NDLI: The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lin, Yung-Chang Day, Yuan-Ji Chen, Tse-Ching Chu, Yu-Yi Huang, Ching-Tai Chang, Li-Yuan Hsu, Chen-Yu Kang, Chiao-Wen Lin, Chun-Yen Yeh, Chau-Ting
Description	Country affiliation: Taiwan Author Affiliation: Chang LY ( College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan.)
Abstract	CD103 is a marker for identification of effector/memory regulatory T cells (Tregs). CD103(+) Tregs are potent suppressors of tissue inflammation in several infectious diseases, autoimmune diseases, and cancers. However, the underlying mechanisms for this potent suppression ability remain unclear. The current study was designed to clarify this issue. Unexpectedly, we found both CD103(+) and CD103(-) Tregs had similar suppression capacity in vitro. We then chose a murine tumor model for investigation of the in vivo behavior of these Tregs. The suppression ability in vivo against the anti-tumor ability of CD8(+) T cells was restricted to CD103(+) Tregs although both Tregs had equal in vitro suppression ability. In addition, CD103(+) Tregs expressed significantly higher levels of CCR5 than those of CD103(-) Tregs and accumulated more in tumors than did CD103(-) Tregs. Furthermore, blockade of CCR5 signaling, either by CCR5(-/-)CD103(+) Tregs or by CCL5 knockdown tumor, could reduce the migration of CD103(+) Tregs into tumors and impair their in vivo suppression ability. In conclusion, these results indicate that the potent in vivo suppression ability of CD103(+) Tregs is due to the tissue-migration ability through CCR5 expression.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	2
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-07-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Cd Biosynthesis Down-regulation Immunology Immunologic Memory Integrin Alpha Chains Receptors, Ccr5 Physiology T-lymphocytes, Regulatory Transplantation Adoptive Transfer Animals Administration & Dosage Cell Line, Tumor Cell Movement Genetics Mice Mice, Inbred Balb C Mice, Inbred C57bl Mice, Knockout Nih 3t3 Cells Deficiency Metabolism Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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