NDLI: HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells.

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HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Matthews, Katie Chung, Nancy P. Y. Sanders, Rogier W. Moore, John P. Klasse, Per Johan
Description	Country affiliation: United States Author Affiliation: Chung NP ( Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021, USA.)
Abstract	Plasmacytoid dendritic cells (pDCs) play a central role in innate and adaptive immune responses to viral infections, including HIV type 1 (HIV-1). pDCs produce substantial quantities of type I IFN and proinflammatory cytokines upon stimulation via TLRs, specifically TLR7 or TLR9. The HIV-1 envelope glycoproteins, exemplified by the gp120 monomer, are the focus of vaccines aimed at inducing B cell responses. We have studied how the interactions of gp120 with various receptors on human pDCs affect the activation of these cells via TLR9 and their subsequent ability to stimulate B cells. We observed that IFN- production by pDCs in response to TLR9, but not TLR7, stimulation was reduced by exposure to gp120. Specifically, gp120 inhibited the CpG-induced maturation of pDCs and their expression of TNF- , IL-6, TLR9, IFN regulatory factor 7, and BAFF. Receptor-blocking and cross-linking studies showed that these inhibitory effects of gp120 were mediated by interactions with CD4 and mannose-binding C-type lectin receptors, but not with the chemokine receptors CCR5 and CXCR4. Of note is that gp120 inhibited the activation of B cells by TLR9-stimulated pDCs. Taken together, our data show that HIV-1 gp120 impairs pDC functions, including activation of B cell responses, and imply that TLR9 ligands may not be good adjuvants to use in combination with envelope glycoprotein vaccines.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201905
Journal	The Journal of Immunology
Issue Number	11
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-lymphocytes Immunology Dendritic Cells Hiv Envelope Protein Gp120 Pharmacology Hiv-1 Oligodeoxyribonucleotides Toll-like Receptor 9 Antigens, Cd4 Genetics B-cell Activating Factor Drug Effects Virology Cell Communication Coculture Techniques Gene Expression Interferon Regulatory Factor-7 Interferon-alpha Biosynthesis Interleukin-6 Lymphocyte Activation Primary Cell Culture Recombinant Proteins Signal Transduction Toll-like Receptor 7 Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells.

HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells

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HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells

HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells

Plasmacytoid dendritic cell number and responses to Toll-like receptor 7 and 9 agonists vary in HIV Type 1-infected individuals in relation to clinical state.

HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells

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HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells.

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HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells.