NDLI: Effects of Steady Spatial Wall Shear Stress Gradients on Endothelial Cell Morphology in Three-Dimensional Models

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Synergistic Moments at the Hip and Knee Joints Are Altered in Post-Stroke Hemiplegic Gait

Estimation of Corrective Changes in Muscle Activation Patterns for Stroke Patients During FES Intervention

Concurrent Simulations of Musculoskeletal Movements and Tissue Deformations

The Characterization of Age-Related Human Cortical Bone Porosity, Water Distribution Changes by Nuclear Magnetic Resonance

Stability of Stepping Movements in the Frontal Plain: A Biomechanical Model

Simulation-Guided Stimulation for Paretic Ankle Muscles During Stroke Gait

Simulating the Independent Effects of Muscle Fiber Type Composition on Vertical Jumping Performance

Comparison of Muscle Function in 2D and 3D Walking Simulations

Influence of Walking Speed and Severity of Knee Osteoarthritis on Medial Compartment Loading

Resultant Carpal Kinematics With Respect to Muscle Force Application

Hand Grasping Kinematics

Changes in Camera Visibility Affect Measured Marker Motion

Optimal Estimation of Dynamically Consistent Kinematics and Kinetics for Forward Dynamic Simulations

Design and Evaluation of an Adaptive Ground Contact Model

Muscle Mechanical Work Adaptations With Increasing Walking Speed

Passive Joint Coupling in the Forearm, Wrist, and Hand

Model-Based FES Muscle Selection for Restoring Arm Movement in High SCI

On the Use of Induced End Effector Force Analysis for Determining Muscle Roles During Movement

Assessing Laxity Characteristics of Hyperextension Knee in Healthy Young Females Using a Knee Ligament Arthrometer

Analysis of the Tibio-Femoral Contact Point in Total Knee Replacement Using a Marker Based Motion Analysis System

Tissue Mechanics Lab: Pros and Cons of an Inquiry Approach for Juniors

Challenge to Biomedical Education Systems for Engineers: REDEEM and ESTEEM Projects

Desorption Electrospray Ionization Using a Porous Alumina Surface

In-Vitro Evaluation of Hot-Film Anemometry Using a Sensor-Tipped Coronary Guide-wire

Zinc Superparamagnetic Iron Oxide Nanoparticles for Use as MRI Contrast Agents

Numerical and Theoretical Analysis of the Ion Transport Around a Completely Polarizable Electrode Under AC for Use in Microfluidics

Photonic Crystal Sensors for the Rapid Detection of Myocardial Ischemia

Increased Biocompatibility of Common MEMS Substrates With Solution Phase Coupled Poly(ethylene glycol) Films

Microfluidics Bioreactor: A Platform for Studying Capillary Morphogenesis in Response to Biochemical and Biophysical Cues

Directing Neurite Growth in 3D Collagen Scaffolds With Gradients of Mechanical Properties

Opto-Electric Biosensor to Examine In Vitro Toxicity Stimuli to Endothelial Cell Motility and Morphology

BioMEMS Platform for Electromechanical Stimulation of Cell Culture

Learning by Tension

Quantification of Heterogeneity in Desiccating Droplets

Desiccation Response of Geobacter sulfurreducens

Intermolecular Multiple Quantum MR Thermography

A Multi-Zone Finite Element Model for Radiofrequency Ablation of an Infarcted Cardiac Tissue

Development of Quantum Dot-Embedded Nanoparticles for Biothermal Imaging

Comparison of Thermal and Non-Thermal Ablation of Tumor Using Focused Short Pulse Laser Beam

Thermal Damage Distribution in Human Cornea Following Thermal Keratoplasty: An FTIR Study

Non-Thermal Dental Ablation Using Ultra-Short Pulsed Near Infrared Laser

Thermoregulation in Humans: Results From an Anatomically-Based, High-Resolution Voxelized Model

Effects of Glycerol on the Thermal Properties of Phosphate Buffered Saline and Porcine Liver at Subzero Temperatures

Thermal ‘Fingerprinting’ of Cells Using FTIR

Thermal Therapy Protocols for Benign Prostatic Hyperplasia

Temperature Rise in Tissue Mimicking Material During HIFU Procedures

Transport Characteristics of a Novel Local Drug Delivery System Using Nordihydroguaiaretic Acid (NDGA)-Polymerized Collagen Fibers

Two Methods of Determining [3H]Dexamethasone Distribution in Rat Subcutaneous Tissue

Phospholipid Encapsulation and Surface Functionalization of Superparamagnetic Iron Oxide Nanoparticles for Molecular Magnetic Resonance Imaging: Effects on Spin-Spin Proton Relaxation

Effect of Active Transport and Loss to Choroidal Blood Flow on Transscleral Drug Delivery to the Posterior Eye

Flow and Convective Dispersion in the Conductive Airways of the Human Lung

Investigation of Drug Release From Biodegradable PLG Microspheres: Experiment and Theory

Fluid and Particle Transport in an In-Vitro Model of an Expanding/Contracting Human Alveolus

Numerical Simulation of Blood-Wall Albumin Transport in a Realistic Human Right Coronary Artery

A Confined Compression Technique for Hydraulic Conductivity Measurement in Soft Tissues

Effects of Improved Near-Wall Modeling on Micro-Particle Deposition in Oral Airway Geometries

Pharmacokinetics of Encapsulated Paclitaxel: Multi-Probe Analysis With PET

Closed Loop Glycemic Control in Critically Ill Patients: Feasibility Study and Experimental Design

Dynamics of Magnetic Drug Targeting in Cardiovascular Flows

Computational Model of Interstitial Transport in the Rat Brain Using Diffusion Tensor Imaging

Understanding EHDA and Protein Stability

Depth Dependent Diffusivity Profile in Bovine Articular Cartilage: Comparing Transverse and Axial Diffusivities

Soft Filaments Circulate Longer Than Spherical Particles - Shape Effects in Flow and Drug Delivery

Intraluminal Thrombus in AAA Wall Stress Analysis

Prediction of Arterial Failure Based on a Microstructural Bi-Layer Fiber-Matrix Model With Softening

Nonuniform Circumferential Deformation of the Abdominal Aorta: A Cross-Species Comparison

Gel Based Mechanical Phantom of Stenotic Coronary Artery

Engineering Vein Grafts Using an External Electrospun Biodegradable Polymer Wrap to Gradually Impose Arterial Circumferential Wall Stress Over Time

The Impact of an Abdominal Aortic Aneurysm on Aortic Wave Reflection

Development of a Wavelet Analytical Tool for Isolating and Evaluating Cavitation-Induced Hemolysis Generated During Mechanical Heart Valve Closure

Effect of Deformation Rate on the Mechanical Properties of Rectangular and Cruciform Arterial Samples: Uniaxial and Biaxial Testing

