NDLI: Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vidal, Elisabeth Fauchais, Anne-Laure Chemin, Guillaume Lise, Marie-Claude Martel, Clothilde Marget, Pierre Sindou, Philippe Jaccard, Arnaud Delpy, Laurent Lalloué, Fabrice Troutaud, Danielle Jauberteau, Marie-Odile Saada, Sofiane
Description	Country affiliation: France Author Affiliation: Saada S ( Department of Immunology, University of Limoges, Equipe Accueil 3842, 87025 Limoges, France.)
Abstract	Neurotensin, a neuropeptide growth factor, and its two specific neurotensin receptors, NTSR1 and NTSR2, were shown to be expressed by human B cell lines. Another NTSR, sortilin, which is common to neurotensin and neurotrophins, was also detected as we have previously described. Neurotensin was functional in B cell lines; it induced their proliferation and inhibited apoptosis induced by serum deprivation or Fas activation. Quantitative study of gene expression in two malignant B cell diseases showed that NTSR2 was overexpressed, NTSR1 decreased, and neurotensin was unexpressed in B cell leukemia patient's cells, as compared with healthy B cells. However, these expressions did not significantly change in large diffuse B cell lymphoma lymph nodes compared with benign ones. This study points out that neurotensin and its two specific receptors are expressed in human B lymphocytes. Such expressions were not described, and their relationship in B cell diseases, especially in chronic B cell leukemia, needs to be considered further in regard to these findings.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	11
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-lymphocytes Metabolism Gene Expression Regulation, Neoplastic Leukemia, Lymphocytic, Chronic, B-cell Genetics Lymphoma, Large B-cell, Diffuse Neurotensin Receptors, Neurotensin Antigens, Cd95 Apoptosis Pathology Carcinoma Case-control Studies Cell Line, Tumor Cell Proliferation Colonic Neoplasms Organ Specificity Primary Cell Culture Signal Transduction Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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