NDLI: Platelets present antigen in the context of MHC class I.

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The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells.

Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells.

Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages.

IFN-Î³ elicits macrophage autophagy via the p38 MAPK signaling pathway.

Recruitment of memory B cells to lymph nodes remote from the site of immunization requires an inflammatory stimulus.

Polar opposites: Erk direction of CD4 T cell subsets.

Activation of invariant NKT cells in early phase of experimental autoimmune encephalomyelitis results in differentiation of Ly6Chi inflammatory monocyte to M2 macrophages and improved outcome.

Leishmania donovani exploits host deubiquitinating enzyme A20, a negative regulator of TLR signaling, to subvert host immune response.

Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.

Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation.

A role for the NF-κB pathway in cell protection from complement-dependent cytotoxicity.

Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.

Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumonia.

Breakdown in repression of IFN-Î³ mRNA leads to accumulation of self-reactive effector CD8+ T cells.

HIV-1 infection of human intestinal lamina propria CD4+ T cells in vitro is enhanced by exposure to commensal Escherichia coli.

Human antitumor CD8+ T cells producing Th1 polycytokines show superior antigen sensitivity and tumor recognition.

Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma.

EWI-2 association with -actinin regulates T cell immune synapses and HIV viral infection.

Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease.

Identification, cloning, and functional characterization of the IL-1 receptor antagonist in the chicken reveal important differences between the chicken and mammals.

Retinoic acid attenuates rheumatoid inflammation in mice.

Expression, regulation, and function of atypical chemerin receptor CCRL2 on endothelial cells.

Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.

Identification of protective B cell antigens of Legionella pneumophila.

In vivo VL-targeted microbial superantigen induced global shifts in the B cell repertoire.

Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.

Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection.

Structural characterization and inhibitory profile of formyl peptide receptor 2 selective peptides descending from a PIP2-binding domain of gelsolin.

Gemfibrozil, a lipid-lowering drug, upregulates IL-1 receptor antagonist in mouse cortical neurons: implications for neuronal self-defense.

Platelets present antigen in the context of MHC class I.

Differential idiotype utilization for the in vivo type 14 capsular polysaccharide-specific immunoglobulin responses to intact Streptococcus pneumoniae versus a pneumococcal conjugate vaccine

TGF-ß mediates proinflammatory seminal fluid signaling in human cervical epithelial cells.

Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model.

Molecular mechanisms responsible for the selective and low-grade induction of proinflammatory mediators in murine macrophages by lipopolysaccharide.

The efficiency of human cytomegalovirus pp65(495-503) CD8+ T cell epitope generation is determined by the balanced activities of cytosolic and endoplasmic reticulum-resident peptidases.

Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production.

Defective macrophage migration in G i2- but not G i3-deficient mice.

CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl.

Cutting edge: mast cells critically augment myeloid-derived suppressor cell activity.

Tim-3 pathway controls regulatory and effector T cell balance during hepatitis C virus infection.

Autocrine IFN-Î³ promotes naive CD8 T cell differentiation and synergizes with IFN- to stimulate strong function.

Transient low-dose methotrexate induces tolerance to murine anti-thymocyte globulin and together they promote long-term allograft survival.

NK1.1+ cells and IL-22 regulate vaccine-induced protective immunity against challenge with Mycobacterium tuberculosis.

TNFR-associated factor 2 deficiency in B lymphocytes predisposes to chronic lymphocytic leukemia/small lymphocytic lymphoma in mice.

A computational model for early events in B cell antigen receptor signaling: analysis of the roles of Lyn and Fyn.

Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor Î³.

Cutting edge: impaired MHC class I expression in mice deficient for Nlrc5/class I transactivator.

Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells.

Transactivation of inducible nitric oxide synthase gene by Kruppel-like factor 6 regulates apoptosis during influenza A virus infection.

The T cell response to IL-10 alters cellular dynamics and paradoxically promotes central nervous system autoimmunity.

Innate IFN-Î³ is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection.

Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages.

Phenotypic and functional characterization of NK cells in human immune response against the dimorphic fungus Paracoccidioides brasiliensis.

Exosomes isolated from mycobacteria-infected mice or cultured macrophages can recruit and activate immune cells in vitro and in vivo.

IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms.

Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis.

Increased frequency of suppressive regulatory T cells and T cell-mediated antigen loss results in murine melanoma recurrence.

IFN-Î³-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

Innate instruction of CD4+ T cell immunity in respiratory bacterial infection.

B cell tolerance and positive selection in $lupus^{}$

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Platelets present antigen in the context of MHC class I.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chapman, Lesley M. Baldwin, William M. Field, David J. Srivastava, Kalyan Yui, Katsuyuki Morrell, Craig N. Aggrey, Angela A. Topham, David J. Ture, Sara
Description	Country affiliation: United States Author Affiliation: Chapman LM ( Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.)
Abstract	Platelets are most recognized for their vital role as the cellular mediator of thrombosis, but platelets also have important immune functions. Platelets initiate and sustain vascular inflammation in many disease conditions, including arthritis, atherosclerosis, transplant rejection, and severe malaria. We now demonstrate that platelets express T cell costimulatory molecules, process and present Ag in MHC class I, and directly activate naive T cells in a platelet MHC class I-dependent manner. Using an experimental cerebral malaria mouse model, we also demonstrate that platelets present pathogen-derived Ag to promote T cell responses in vivo, and that platelets can be used in a cell-based vaccine model to induce protective immune responses. Our study demonstrates a novel Ag presentation role for platelets.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1200580
Journal	The Journal of Immunology
Issue Number	2
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-07-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigen Presentation Immunology Blood Platelets Histocompatibility Antigens Class I Animals Metabolism Parasitology Cd8-positive T-lymphocytes Pathology Cell Movement Blood Genetics Lymphocyte Activation Malaria Mice Mice, Inbred C57bl Plasmodium Berghei Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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