Non Invasive Assessment of Leaflet Deformation in Heart Valve Tissue Engineering

Stress Dependent Collagen Fibril Diameter Distribution in Human Aortic Valves

Two-Dimensional Simulation of Platelet Activation in the Hinge Region of a Mechanical Heart Valve

Inverse Characterization of Nonlinear Anisotropic Mechanical Properties of Engineered Cardiovascular Tissues Using a Spherical Indentation Test

Different Strains of Mice Exhibit Different Aortic Arch Geometry and Plaque Distribution: A Fluid Dynamic Effect

Preliminary Murine Aortic Tissue Material Properties From Pressure-Diameter Experiments

Measurement of In-Vivo Pulmonary Vascular Impedance in Two Animal Models of Pulmonary Hypertension

Fiber-Based Constitutive Model of Myocardial Scar Tissue

Wall Shear Stress Change Due to Arterial Wall Stiffness; Fluid-Solid Interactions Study

Structural Properties of Human Cerebral Arteries as Assessed by a Constituent-Based Biomechanical Model

A Structural Strain Energy Function for Vascular Tissue Considering Elastin Anisotropy

Effects of Reduced Compliance on Endothelial Functionality With Regards to Inflammation and Adhesion

Surface Strains in the Looping Embryonic Chick Heart Measured Using Optical Coherence Tomography

Hemodynamics in Human Abdominal Aortic Aneurysms During Rest and Simulated Exercise

Phenomenological Test Method to Assess of Material Symmetry in Thick Soft Tissues

Coronary Artery Wall Strain Estimation From Clinical IVUS Images

The Critical Buckling Pressure of Arteries

Effect of Pulse Pressure on the Vasomotor Function of Arteries

Treatment of Cerebral Aneurysms With Flow Divertors: Long Term Results in an In Vivo Model

Vulnerable Plaque Rupture Due to Stress Concentration Around Microcalcifications in the Thin Fibrous Cap

Temperature Measurement of Advanced Murine Atherosclerotic Plaques

A New Non-Invasive Method for Assessing the Intrinsic Active Strength of Human Left Ventricular Tissue

Three Dimensional Fluid Mechanics of the Sinus of Valsalva With a Bileaflet Mechanical Heart Valve

Culture Medium With Blood Analog Mechanical Properties

A Poroviscoelastic Model of Intraluminal Thrombus From Abdominal Aortic Aneurysms

Dynamics of Arterial Remodeling in Response to a Sustained Step Change in Blood Flow Using a Constituent-Based Model

Reduction of Intra-Aneurysmal Kinetic Energy by Intralumenal Flow Diverting Devices

Evolution of Scar Mechanical Properties During Myocardial Infarct Healing in Rat

Biaxial Testing of Human Pericardium: A Comparative Study of Fixed and Fresh Tissue

A Two Dimensional Phenomenological Model for Damage of Arteries

Platelet and Shear Stress Interactions Within Asymmetric Stenotic Arteries

The Effects of Vasoactive Agents on Impedance Measures in the Pulmonary Circulation of Mice

One Dimensional Model of the Systemic Arterial Tree Including Cerebral Circulation

Structural Mechanism for Alteration of Collagen Gel Mechanics by Glutaraldehyde Crosslinking

Changes in Vascular Viscoelasticity Caused by Smooth Muscle Cell Tone and Pressurization Frequency

Collocation of Macrophages and Mechanical Stress in Human Coronary Atherosclerotic Plaque

A Comparative Study of Mechanical Properties of Fresh and Elastic-Network Only Proximal Artery Tissues

Effects of Arterial Geometry on Inflow Rate Into Cerebral Aneurysms on Curved Arteries

The Role of Proteoglycans on Residual Stresses in the Aorta

Measurement of Coronary Artery Wall Strain In Situ Using IVUS

MMP-2 and -9 Collocate With High Stresses Predicted Using Heterogeneous Mechanical Model of Arteries

Strength of Porcine Carotid Arteries As a Function of Strain Rate and Storage Time

Development of a Thrombus Mimic in Abdominal Aortic Aneurysms

Wall Deformation, Wall Shear Stress and Atherosclerosis Around the Intercostal Ostia of C57 Mice

Turbulent vs. Vortex Ring Energy Losses in the Left Ventricle

The Digital Leaflet: Quantitative Image Analysis and 3-D Digital Reconstruction of the Aortic Valve Leaflet

Biological Markers of Atherogenesis Correlate With Both Shear and Mural Stress in Perfused Arterial Segments Exposed to Cyclic Axial Stretching Ex Vivo

Aortic Valve Interstitial Cell Viscoelasticity

Devlopment of a Cell Coculture Microfluidic Shear Device for Mechano-Transmission Study

Computational Study on the Effects of Peripheral Vessel Network on Blood Flow in the Arterial Circle of Willis

Circumferential Variation of Mechanical Properties of Ascending Aorta (AA): A Comparative Study of Healthy and Dilated AA

Multiscale Fluid-Structure Simulations of the Aortic Valve

In Vivo Dynamic Strains of the Mitral Valve Annulus

Mesenchymal Stem Cell Injection After Myocardial Infarction Improves Myocardial Compliance

Contribution of Elastin to the Mechanical Properties of Arterial Tissues

3d Reconstruction and Nonlinear Finite Element Analysis of the Embryonic Left Ventricle

A Theoretical Model for Saccular Cerebral Aneurysm Growth: Deformation and Stress Analysis

Force/Torque Field Generation to Obtain Local Properties within Soft Hydrogels

Viscoelastic Finite-Element Modelling of Cell Deformation in an Optical Stretcher

In Situ Transient Deformation of Chondrocytes Under Unconfined Compression: Experimental Measurements and Triphasic Finite Element Model

Simulation of the Coupling of Cell Contractility and Focal Adhesion Formation

Cytoskeletal Bundle Mechanics

Vascular Smooth Muscle Cell Mechanics During Cyclic Stretch: Effect of Serum and a Serum Substitute

Micromechanical Analysis of Tissues: The Effect of Cell Adhesion to Extra Cellular Matrix

Stretch-Activated Calcium Signal Propagation Following Mechanical Stimulation of Focal Adhesions

Modeling of Stress Fiber Organization in Cyclically Stretched Cells

Using Mechanical Environment to Enhance Stem Cell Transplantation in Muscle Regeneration

The Role of Microtubule Organization in Chondrocyte Response to Osmotic Loading

On the Cytoskeleton and Soft Glassy Rheology

Surfactant Spreading on a Thin Film Is Sensitive to Film Thickness: Implications for In Vivo Pulmonary Systems Versus In Vitro Scenarios

Numerical Simulation of a Suspension of Swimming Micro-Organisms

Measurement of Erythrocyte Motions in Microchannels by Using a Confocal Micro-PTV System

Effects of Fluid Shear Stress on Endothelial Cell Invasion Into Three-Dimensional Matrices

Effect of the Red Blood Cells on the Primary Thrombus Formation

Multi-Scale Models of Epithelial Cell Injury and Detachment During Microbubble Flows

