NDLI: Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production.

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Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production.

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Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sidney, John Kolla, Ravi Broide, David H. Peters, Bjoern Pomés, Anna Tripple, Victoria Greenbaum, Jason Sette, Alessandro Grey, Howard Oseroff, Carla Wood, Robert
Description	Country affiliation: United States Author Affiliation: Oseroff C ( La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.)
Abstract	Bla g allergens are major targets of IgE responses associated with cockroach allergies. However, little is known about corresponding T cell responses, despite their potential involvement in immunopathology and the clinical efficacy of specific immunotherapy. Bioinformatic predictions of the capacity of Bla g 1, 2, 4, 5, 6, and 7 peptides to bind HLA-DR, -DP, and -DQ molecules, and PBMC responses from 30 allergic donors, identified 25 T cell epitopes. Five immunodominant epitopes accounted for more than half of the response. Bla g 5, the most dominant allergen, accounted for 65% of the response, and Bla g 6 accounted for 20%. Bla g 5 induced both IL-5 and IFN-Î³ responses, whereas Bla g 6 induced mostly IL-5, and, conversely, Bla g 2 induced only IFN-Î³. Thus, responses to allergens within a source are independently regulated, suggesting a critical role for the allergen itself, and not extraneous stimulation from other allergens or copresented immunomodulators. In comparing Ab with T cell responses for several donor/allergen combinations, we detected IgE titers in the absence of detectable T cell responses, suggesting that unlinked T cell-B cell help might support development of IgE responses. Finally, specific immunotherapy resulted in IL-5 down modulation, which was not associated with development of IFN-Î³ or IL-10 responses to any of the Bla g-derived peptides. In summary, the characteristics of T cell responses to Bla g allergens appear uncorrelated with IgE responses. Monitoring these responses may therefore yield important information relevant to understanding cockroach allergies and their treatment.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1200694
Journal	The Journal of Immunology
Issue Number	2
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-07-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Allergens Immunology Aspartic Acid Endopeptidases Epitopes, T-lymphocyte Immunoglobulin E Biosynthesis Insect Proteins T-lymphocyte Subsets Tropomyosin Metabolism Amino Acid Sequence Animals Cells, Cultured Hla-dp Antigens Hla-dq Antigens Hla-dr Antigens Molecular Sequence Data Protein Binding Pathology Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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