NDLI: Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Moss, Paul A. H. Piper, Karen Goodyear, Oliver Lissauer, David Kilby, Mark D.
Description	Country affiliation: United kingdom Author Affiliation: Lissauer D ( School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, UK. d.m.lissauer@bham.ac.uk)
Abstract	Tolerance of the semiallogeneic fetus presents a significant challenge to the maternal immune system during human pregnancy. T cells with specificity for fetal epitopes have been detected in women with a history of previous pregnancy, but it has been thought that such fetal-specific cells were generally deleted during pregnancy as a mechanism to maintain maternal tolerance of the fetus. We used MHC-peptide dextramer multimers containing an immunodominant peptide derived from HY to identify fetal-specific T cells in women who were pregnant with a male fetus. Fetal-specific CD8(+) T lymphocytes were observed in half of all pregnancies and often became detectable from the first trimester. The fetal-specific immune response increased during pregnancy and persisted in the postnatal period. Fetal-specific cells demonstrated an effector memory phenotype and were broadly functional. They retained their ability to proliferate, secrete IFN-Î³, and lyse target cells following recognition of naturally processed peptide on male cells. These data show that the development of a fetal-specific adaptive cellular immune response is a normal consequence of human pregnancy and that unlike reports from some murine models, fetal-specific T cells are not deleted during human pregnancy. This has broad implications for study of the natural physiology of pregnancy and for the understanding of pregnancy-related complications.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	2
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-07-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Embryonic Stem Cells Immunology Metabolism Epitopes, T-lymphocyte Fetus T-lymphocytes, Cytotoxic Adaptive Immunity Clone Cells Cytotoxicity Tests, Immunologic Cytology Blood H-y Antigen Hla-a2 Antigen Immunophenotyping Minor Histocompatibility Antigens Pregnancy Protein Multimerization Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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