Relationship Between Lumbar Disc Injury and Manual Lifting: A Finite Element Model Study

Role of Mechanical Feedback in Restoration of Normal Cardiac C-Looping Following Perturbed Loading

Predicting the Stresses and Displacements in Femoral Intramedullary Nails and Screws Using a Finite Element Model

Real Time Techniques for Nonlinear Tissue Deformation in Surgical Simulation

The Effect of Instrumentation With Different Mechanical Properties on the Pig Spine During Growth: Finite Element Analysis

Acoustic Vibration and Mechanical In Vivo Analysis of the Hip Joint After a Total Hip Arthroplasty

Dynamic Simulation of Red Blood Cells/Platelet Interaction in Arteriolar Blood Flow

The Effects of Varying Frictional Contact Boundary Conditions in Finite Element Analysis of Mandibular Parasymphyseal Fracture

Finite Element Analysis of Clinical Pressure-Flow Waveforms in a Collapsed Respiratory Airway

Maximum Principal Strains in the Glenohumeral Capsule During a Clinical Exam: A Validated Finite Element Model

Numerical and Experimental Study of a Novel Phase Contrast Technique: Self Reference Phase-Contrast Magnetic Resonance Imaging

A New Hypothesis for Human Atherosclerotic Plaque Progression Based on Serial In Vivo MRI and Computational Modeling Method

On Coupling a Lumped-Parameter Heart Model With a Three-Dimensional Finite Element Model of the Aorta

Contralateral Boundary Conditions Affect the Biomechanical Response of the Pubic Symphysis During Pelvic Side Impacts

Numerical and Experimental Analysis of Articular Chondrocyte Deformation: Calibration of a Multiscale Finite Element Model

Nonlinear Material Parameter Estimation Using Inverse Finite Element Analysis

Interaction Between Bone Cement Cracking and Non-Slip Implant Interfaces

The Influence of Different Parameters of Remodeling Rule on the Resultant Density Distribution of the Proximal Femur

Image- and Numerics-Based Analysis of Constitutive Properties of Cellular Structures

A Structural, Kinetic Model of Soft Tissue Thermomechanics

Effects of Compression on Distributions of Oxygen and Lactate in Intervertebral Disc

Computational Analysis of Atherosclerotic Plaque Vulnerability Due to Hemodynamic Effects

A Structural-Based Constitutive Model for Valvular Tissues Under Generalized Deformation

Development of a Finite Element Model to Predict Gap Displacement at Fracture Bridged Using Distal Femur Periarticular Locking Plate

Fracture Mechanics of Architecture Dependent Fracture in Trabecular Bone Using the Cohesive Finite Element Method

A Simulation Study on the Growth of Cerebral Aneurysms

Bottom-Up Mesoscale Model of Microtubule

Increases in the Elastic Modulus of Trabeucular Bone Tissue Leads to More Rapid Perforation of Trabeculae in Osteoporotic Bone

An Assessment of Primary Blast Injury in Human Brains: A Numerical Simulation

Investigation of Osteoclast Resorption Mechanisms in a Hybrid Cellular Automaton Model of Bone Remodeling

The Effect of Permeability of Cartilage Superficial Zone on the Behavior of Stress Relaxation and Creep of Human Ankle Joint

Biomechanical Effect of Lumbar Disc Degeneration Under Flexion/Extension: A Finite Element Model Study

Finite Element Modeling of the Lamina Cribrosa Microarchitecture in the Normal and Early Glaucoma Monkey Optic Nerve Head

Analytic and Computational Comparison of Poroelastic and Elastic Biomechanical Models for Soft Ocular Tissues

Improved Prediction of Local Trabecular Strain Enhances Non-Invasive Assessment of Micro Bone Strength Using a Surface Smoothing Technique in FEA

A New Versatile Mechanistic Collagen Remodeling Algorithm

Morphological Variations of the Femural Head and Acetabulum: Femoro-Acetabular Impingement and Dysplasia as Possible Initiators of Cartilage Degeneration

Intra- and Extrafibrillar Fluid Exchange in the Disc

A Molecular Modelling Approach for Designing Bioartificial Membranes for Clinical Use With Tailored Transport Properties

Cellular Mechanics and Biology of Tumor Cell-Leukocyte Interactions in the Near Wall Region Under Shear Flow Conditions

Development of a Computational Model to Study Effects of Rotator Cuff Tear Size and Location on Muscle Moment Arms

Contributions of Trabecular Rods of Various Orientations in Determining the Elastic Properties of Human Vertebral Trabecular Bone

Computational Simulation of Anterior-Medial Tibial Tuberosity Transfer: Optimization With Simulated Annealing

Three Dimensional Numerical Analysis of Flow Through the Human Carotid Bifurcation With Varying Degrees of Stenotic Plaque Formation

Diametral Compression of Hollow Non-Circular Bone Sections

Patient-Specific Finite Element Model to Simulate the Behaviour of a Scoliotic Spine

Effect of Head Posture Changes in the Geometry and Hemodynamics of a Healthy Human Carotid Bifurcation

Toward Determining a Dynamic Impedance Boundary Condition

Computationally Efficient, Explicit Finite Element Model for Evaluation of Patellofemoral Mechanics

Towards a Unified Multi-Scaled Theoretical-Experimental Paradigm for Characterizing Vascular Remodeling

Simulations of Bioprosthetic Heart Valve Dynamics Using a Sharp Interface Method

Towards the Prediction and Minimization of Device Failure for Endolvascular Grafts in Abdominal Aortic Aneurysms

Image Based Simulation of Pulmonary Airflow Using Multi-Level Voxel Modeling

Comparison of 2-D Fiber Network Orientation Measurement Methods

Cells on a Bed of Micro-Needles: Modeling of the Scaling of the Response

Comparing the Kinematics of Lumbar Spine: Anatomic Facet Replacement System (AFRS™) vs. Rigid Fixation System

Multiscale Adaptive Finite Element Computations for Soft Tissue Biomechanics

Development and Validation of a Subject-Specific Computational Human Knee Model in a Dynamic Knee Simulator

Biphasic Structure-Based Modeling of Tissue Equivalent Mechanics

Effect of a Degenerated C5-C6 Disc on the Biomechanics of Adjacent Levels: A Poroelastic Finite Element Investigation

Finite Element Modeling and Analysis of Human Pelvis

Comparison Between Single Level and Bi-Level Dynamic Stabilization in Lumbar Spondylolisthesis: A Finite Element Study

Calculation of a Shear Strain Parameter for a Three-Dimensional Fung-Type Exponential Model of the Arterial Wall Under Torsion

Simulation of Fall Loading Using a Probabilistic Shape-Based Finite Element Model of Human Femurs

In Vivo Tissue-Level Thresholds for Spinal Cord Injury

Effects of Removal of Uncinate Process in a Cervical Disc Replacement Model: A Finite Element Based Study

