NDLI: Towards a Failure Criterion for Microtubules Based on Matching Strength Analysis in Finite Element Models to AFM Loads

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Taylor, William Shepard, W. Steve Candace, L. Floyd
Copyright Year	2011
Abstract	In previous research studies, the geometric and elastic properties for a critical component of axon health, the microtubule (MT), have been determined using lateral indentation with the tip of an atomic force microscope (AFM). Although the response due to the indentations caused by the AFM was observed to be linear for most of the tests, forces greater than 300pN would result in a permanent irreversible collapse of the MT’s structure. While the intent of those researchers was not to evaluate microtubule strength properties, that load can be used as a starting point to evaluate internal stress failure criterion for such structures. To that end, the current research is investigating MT strength by replicating the loading and boundary conditions in a finite element model. This work is an extension of previous work aimed at using this 300 pN point load to develop failure criteria for MTs under more realistic loading conditions. In the present work, modeling has been used to correlate the AFM point load response with the more realistic distributed loading conditions that would result during a brain injury event. Furthermore, the impact of nearby MTs on the stresses that occur under similar loading conditions is also examined. These results are being used to analytically determine a stress threshold related to MT structural failure. Correspondingly, models that include dynamic wave propagation through the microtubule will be studied. The failure criterion determined in both cases would aid in evaluating brain injury studies that involve pressure wave propagation in whole-head finite element models, even when such models represent the white matter using homogeneous properties.
Starting Page	901
Ending Page	913
Page Count	13
File Format	PDF
ISBN	9780791854884
DOI	10.1115/IMECE2011-63859
Volume Number	Volume 2: Biomedical and Biotechnology Engineering; Nanoengineering for Medicine and Biology
Conference Proceedings	ASME 2011 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2011-11-11
Publisher Place	Denver, Colorado, USA
Access Restriction	Subscribed
Subject Keyword	Collapse Atomic force microscopy Finite element model Traumatic brain injury Wave propagation Structural failures Elasticity Boundary-value problems Modeling Pressure Failure Stress
Content Type	Text
Resource Type	Article

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