NDLI: Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 189 Issue: 12

Year: 2012 Volume: 189 Issue: 11

Year: 2012 Volume: 189 Issue: 10

Year: 2012 Volume: 189 Issue: 9

Year: 2012 Volume: 189 Issue: 8

Year: 2012 Volume: 189 Issue: 7

Year: 2012 Volume: 189 Issue: 6

Year: 2012 Volume: 189 Issue: 5

Year: 2012 Volume: 189 Issue: 4

Year: 2012 Volume: 189 Issue: 3

Year: 2012 Volume: 189 Issue: 2

The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells.

Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells.

Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages.

IFN-Î³ elicits macrophage autophagy via the p38 MAPK signaling pathway.

Recruitment of memory B cells to lymph nodes remote from the site of immunization requires an inflammatory stimulus.

Polar opposites: Erk direction of CD4 T cell subsets.

Activation of invariant NKT cells in early phase of experimental autoimmune encephalomyelitis results in differentiation of Ly6Chi inflammatory monocyte to M2 macrophages and improved outcome.

Leishmania donovani exploits host deubiquitinating enzyme A20, a negative regulator of TLR signaling, to subvert host immune response.

Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.

Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation.

A role for the NF-κB pathway in cell protection from complement-dependent cytotoxicity.

Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.

Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumonia.

Breakdown in repression of IFN-Î³ mRNA leads to accumulation of self-reactive effector CD8+ T cells.

HIV-1 infection of human intestinal lamina propria CD4+ T cells in vitro is enhanced by exposure to commensal Escherichia coli.

Human antitumor CD8+ T cells producing Th1 polycytokines show superior antigen sensitivity and tumor recognition.

Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma.

EWI-2 association with -actinin regulates T cell immune synapses and HIV viral infection.

Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease.

Identification, cloning, and functional characterization of the IL-1 receptor antagonist in the chicken reveal important differences between the chicken and mammals.

Retinoic acid attenuates rheumatoid inflammation in mice.

Expression, regulation, and function of atypical chemerin receptor CCRL2 on endothelial cells.

Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.

Identification of protective B cell antigens of Legionella pneumophila.

In vivo VL-targeted microbial superantigen induced global shifts in the B cell repertoire.

Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.

Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection.

Structural characterization and inhibitory profile of formyl peptide receptor 2 selective peptides descending from a PIP2-binding domain of gelsolin.

Gemfibrozil, a lipid-lowering drug, upregulates IL-1 receptor antagonist in mouse cortical neurons: implications for neuronal self-defense.

Platelets present antigen in the context of MHC class I.

Differential idiotype utilization for the in vivo type 14 capsular polysaccharide-specific immunoglobulin responses to intact Streptococcus pneumoniae versus a pneumococcal conjugate vaccine

TGF-ß mediates proinflammatory seminal fluid signaling in human cervical epithelial cells.

Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model.

Molecular mechanisms responsible for the selective and low-grade induction of proinflammatory mediators in murine macrophages by lipopolysaccharide.

The efficiency of human cytomegalovirus pp65(495-503) CD8+ T cell epitope generation is determined by the balanced activities of cytosolic and endoplasmic reticulum-resident peptidases.

Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production.

Defective macrophage migration in G i2- but not G i3-deficient mice.

CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl.

Cutting edge: mast cells critically augment myeloid-derived suppressor cell activity.

Tim-3 pathway controls regulatory and effector T cell balance during hepatitis C virus infection.

Autocrine IFN-Î³ promotes naive CD8 T cell differentiation and synergizes with IFN- to stimulate strong function.

Transient low-dose methotrexate induces tolerance to murine anti-thymocyte globulin and together they promote long-term allograft survival.

NK1.1+ cells and IL-22 regulate vaccine-induced protective immunity against challenge with Mycobacterium tuberculosis.

TNFR-associated factor 2 deficiency in B lymphocytes predisposes to chronic lymphocytic leukemia/small lymphocytic lymphoma in mice.

A computational model for early events in B cell antigen receptor signaling: analysis of the roles of Lyn and Fyn.

Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor Î³.

Cutting edge: impaired MHC class I expression in mice deficient for Nlrc5/class I transactivator.

Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells.

Transactivation of inducible nitric oxide synthase gene by Kruppel-like factor 6 regulates apoptosis during influenza A virus infection.

The T cell response to IL-10 alters cellular dynamics and paradoxically promotes central nervous system autoimmunity.

Innate IFN-Î³ is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection.

Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages.

Phenotypic and functional characterization of NK cells in human immune response against the dimorphic fungus Paracoccidioides brasiliensis.

Exosomes isolated from mycobacteria-infected mice or cultured macrophages can recruit and activate immune cells in vitro and in vivo.

IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms.

Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis.

Increased frequency of suppressive regulatory T cells and T cell-mediated antigen loss results in murine melanoma recurrence.

IFN-Î³-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

Innate instruction of CD4+ T cell immunity in respiratory bacterial infection.

B cell tolerance and positive selection in $lupus^{}$

Year: 2012 Volume: 189 Issue: 1

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	John, Alison E. Brightling, Christopher E. Knox, Alan J. Clifford, Rachel L.
Description	Country affiliation: United kingdom Author Affiliation: Clifford RL ( University of Nottingham, City Hospital, Nottingham, UK.)
Abstract	Vascular endothelial growth factor (VEGF), a key angiogenic molecule, is aberrantly expressed in several diseases including asthma where it contributes to bronchial vascular remodeling and chronic inflammation. Asthmatic human airway smooth muscle cells hypersecrete VEGF, but the mechanism is unclear. In this study, we defined the mechanism in human airway smooth muscle cells from nonasthmatic and asthmatic patients. We found that asthmatic cells lacked a repression complex at the VEGF promoter, which was present in nonasthmatic cells. Recruitment of G9A, trimethylation of histone H3 at lysine 9 (H3K9me3), and a resultant decrease in RNA polymerase II at the VEGF promoter was critical to repression of VEGF secretion in nonasthmatic cells. At the asthmatic promoter, H3K9me3 was absent because of failed recruitment of G9a; RNA polymerase II binding, in association with TATA-binding protein-associated factor 1, was increased; H3K4me3 was present; and Sp1 binding was exaggerated and sustained. In contrast, DNA methylation and histone acetylation were similar in asthmatic and nonasthmatic cells. This is the first study, to our knowledge, to show that airway cells in asthma have altered epigenetic regulation of remodeling gene(s). Histone methylation at genes such as VEGF may be an important new therapeutic target.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1103641
Journal	The Journal of Immunology
Issue Number	2
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-07-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Asthma Metabolism Pathology Bronchi Dna Methylation Histones Myocytes, Smooth Muscle Up-regulation Immunology Vascular Endothelial Growth Factor A Airway Remodeling Genetics Secretion Cells, Cultured Protein Isoforms Transcription, Genetic Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in