A Finite Element Assessment to Compare the Biomechanical Behaviour of Human, Sheep and Chagma Baboon Functional Spine Units

Incorporating the Effects of Variable Wall Properties in Large-Scale Deformable Models of the Cardiovascular System

Predicting Muscle Forces and Joint Moments Using Single Joint and Multi Joint EMG-Driven Models

Effect of Neutrophils Retention Time in Capillaries on Increase in Their Concentration in a Lattice Capillary Network Model

Viscohyperelastic Material Modeling of Liver Tissue

Effect of Corpectomy and Discectomy Fusion Procedures on the Stability of Multi-Level Cervical Construct With Anterior Rigid Screw-Plate Fixation: A Finite Element Model Study

Development of a Discrete Finite Element Cell Model

Validation of MRI-Based Contact Modeling for Analysis of In Vivo Radiocarpal Mechanics

Dynamic Modeling of Shoulder Girdle Range of Motion Limits

Can Simple Trunk Muscle Models Balance and Stabilize Lumbar Spine During Support of Symmetric and Asymmetric Loads?: An FE Model Study

Modeling the Anisotropic Finite-Deformation Viscoelastic Behavior of Soft Fiber-Reinforced Tissues

Variation in the Hemodynamics of Young Adult Carotid Bifurcations

Geometry Anticipates Hemodynamic Phenotype of Basilar Tip Aneurysms

Fluid Structure Interactions in the Eustachain Tube Under Normal and Pathological Conditions

Cyclic Bending of Coronary Plaques Leads to Much Higher Stress Variations: A Major Factor Contributing to Plaque Rupture Risk

Computational Modeling of Ureteral Peristaltic Transport Using Fluid Structure Interaction

Using 3D FSI RV/LV Models Based on Patient-Specific MRI Data to Predict Outcome of PVI and RV Volume Reduction Surgeries

Simulation of the Microcirculation in Rat Spinotrapezius Muscle Fascia

Dynamic Remeshing for Fluid Structure Interaction: Application to Modelling Aortic Dissection

Progressive Increase in Platelet Activation With Smoke Exposure: Human Subject and In-Vitro Studies

An Experimental and Numerical Investigation Into the Deformation Profiles of Mock Arteries

Does the Difference in Realistic Waveform Before and After Stenting Affect Hemodynamics in Stenosed Coronary Artery?

The Effect of Flow Characteristics on Thrombus Formation Rate and Deposition

Airway Reopening: The Pulsatile Propagation of a Finger of Air Through a Fluid-Occluded Cylindrical Tube

Evaluation of Hemodynamic Efficiency in a New “Y-Graft” Design for the Fontan Operation

PIV Experiments to Measure the Velocity Field Just Downstream of an Oscillating Collapsible Tube

Plaque and Shear Stress Distribution in Human Coronary Bifurcations: a Multi-Slice Computed Tomography Study

Strain Distribution Over Plaques in Human Coronary Arteries Relates to Shear Stress

Evaluation of the Dynamics of a Bileaflet Heart Valve: Physical and Numerical Experiments

Simulation of Blood Perfusion in Tumour Microvasculature

Virtual Assessment of the Performance of an Inhalation Drug Delivery Device

Effect of Parenchymal Tethering on the Steady Propagation of a Liquid Plug in a Flexible Airway Model

Hemodynamics and the Natural History of Cerebral Aneurysms

Hepatic Venous Blood Flow Distribution in the Total Cavopulmonary Connection: Patient-Specific Anatomical Models

Arterial Flows in Carotid Artery Dissection

Fluid Dynamic Events Within the Vitreous Cavity Induced by Saccadic Eye Rotations

A Computational Investigation of Blood Flow in Realistic AAA Stent-Grafts

The Dissipation of Suction Waves in Flexible Tubes

Rapid Growth of Cerebral Aneurysms Before Rupture

CFD Modeling for Patient-Specific Analysis of Cerebrospinal Fluid Flow

Numerical Study of Blood Redistribution in the Circle of Willis of Patients With Carotid Artery Stenosis

Use of Cardiac Phase-Contrast MRI to Examine Hemodynamics and Wall Deformation Within the Aortic Root for Patients With Bicuspid Aortic Valves

Techniques for Virtual Stenting of Intracranial Aneurysms

Use of Computational Fluid Dynamics for the Replication of Clinical Blood Flow and Pressure Measurements and Characterization of Hemodynamics in the Normal Ascending and Thoracic Aorta

Stress Analysis of Carotid Arterial Stenosis With 3-D Fluid-Structure Interaction Simulations

Pediatric Blood Viscoelasticity Measurements

Patient-Specific Fluid Structure Interaction Simulation Applied to Evaluating Hemodynamics Within the Total Cavopulmonary Connection

Time Resolved DPIV Analysis of Pulsatile Flow in Symmetric Stenotic Arteries: A Comparison Between Arterial and Coronary Flow

Flow Alteration Through Nasal Passages Due to Turbinectomy

Development and Response of Materially-Nonlinear, Multi-Layer Synthetic Models of the Human Vocal Folds

A Three Dimensional Simulation of Fluid-Structure Interaction

Fully Coupled vs. Partially Coupled Fluid-Structure Interaction Methods for Patient-Specific Abdominal Aortic Aneurysm Biomechanics

CFD Model of Dynamic Thrombus Growth With and Without Shear Rate Dependant Deposition

Free Surface Coating Flows of Non-Newtonian Gels: 3-D Numerical Simulation of Gravity-Induced Flow

Risk of Rupture in AAA and Vulnerable Plaques: Patient Based FSI Simulation

Damage Accumulation Model, FSI, and Multiscale Simulations for Studying the Thrombogenic Potential of Prosthetic Heart Valves

Accuracy of Cartilage Geometry Reconstruction From Volumetric CT Data: A Phantom Study

Entropy Based Phase Aberration Correction Technique in Ultrasound Imaging

Determination of Real Time In-Vivo Cartilage Contact Deformation in the Ankle Joint

Methods for Quantifying Vessel Deformation Due to Pulsatile and Non-Pulsatile Forces

Validation of an MRI-Based Method for Measuring the Deformation of the Brain During Angular Acceleration

Peak Gluteal Muscle Strain and Stress Values During Sitting Are Greater in Paraplegics Than in Normals

Development of Carbon Nanotube Field Emitters for X-Ray Source

MRI Measurement of Surface Strain Due to Growth in the Developing Ferret Brain

Addition of Particle Tracking Techniques to Improve Two-Dimensional Echo PIV for Opaque Flow Measurement

Image Based CFD Modeling of Coronary Artery Wall Shear Stress and Importance of Patient-Specific Velocity Boundary Conditions

Development of 4-D High-Resolution CT for Measurement of Airway Deformation

Automated Segmentation and Morphometric Measurement of a Human Airway Tree From Multi-Detector CT Images Toward the Numerical Analysis of Pulmonary Flow Dynamics

