NDLI: In vivo VL-targeted microbial superantigen induced global shifts in the B cell repertoire.

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Identification of protective B cell antigens of Legionella pneumophila.

In vivo VL-targeted microbial superantigen induced global shifts in the B cell repertoire.

Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.

Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection.

Structural characterization and inhibitory profile of formyl peptide receptor 2 selective peptides descending from a PIP2-binding domain of gelsolin.

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Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production.

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Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages.

Phenotypic and functional characterization of NK cells in human immune response against the dimorphic fungus Paracoccidioides brasiliensis.

Exosomes isolated from mycobacteria-infected mice or cultured macrophages can recruit and activate immune cells in vitro and in vivo.

IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms.

Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis.

Increased frequency of suppressive regulatory T cells and T cell-mediated antigen loss results in murine melanoma recurrence.

IFN-Î³-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

Innate instruction of CD4+ T cell immunity in respiratory bacterial infection.

B cell tolerance and positive selection in $lupus^{}$

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In vivo VL-targeted microbial superantigen induced global shifts in the B cell repertoire.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Grönwall, Caroline Kosakovsky Pond, Sergei L. Young, Jason A. Silverman, Gregg J.
Description	Country affiliation: United States Author Affiliation: Grönwall C ( Department of Medicine, New York University School of Medicine, New York, NY, USA.)
Abstract	To subvert host defenses, some microbial pathogens produce proteins that interact with conserved motifs in V regions of B cell Ag receptor shared by large sets of lymphocytes, which define the properties of a superantigen. Because the clonal composition of the lymphocyte pool is a major determinant of immune responsiveness, this study was undertaken to examine the in vivo effect on the host immune system of exposure to a B cell superantigen, protein L (PpL), a product of the common commensal bacterial species, Finegoldia magna, which is one of the most common pathogenic species among Gram-positive anaerobic cocci. Libraries of Vκ L chain transcripts were generated from the spleens of control and PpL-exposed mice, and the expressed Vκ rearrangements were characterized by high-throughput sequencing. A total of 120,855 sequencing reads could be assigned to a germline Vκ gene, with all 20 known Vκ subgroups represented. In control mice, we found a recurrent and consistent hierarchy of Vκ gene usage, as well as patterns of preferential Vκ-Jκ pairing. PpL exposure induced significant targeted global shifts in repertoire with reduction of Vκ that contain the superantigen binding motif in all exposed mice. We found significant targeted reductions in the expression of clonotypes encoded by 14 specific Vκ genes with the predicted PpL binding motif. These rigorous surveys document the capacity of a microbial protein to modulate the composition of the expressed lymphocyte repertoire, which also has broad potential implications for host-microbiome and host-pathogen relationships.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1200245
Journal	The Journal of Immunology
Issue Number	2
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-07-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Bacterial Immunology B-lymphocyte Subsets Microbiology Gene Rearrangement, B-lymphocyte Immunoglobulin Variable Region Metabolism Immunoglobulin Kappa-chains Superantigens Animals Biosynthesis Bacterial Proteins Dna-binding Proteins Genetics Mice Mice, Inbred C57bl Peptostreptococcus Pathogenicity Virulence Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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