ANS activity is minimized by this approach and produces a measurable index of ANS activity vs. time. The cumulative plot emphasizes the temporal response pattern of different components of the ANS and thereby facilitates the investigation of the kinetics of action of drugs affecting the ANS. The authors used this method to measure the activity of cholinergic drugs in freely moving Sabra rats. The pharmacodynamic (PD) data obtained by this method was combined with the drug concentration versus time (PK) profile to enable PK/PD modeling of the kinetics of the parasympathetic effect.
Starting Page	260
Ending Page	261
File Size	207220
Page Count	2
File Format	PDF
ISBN	0780364651
ISSN	1094687X
DOI	10.1109/IEMBS.2000.900723
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2000-07-23
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Spectral analysis Heart rate variability Kinetic theory Drugs Rats Autonomic nervous system Frequency Power measurement Power system modeling Heart rate
Content Type	Text
Resource Type	Article

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