Non Invasive Measurement of Blood Flow in the Human Lower Extremity

3D Reconstruction of Patient-Specific Abdominal Aortic Aneurysms: From CT Scan to Silicone Model

Simultaneous Measurements of Velocity and Deformation in Flows Through Compliant Orifices Used as Heart Valve Analogues

Computational Investigation on the Dispersive Transport of Angiographic Contrast Injected Antegradely Into Flow in a Tube

Real-Time Measurement of Multi-Component Velocity Vectors Within Abdominal Aortic Aneurysms Using Echo PIV: Comparison of In Vitro and Computational Results

A Skeletalized Representation of the Total Cavopulmonary Connection

Extraction and Selection of Characteristics in Skin Lesions Images Using Wavelets in Multiresolution Analysis

A 3d Histomorphometric Method for Analyses of Skeletal Tissue Mechanobiology

Dynamic Imaging of the Lumbar Spine

Experimental Investigation on the Dispersive Transport of Angiographic Contrast Injected Antegradely Into Flow in a Tube

Assessment of a Novel Technique for In-Vivo Investigation of Joint Cartilage Deformation Characteristics

Quantitative Imaging of Nanoparticles and Intracellular Vesicle Trafficking Using Total Internal Reflection Fluorescent Microscopy (TIRFM)

Live Cell Detection of Specific Messenger RNA for Molecular Analysis of Plaque Formation

The Effectiveness of Adult Safety Belt Systems for Child Occupants: What Is the Role of the Booster Seat?

Dynamic Out-of-Position Deployment of Thoracic Side Airbags

The Influence of Age on the Forces Produced During Normal Seat Belt Buckling

Collagen Fiber Organization in the Cervical Facet Capsular Ligament Following Painful Facet Joint Distraction in the Rat

The Protective Role of Bacillus Anthracis Exosporium in Macrophage-Mediated Killing by Nitric Oxide

Effects of Short Duration Overpressure on Astrocytes: An In Vitro Study

Development of a New Device for In-Vitro Simulation of Upper Extremity Fractures

Determination of Diffuse Brain Injury Thresholds Using Retrospective Analysis

Leukocytes Cause Inflammatory Response to Traumatized Articular Cartilage in Acute Phase of Joint Injury

Experimental Study on Non-Exit Ballistic Induced Traumatic Brain Injury

Ameliorating Glycosaminoglycan (GAG) Loss and Cell Death in Articular Cartilage Following Single-Impact Loading

Dynamic Distraction of the Cervical Facet Joint Produces Higher Mechanical Allodynia than Quasistatic Distraction: Implications of Displacement Thresholds for Pain in Whiplash Loading

Finite Element Modeling of Rollover Crash Tests With Hybrid III Dummies

Biomechanical Quantification of Flexion Movement (Ducking) of the Human Head-Neck and Rollover Accidents

Biomechanical Analysis of Late Airbag Deployment in Motor Vehicle Crashes Using Computer Simulation

The Development of an Injury Corridor to Assess Lower Extremity Injuries Resulting From Anti-Vehicular (AV) Landmine/Improvised Explosive Device (IED) Blasts in Military Vehicles

Inertial Neck Injuries in Children Involved in Frontal Collisions: Sled Testing Using the 6-Year-Old ATD

Mechanical Properties of the Chick Embryo Spinal Cord

A Method to Discriminate Pulmonary Contusion Severity Through Analysis of Hounsfield Unit Frequency

Tibial Tuberosity Realignment Decreases Pressure Applied to Patellofemoral Cartilage

Gender Specific Material Properties in the Thoracic Spine

A Novel In Vivo Measurement of Three-Dimensional Lumbar Facet Joint Orientation and Area

Feasibility of Measuring the Effect of Knee Injury Prevention Training on Dynamic ACL Length During Jump Landing

Cartilage Damage in the Unstable Knee is Related to Tibio-Femoral Contact Mechanics

Characterization of the In Vivo Forces on the Sternum in Pigs

Does Lift-Off Occur During Deep Squat?

Validation of a High-Payload Robotic/UFS Testing System for Studying of Joint Motion

A Novel Measure of In-Vivo Knee Joint Laxity

Optimization of Quadriceps Force Distribution for Minimization of Patellofemoral Contact Pressure During a Squat

3D Finite Strains in Bovine Annulus Fibrosus Tissue

Validation of a Computational Musculoskeletal Model of the Elbow

Measuring Moment Arms Using Closed-Loop Force Control With an Elbow Simulator

A Rat Model of Osteoarthritic Temporomandibular Joint Pain: Mechanically-Induced Behavioral Hypersensitivity and Histologic Modifications

Moment Arms of the Intrinsic Muscles at the PIP Joint of the Middle Finger are Independent of the Position of the MCP Joint

Durability Test Method for Patella Implants

Knee Joint Motion Quantified Using the Finite Helical Axis Method

Deep Knee Activities: In Vitro Kinematic Measurements to Compare With In Vivo Studies

In-Vivo Tibiofemoral Contact Stress in the Knee After TKA

Knee Kinematics During an In Vitro Simulated Deep Flexion Squat

Comparison of Three Repair Techniques to Restore Scapholunate Kinematics in a Cadaver Model of a Simulated Scapholunate Dissociation

Accuracy and Repeatability of Electronic and Static-Film Pressure Sensors Under Controlled Test Conditions

Using Force and Kinematic Driven Finite Element Models to Analyze Contact Pressure Distributions on the Tibial Plateau

Facet Joint Capsule Strains as a Result of Normal and Degenerate Intervertebral Discs

Augmentation With Cortoss Improves Vertebral Body Compression Biomechanics for Lumbar Total Disc Replacement

Frequency Dependence of Viscoelastic Materials for Small Joint Replacements

Kinetic and Biomechanical Testing of Two-Level Cervical Disc Replacement

A Fluid Dynamics Study Focusing on Wall Shear Rates Within the Penn State 12 cc Pulsatile Pediatric Ventricular Assist Device: A Comparison of Mechanical Heart Valve Types

Experimental In-Vitro Method to Measure the Migration of Cementless Prosthesis

Advanced Material Modeling of UHMWPE for Orthopaedic Implant Design

Thrombotic Potential of a Prosthetic Vein Valve

Fluid Mechanical Analysis at Closure of the On-X Mechanical Heart Valve

Grasping Contact Analysis of Tissues With Semi-Cylindrical Teeth Grasper for Minimally Invasive Surgery Applications

Transitional Stiffness Intramedullary Stems to Reduce Periprosthetic Pain

Finite Element Method to Evaluate Effects of Hip Implant Geometry on Bone Cement Stress Distribution

The Effect of Red Cell Dynamics on Platelet Spatial Distribution in Sudden Expansion

CFD Modeling of Transient Flow Phenomena in an Axial Flow VAD

MR Safety and In Vivo Thermal Characterization of an RF Coil at 9.4T

Stented Artery Biomechanics in the Presence of Stenoses and Tapering

Diastolic Dysfunction Persists After Unloading by Left Ventricular Assist Device (LVAD) Support

Identification of a Mathematical Model for the Prediction of Platelet Damage Accumulation in Artificial Organs: A Preliminary Study

Impact of the Balloon Folding Pattern on the Transient Stent Expansion Behaviour: A Finite Element Study

Next Generation Knee Replacements: A New Approach to Replicate the Function of the ACL

Effectiveness of Trabecular Metal™ Acetabular Augment in Revision THR of Pelvis With Severe Acetabular Defect: A Finite Element Study

Screw/Plate Stability in Universal Locking Plate: A Novel Internal Fixator

Quantification of Three-Dimensional Motion of the Renal Arteries Using Image-Based Modeling Techniques

Measurement of Endovascular Stent Mechanical Properties

Finite Element Stent Design: Parametric Modeling of Braided Wirestents Using PyFormex

Magnetic Vascular Positioner for Automatic Coronary Artery Bypass Grafting Does Not Significantly Increase the Risk of Failure Related to Local Fluid Dynamics: A Numeric Study

Left Ventricular Assist Device Evaluation With a Model-Controlled Mock Circulation

Numerical Simulation of Blood Flow Through Mechanical Heart Valves Using Meshless Techniques

MRI Evaluation of a Stented Abdominal Aorta of a Rabbit

Changes in Material Properties of Dialysis Membranes Due to the Effect of High Flux Dialysis

Compensatory Motion During a Bilateral Lifting Task for Transradial Prosthetic Design

Constitutive Model of Biodegradable Non-Linear Polymeric Materials for Applications in the Biomedical Field

A Scaled-Up Mechanical Prosthetic Heart Valve Model for High-Resolution Flow Field Measurements

Effect of Stent Design Parameters on Fluid and Structural Mechanics in Coronary Arteries

The Effect of Embolic Protection Filters on Distal Embolization and Slow Flow Condition in Carotid Artery Stenting

Effects of Discontinuous Fiber Reinforcement on the Mechanical and Thermomechanical Properties of a Shape Memory Polymer

Noninvasive Blood Perfusion Measurement on the Liver of an Anesthetized Rat

An Implantable Transit-Time Aortic Flow Probe Using Capacitive Micromachined Ultrasound Transducers: Design and Optimization

Using Triple-Density Bone Analog to Evaluate the Initial Fixation of a Cementless Tibial Implant

Mechanical Loading of Suspended Cells in Laminar and Turbulent Blood Flow

Development of Experimental and Computational Models to Evaluate the Stability of Aortic Stent Grafts in Motor Vehicle Accidents

Design and Fabrication of a Mock Circulatory System for Reliability Tests on Aortic Heart Valves

Thermal Treatment Effects on a PLLA Bioresorbable Stent

High Intensity Focused Ultrasound (HIFU) Transducer Characterization Using Acoustic Streaming

An Implantable Magnetoelastic Sensor System for Wireless Physiological Sensing of Viscosity

A Genetic-Algorithm-Based Design Approach to Minimize Abnormal Hemodynamics Parameters at the End-to-Side Distal Anastomoses of Synthetic Bypass Grafts

In Vitro Study of Flow Regulation for Pulmonary Insufficiency Using Diode Valves

Valleylab Hand-Switching LigaSure™ XTD (Patent Pending) Design Project

Stent Induced Smooth Muscle Cell Proliferation: An In Vitro System for Rapid Evaluation

Developing an Active Ankle Foot Orthosis Based on Shape Memory Alloy Actuators

Experimental and Numerical Modelling of the Ventriculo-Sinus Shunt to Treat Malresoptive Hydrocephalus

Evaluation of the Effect of Stent Strut Profile on Shear Stress Distribution

Sequence Specific Role of Water in Spontaneous Local Unwinding of Collagen

Mechanism of Force Generation in Kinesin Motility

Supramolecular Structure and Stability of the GNNQQNY β-Sheet Bilayer Filament: A Computational Study

What Molecular Dynamics Simulations Can Tell Us About Mechanical Properties of Kinesin and Its Interaction With Tubulin

Superelasticity of Vimentin Coiled-Coil Intermediate Filaments: Atomistic and Continuum Studies

Deformation-Dependent Enzyme Cleavage of Collagen

Molecular Dynamics Simulations of Dialkyl Carbocyanine Dyes in a DPPC Bilayer: Atomistic Insights Into Single Molecule Fluorescence

Alternative Splicing for Mechanical Resilience: The Softening Effect of Filamin’s Hinge

Anatomically Correct Right Coronary Artery Model

Mechanical Conditioning Stimulates the Development of Tissue Properties in Engineered Cardiovascular Constructs

Ischemic Factors and Deformation Influence Metabolism of Engineered Skeletal Muscle

Mesenchymal Progenitor Cells Differentially Respond to Mechanical Stimulation: Morphology, Proliferation, Gene and Protein Expression

The Role of IL-1 in Meniscal Tissue Breakdown Following Simulated Partial Meniscectomy

Effects of Local Mechanical Stimulation on Cellular Behavior

Cytokine and Chemokine Release Upon Sustained Mechanical Loading of the Epidermis

Anisotropic Strain Effects on Vascular Smooth Muscle Cell Physiology

Strain Induced Bladder Smooth Muscle Remodeling

Respose of Cultured Nasal Epithelial Cells to Wall Shear Stress

Effects of Steady Spatial Wall Shear Stress Gradients on Endothelial Cell Morphology in Three-Dimensional Models

Gelatinase B (MMP-9) Modulates Joint Inflammation and Cartilage Degradation After Overload Injury

A Novel Experimental Technique for Quantifying the Local Mechanical Environment of Skeletal Tissues

Hyaline Characteristics of Mechanically Induced Cartilaginous Tissues

Load Down-Regulates TNF-Alpha Induced Cartilage Degradation in Part Through NF-KB and P38 Pathways

A Novel Method for Frictional Testing on Adherent Cells

Development of a System for Application of Dynamic Mechanical Compression on Intervertebral Discs in Organ Culture and Investigation of Load Magnitude Effects

Effect of Age and Frequency on Intervertebral Disc Cell Response to Dynamic Compression

Multiscale Stress Analysis of Sheared and Focally-Adhered Endothelial Cells: Role of Subcellular Matrix Moduli in Focal Adhesion-Mediated Signaling

Effect of Stretch on Bladder Smooth Muscle Cells in Three-Dimensional Culture

A Proposed New Brain Injury Tolerance Criterion Based on the Exchange of Energy Between the Skull and the Brain

Mechanical Stimuli Resulting From Embryonic Muscle Contractions Promote Avian Periosteal Bone Collar Formation

Characterizing the Influence of Preconditioning on Initial Tension for Hamstring Tendon and Patella Tendon Grafts

Mechanical Properties of Polyurethane Foam Compared With Values for Normal and Osteoporotic Human Cancellous Bone

Mechanical Loading Uniquely Up-Regulates MMP-13 in Rat Supraspinatus Tendon But Not Achilles Tendon

Fracture Resistance of Human Amnion

Systematic Error in the Measure of Microdamage by Modulus Degradation During Four-Point Bending Fatigue

Specimen Specific Multiscale Model for the Anisotropic Elastic Properties of Human Cortical Bone Tissue

Extended Two Compartmental Swelling Stress Model and Isotropic Cauchy Stress Equation for Articular Cartilage Proteoglycans

Differential Expression of Fibulin Family Proteins in Mechanically Strong vs. Weak Fetal Membrane Fragments

A Mechanical and Computational Investigation on the Effects of Conduit Orientation on the Strength of Massive Bone Allografts

Shoulder Tendon Repair Biomechanics Using a Polyurethane Patch in a Chronic Ovine Defect Model

Magnetic Resonance Elastography of the Mouse Brain In Vivo

Mode Changes in the Post-Yield Behavior of Bone

Reduction of the Wnt Inhibitor Dkk1 Correlates With Improved Bone Mechanical and Morphological Properties in Mice

A Cartilage Growth Mixture Model With Collagen Remodeling: Validation Protocols

Deformation of the Human Brain Induced by Mild Angular Acceleration

Micromotions at the Bone Implant Interface Up-Regulate Osteoblasts-Mediated Activation of Osteoclasts in Ex Vivo Human Samples

Measurement of Acoustic Emission Wave Attenuation by Bones and Muscles

Prediction of Mechanical Properties of Vertebral Trabecular Bone Using Microstructural Finite Element Models

Effect of Defect on Elastic/Plastic and Creep Behavior of Bone: A Finite Element Study

Constitutive Modeling of Skeletal Muscle Tissue

The Roles of Elastic Fibres and Glycosaminoglycans in the Radial Tensile Mechanics of the Human Lumbar Anulus Fibrosus

Investigation of Cartilage Biomechanical Properties: Dependence on Strain, Direction, and Biochemical Composition

Accelerated Bone Growth Remotely Induced by Magnetic Fields and Smart Materials

Increased Bone Mechanical Properties of Mice Lacking βArrestin2 After Mechanical Stimulations

A Study of Collagen Crimp Pattern in the Bovine Anterior and Posterior Medial Meniscal Horn Attachments

Iris Stiffening Following Drug Stimulation

Remodeling of Fracture Callus in Mice Can Be Explained by Mechanical Loading

Viscoelastic Properties of Injured and Uninjured Rat Brain Tissue

Interactions Between Factors Influencing Optic Nerve Head Biomechanics

Tissue Strain Transduction and Amplification at the Osteocyte as a Result of Microstructural Changes in the Bone Matrix

The Mechanical and Viscoelastic Properties of the Healing Rabbit Patellar Tendon

Microindentation Testing of Rat Brain Tissue Slices

A Semi-Empirical Constitutive Model for Post Yield Behavior of Bone in Tension

The Effect of Nonlinear Scleral Properties on Optic Nerve Head Biomechanics

Effects of Tissue Swelling on Macromolecular Transport in Nervous Tissue: A Simulation Analysis

Influence of Early Ovariohysterectomy on the Mechanical Properties of Rabbit Medial Collateral Ligament

Nonlinear Finite Element Modeling of Monkey Posterior Sclera Under Intraocular Pressure

Characterizing Strain in the Tibia of Rats Exposed to Hindlimb Unloading With an Exercise Countermeasure

Effects of Gender on the Mechanical Properties of the Glenohumeral Capsule: Implications for Surgical Repair Techniques

Rotational Acceleration Duration Affects Brain Strains in Lateral Impact

Mechanical Behaviour of the Subcutaneous Fat Layer

Longitudinal Measurement of In-Vivo Tendon Function Over 17 Weeks Following Repair: Technique and Preliminary Results in a Canine Rotator Cuff Model

Mineral Composition at the Tendon-to-Bone Insertion and Its Role in Stress Transfer

Differences Between Principal Strain Directions and Muscle Fiber Directions in the Contracting Biceps Bracii Measured With CPC-MRI

Development of a Two-Color Fluorescent Tracer Technique to Study Aqueous Outflow Patterns and Outflow Resistance in Human Eyes

Micro CT-Based Large Scale Finite Element Modeling of Compressive and Torsional Properties of Human Cortical Bone

Multiphasic Mechano-Electrochemical Finite Element Model of Human Intervertebral Disc

The Effects of Pressure and Shear on Capillary Closure in the Microstructure of Skeletal Muscles: Computational Studies

Quantifying Variations in Collagen Matrix Deformation in Loaded Articular Cartilage

Measuring the Biaxial Stress-Strain Characteristics of Human Sclera

Biaxial Mechanics of Musculoskeletal Tissue and Fiber-Reinforced Scaffolds

The Anisotropy and Tension/Compression Behavior of Human Cervical Tissue

Consequences of Long-Term Cyclic Indentation on Initially Intact Cartilage

An in Situ Dual Indentation and Optimization Method to Determine Mechanical Properties of Articular Cartilage

Bone Formation and Inhibition of Bone Loss by Dynamic Muscle Stimulation With Altered Interstitial Fluid Pressure

Elasticity of Cartilage Measured by Large Strain, Non-Hertzian AFM Nanoindentation

Frictional Characteristics and Tissue Loss of Articular Cartilage Under a Novel Wear Regime

Depth Dependent Strain Analysis of Articular Cartilage Under Impaction Loading

Viscoelastic Characterization of Perfused Liver: Indentation Testing and Preliminary Modeling

Preservation of Human Bone Remains at Joya De Cerèn

Continuum-Level Finite Element Modeling of the Optic Nerve Head Using a Fabric Tensor Based Description of the Lamina Cribrosa

Tissue Swelling During Extended Material Testing of Ligaments

A Compressible, Transversely Isotropic, Hyperelastic Constitutive Model of the Guinea Pig Spinal Cord White Matter

Structure Mechanical Function Relationships of the Fetal Membrane

Poroviscoelastic Properties of Mouse Cartilage From Inverse Finite Elements and Indentation

Micro-CT-Based Large Scale Linear Finite Element Models Predict the Strength of Human Thoracic and Lumbar Vertebral Bodies

A Practical Method for Real-Time Optical Imaging of Damage Zone and Microscale Failure in Bone

Voluntary Running Exercise Ameliorates Muscle Loss in Mice

Mechanical Property Determination of Bone Through Nanoindentation Testing and Finite Element Simulation

Unconfined Compression of Porcine Ocular Lenses: Experiments and Finite Element Analysis

Nonlinear Elastic Behavior of Achilles Tendon at the Fascicle Scale

Modulating Human Connective Tissue Progenitor (CTP) Cell Behavior on Cellulose Acetate Scaffolds by Surface Microtextures

