NDLI: Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life.

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Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nikolich-Zugich, Janko Smithey, Megan J. Davenport, Miles P. Li, Gang Venturi, Vanessa
Description	Country affiliation: United States Author Affiliation: Smithey MJ ( Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.)
Abstract	Persistent CMV infection has been associated with immune senescence. To address the causal impact of lifelong persistent viral infection on immune homeostasis and defense, we infected young mice systemically with HSV-1, murine CMV, or both viruses and studied their T cell homeostasis and function. Herpesvirus(+) mice exhibited increased all-cause mortality compared with controls. Upon Listeria-OVA infection, 23-mo-old animals that had experienced lifelong herpesvirus infections showed impaired bacterial control and CD8 T cell function, along with distinct alterations in the T cell repertoire both before and after Listeria challenge, compared with age-matched, herpesvirus-free controls. Herpesvirus infection was associated with reduced naive CD8 T cell precursors above the loss attributable to aging. Moreover, the OVA-specific CD8 T cell repertoire recruited after Listeria challenge was entirely nonoverlapping between control and herpesvirus(+) mice. To our knowledge, this study for the first time causally links lifelong herpesvirus infection to all-cause mortality in mice and to disturbances in the T cell repertoire, which themselves correspond to impaired immunity to a new infection in aging.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201867
Journal	The Journal of Immunology
Issue Number	11
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aging Immunology Cd8-positive T-lymphocytes Herpesviridae Infections Listeriosis Precursor Cells, T-lymphoid Animals Pathology Coinfection Virology Herpesvirus 1, Human Immunologic Memory Listeria Monocytogenes Genetics Microbiology Mice Muromegalovirus Ovalbumin Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Life-long persistent viral infection alters the naïve T-cell pool, impairing CD8 T-cell immunity in late life 1

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Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life.

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Life-long persistent viral infection alters the naïve T-cell pool, impairing CD8 T-cell immunity in late life 1

Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection.

Defective CD8 T cell memory following acute infection without CD4 T cell help.

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Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection.

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Cutting edge: memory CD8 T cell compartment grows in size with immunological experience but nevertheless can lose function.

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Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life.