NDLI: Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist.

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Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Reis, Edimara S. Abe, Toshiharu Lambris, John D. Hajishengallis, Evlambia Hajishengallis, George Hosur, Kavita B. Ricklin, Daniel
Description	Country affiliation: United States Author Affiliation: Abe T ( Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.)
Abstract	When excessively activated or deregulated, complement becomes a major link between infection and inflammatory pathology including periodontitis. This oral inflammatory disease is associated with a dysbiotic microbiota, leads to the destruction of bone and other tooth-supporting structures, and exerts an adverse impact on systemic health. We have previously shown that mice deficient either in complement C5a receptor (C5aR; CD88) or TLR2 are highly and similarly resistant to periodontitis, suggesting that a cross-talk between the two receptors may be involved in the disease process. In this paper, we show that C5aR and TLR2 indeed synergize for maximal inflammatory responses in the periodontal tissue and uncover a novel pharmacological target to abrogate periodontitis. Using two different mouse models of periodontitis, we show that local treatments with a C5aR antagonist inhibited periodontal inflammation through downregulation of TNF, IL-1ß, IL-6, and IL-17 and further protected against bone loss, regardless of the presence of TLR2. These findings not only reveal a crucial cooperation between C5aR and TLR2 in periodontal inflammation but also provide proof-of-concept for local targeting of C5aR as a powerful candidate for the treatment of human periodontitis.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1202339
Journal	The Journal of Immunology
Issue Number	11
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bacteroidaceae Infections Drug Therapy Lipopeptides Administration & Dosage Peptides, Cyclic Periodontitis Porphyromonas Gingivalis Drug Effects Receptor, Anaphylatoxin C5a Antagonists & Inhibitors Animals Immunology Microbiology Down-regulation Drug Synergism Gingiva Immunity, Innate Injections Interleukin-17 Biosynthesis Interleukin-1beta Interleukin-6 Mice Receptor Cross-talk Metabolism Toll-like Receptor 2 Agonists Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist.

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