NDLI: Cutting edge: memory CD8 T cell compartment grows in size with immunological experience but nevertheless can lose function.

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Cutting edge: memory CD8 T cell compartment grows in size with immunological experience but nevertheless can lose function.

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Cutting edge: memory CD8 T cell compartment grows in size with immunological experience but nevertheless can lose function.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huster, Katharina M. Stemberger, Christian Gasteiger, Georg Kastenmüller, Wolfgang Drexler, Ingo Busch, Dirk H.
Description	Country affiliation: Germany Author Affiliation: Huster KM ( Institute for Medical Microbiology, Immunology, and Hygiene, Technical University Munich, 81675 Munich, Germany.)
Abstract	The size of the adaptive immune system is considered to be kept constant by the attrition of pre-existing memory. However, recently it was shown that the CD8 memory compartment can grow in size and the number of pre-existing memory is largely preserved, predicting that pre-existing immunity should be maintained (Vezys et al.; Nature 457: 196-199). Experimental proof for this assumption is still lacking. We address this question in the Listeria monocytogenes (L.m.) infection model and confirm the growth of size of the memory compartment by subsequent vaccination with modified vaccinia virus Ankara. We also find only modest attrition of pre-existing L.m.-specific memory CD8 T cells. However, pre-existing protective immunity toward L.m. is not preserved. Pre-existing L.m.-specific effector-memory cells, in contrast to central memory cells, become altered, and this results in a significant loss of pre-existing protective immunity. Our findings are clinically relevant for vaccines introducing new CD8 memory cells in high numbers, as this might influence pre-existing immunity.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	11
Volume Number	183
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2009-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd8-positive T-lymphocytes Immunology Immunologic Memory Listeriosis T-lymphocyte Subsets Vaccines Animals Cytology Listeria Monocytogenes Mice Mice, Inbred C57bl Vaccination Vaccinia Virus Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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