Mechanical and Biochemical Comparison of Cell-Derived Matrix, Collagen Gels, and Fibrin Gels for Tissue Engineering Applications

Mechanical Stimulation Increases Collagen Type I and Collagen Type III Gene Expression of Stem Cell: Collagen Sponge Constructs for Patellar Tendon Repair

Effect of Mechanical Stimulation on the Biomechanics of Stem Cell: Collagen Sponge Constructs for Patellar Tendon Repair

Decorin Deficient Cells Demonstrate Increased Proliferation and Altered Phenotypic Properties

3D Coculture of Human Endothelial Cells and Myofibroblasts for Vascular Tissue Engineering

A Finite Element Prediction of Cellular Strain in a GAG-Scaffold

Neurite Elongation and Branching on DNA Crosslinked Polyacrylamide Hydrogels

Engineered MSC-Laden Cartilage Constructs are Sensitive to Inflammatory Cytokine-Mediated Degradation

Elevated Basement Membrane Fibroblast Growth Factor-2 Protects Endothelial Cells in High Glucose

Electrospinning of Photopolymerizable Poly(β-Amino Ester) Networks for Fibrous Tissue Engineering

Influence of Interleukin Treatment on Engineered and Native Articular Cartilage

Novel Nanostructured Calcium Phosphate Based Delivery Systems for Non-Viral Gene Delivery

Substrate Stiffness Affects Laminin-332 Matrix Deposition in Cultured Keretinocytes

Evaluation of a Novel Scaffold Material for Tendon Tissue Engineering

Combined Effect of Glycosaminoglycan and Mechanical Stimulation on the In Vitro Biomechanics of Tissue Engineered Tendon Constructs

Pulsatile Pressure System for Cellular Mechanical Stimulation

Sliding Contact Modulates ECM Expression in Chondroctye-Laden Agarose Gels

Multi-Lamellar and Multi-Axial Maturation of Cell-Seeded Fiber-Reinforced Tissue Engineered Constructs

Defined Medium for the Self-Assembling Process: Enhancing Functionality of Tissue Engineered Articular Cartilage

Enhanced Cellular Infiltration With Removal of Sacrificial Fibers From a Dual-Polymer Nanofibrous Scaffold

Effects of Hydrostatic Pressure on Meniscus Cell-Seeded PLLA Scaffolds

Fabrication and Properties of Collagen Fibers With Increased Surface Areas for Enhanced Fiber-Matrix Interactions

The Response of Tissue Engineered Cartilage to the Temporal Application of Transforming and Insulin-Like Growth Factors

Autologous Human Fibrochondrocytes From Meniscectomy Debris are a Potent Cell Source for Meniscus Tissue Engineering

Rheological Properties of Extracellular Matrix Derived Gels

Dynamic Hydrostatic Pressurization Differentially Regulates Extracellular Matrix Elaboration by Bovine Inner and Outer Annulus Fibrosus Cells Seeded on 3-D Polymer Scaffolds

Scaffold Properties Play a Critical Role in the Retention of Synthesized Glycosaminoglycans in Tissue Engineered Cartilage

Microvascular Oreintation During Angiogenesis: Effects of Mechanical Stretch and Boundary Conditions

The Effects of Culture Conditions and Implantation on the Structural and Mechanical Characteristics of a Tissue Engineered Urethral Wrap

3D Cell Shape and Cell Fate are Regulated by the Dynamic Micro-Mechanical Properties of the Cell-ECM Interface

Characterization of Carbon Nanotube-Conjugated Collagen Composite Matrix Mechanics

Chondrocytes and Fibrochondrocytes Differentially Process Aggrecan During De Novo Extracellular Matrix Assembly

Improving the Anisotropy of Collagen by Electric Field Increases Its Toughness by Two-Fold

Local Non-Affine Deformations and Fiber Kinematics of Elastomeric Electrospun Scaffolds

Cellular Deformations in Microintegrated Electrospun Poly (Ester Urethane) Urea Scaffolds Under Biaxial Stretch

Effects of Interface Conditions and Volume Fraction on the Apparent Stiffness of Surrogate Multicellular Constructs

Freezing Induced Microstructural Change of Collagen Matrix

Characterization of Cell Association and Heat Treatment Using Iron Oxide Magnetic Nanoparticles

Influence of Nutrient Channels on Development of Engineered Cartilage Properties

Pressure Induced Strain at Femoral Artery Bypass Graft Junctions

Effects of Anomalous Diffusion Mechanisms in Developing Tissue Engineered Constructs

Fickian Behavior and Concentration-Dependence of the Diffusion of Dextran in Agarose

ASME 2008 Summer Bioengineering Conference(SBC2008)

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Turbo Expo: Power for Land, Sea, and Air

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Water Quality, Drought, Human Health and Engineering Conference

Wind Energy Symposium

World Conference on Innovative Virtual Reality

World Tribology Congress

Effects of Steady Spatial Wall Shear Stress Gradients on Endothelial Cell Morphology in Three-Dimensional Models

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Rouleau, Leonie Farcas, Monica Tardif, Jean-Claude Mongrain, Rosaire Leask, Richard
Copyright Year	2007
Abstract	Endothelial cell (EC) dysfunction has been linked to atherosclerosis through their response to hemodynamic forces. Flow in stenotic vessels creates complex spatial gradients in wall shear stress. In vitro studies examining the effect of shear stress on endothelial cells have used unrealistic and simplified models, which cannot reproduce physiological conditions. The objective of this study was to expose endothelial cells to the complex shear shear pattern created by an asymmetric stenosis. Endothelial cells were grown and exposed for different times to physiological steady flow in straight dynamic controls and in idealized asymmetric stenosis models. Cells subjected to 1D flow aligned with flow direction and had a spindle-like shape when compared to static controls. Endothelial cell morphology was noticeable different in the regions with a spatial gradient in wall shear stress, being more randomly oriented and of cobblestone shape. This occurred despite the presence of an increased magnitude in shear stress. No other study to date has described this morphology in the presence of a positive wall shear stress gradient or gradient of significant shear magnitude. This technique provides a more realistic model to study endothelial cell response to spatial and temporal shear stress gradients that are present in vivo and is an important advancement towards a better understanding of the mechanisms involved in coronary artery disease.
Sponsorship	Bioengineering Division
Starting Page	811
Ending Page	812
Page Count	2
File Format	PDF
ISBN	0791847985
DOI	10.1115/SBC2007-176441
Conference Proceedings	ASME 2007 Summer Bioengineering Conference
Language	English
Publisher Date	2007-06-20
Publisher Place	Keystone, Colorado, USA
Access Restriction	Subscribed
Subject Keyword	Three-dimensional models Vessels Atherosclerosis Shear stress Physiology Shapes Hemodynamics Shear (mechanics) Flow (dynamics) Endothelial cells Coronary arteries Diseases
Content Type	Text
Resource Type	Article

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