NDLI: Free Surface Coating Flows of Non-Newtonian Gels: 3-D Numerical Simulation of Gravity-Induced Flow

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Vitaly, O. Kheyfets Sarah, L. Kieweg
Copyright Year	2007
Abstract	Developing a mechanism capable of protecting the vaginal or rectal epithelium from sexually transmitted pathogens can be an effective tool in the prevention of HIV infection [1]. One such tool can come in the form of a microbicide gel, used to provide a physical barrier and act as a delivery vehicle for its active ingredient [1]. In order for the microbicide to be an effective barrier and delivery vehicle it must have the capability to coat the epithelium for a specific amount of time and sustain its structural integrity under the influence of gravity and other perturbation forces. In addition, to be used as a drug delivery vehicle the microbicide must serve the following functions: coat the surface completely without leaving any of the surface exposed, stay on the surface while influenced by external forces such as gravity and squeezing, and must be able to contain potent concentrations of one or more active microbicidal ingredients.
Sponsorship	Bioengineering Division
Starting Page	531
Ending Page	532
Page Count	2
File Format	PDF
ISBN	0791847985
DOI	10.1115/SBC2007-176696
Conference Proceedings	ASME 2007 Summer Bioengineering Conference
Language	English
Publisher Date	2007-06-20
Publisher Place	Keystone, Colorado, USA
Access Restriction	Subscribed
Subject Keyword	Drug delivery systems Computer simulation Gravity (force) Coating processes Coatings Flow (dynamics) Vehicles
Content Type	Text
Resource Type	Article

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