NDLI: Characterization of Irregular Stress Distributions Induced by Klippel Feil Syndrome

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Leung, Enoch Sarigul-Klijn, Nesrin Rolando, F. Roberto
Copyright Year	2011
Abstract	Klippel Feil Syndrome (KFS) is a congenital disorder characterized by failure of segmentation of cervical vertebrae, resulting in “fusions” at any level of the cervical spine. Clinical diagnosis of KFS occurs at a mean age of 7.1 years, with children diagnosed with KFS often exhibiting reduced motion and function characterized by reduction of upward and downward motions of the head on the neck (flexion/extension), axial rotation, and tilting of the head side to side (lateral bending). More importantly, however, previous KFS studies have acknowledged possible compromises to the structural integrity and overall health of the cervical spine in the presence of abnormal fusion. Instances of instabilities such as fracture and large amounts of mobility at vertebral segments adjacent to fusion have been recorded, both posing significant neurological and physiological dangers to an individual afflicted with KFS. While fusion and instability appear to be interrelated, more intrinsic evaluation of KFS-related instabilities is needed. Current KFS studies, relying predominantly on static radiographic modalities, have been unsuccessful in identifying factors contributing to craniocervical (CC) destabilization in the presence of congenital vertebral fusion. It has been hypothesized that fusion of vertebral bodies induces abnormal stress distributions that catalyze instances of fracture along any KFS spine segment. Using Finite Element (FE) Modeling and Analysis to characterize motion alterations and irregular stress patterns associated with vertebral fusion, a high fidelity computational representation of a KFS affected cervical spine segment spanning the base of the occiput to C6 was constructed. Computer Tomography (CT) images were used for vertebral reconstruction with soft tissue components such as intervertebral discs (IVDs), articular cartilages (ACs), and the transverse ligament were modeled as homogenous solid components.
Starting Page	183
Ending Page	189
Page Count	7
File Format	PDF
ISBN	9780791854884
DOI	10.1115/IMECE2011-63343
Volume Number	Volume 2: Biomedical and Biotechnology Engineering; Nanoengineering for Medicine and Biology
Conference Proceedings	ASME 2011 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2011-11-11
Publisher Place	Denver, Colorado, USA
Access Restriction	Subscribed
Subject Keyword	Computers Mechanical admittance Nervous system Fracture (materials) Intervertebral discs Modeling Rotation Stress Soft tissues Fracture (process) Cartilage Image segmentation Physiology Finite element analysis Cervical spine Failure
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in