NDLI: Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection.

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Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Condotta, Stephanie A. Rai, Deepa James, Britnie R. Griffith, Thomas S. Badovinac, Vladimir P.
Description	Country affiliation: United States Author Affiliation: Condotta SA ( Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.)
Abstract	Patients who survive severe sepsis often display compromised immune function with impairment in innate and adaptive immune responses. These septic patients are highly susceptible to 'secondary' infections with intracellular pathogens that are usually controlled by CD8(+) T cells. It is not known when and if this observed immunoparalysis of CD8(+) T cell immunity recovers, and the long-term consequences of sepsis on the ability of naive CD8(+) T cells to respond to subsequent infections are poorly understood. In this study, using the cecal-ligation and puncture mouse model of sepsis, we show that sepsis induces a rapid loss of naive CD8(+) T cells. However, IL-15-dependent numerical recovery is observed a month after initial septic insult. Numerical recovery is accompanied by IL-15-dependent phenotypic changes where a substantial proportion of naive (Ag-inexperienced) CD8(+) T cells display a 'memory-like' phenotype (CD44(hi)/CD11a(hi)). Importantly, the impairment of naive CD8(+) T cells to respond to viral and bacterial infection was sustained for month(s) after sepsis induction. Incomplete recovery of naive CD8(+) T cell precursors was observed in septic mice, suggesting that the availability of naive precursors contributes to the sustained impairment in primary CD8(+) T cell responses. Thus, sepsis can result in substantial and long-lasting changes in the available CD8(+) T cell repertoire affecting the capacity of the host to respond to new infections.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1202379
Journal	The Journal of Immunology
Issue Number	5
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd8-positive T-lymphocytes Pathology Convalescence Listeriosis Lymphocytic Choriomeningitis Precursor Cells, T-lymphoid Sepsis Vaccinia Adoptive Transfer Animals Immunology Disease Models, Animal Immunity, Cellular Immunologic Memory Interleukin-15 Biosynthesis Listeria Monocytogenes Physiology Complications Microbiology Lymphocyte Count Virology Lymphocytic Choriomeningitis Virus Mice Mice, Transgenic Time Factors Vaccinia Virus Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s. Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection.

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Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection.