NDLI: Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection.

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Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection.

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Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Daudelin, Jean-François Savard, Pierre Leclerc, Denis Chartrand, Karine Kalinke, Ulrich Lebel, Marie-Ève Tarrab, Esther Lamarre, Alain Labrecque, Nathalie
Description	Author Affiliation: Lebel MÈ ( Laboratoire d'Immunovirologie, Institut National de la Recherche Scientifique, Institut Armand-Frappier, Laval, Quebec H7V 1B7, Canada)
Abstract	Developing new adjuvants and vaccination strategies is of paramount importance to successfully fight against many life-threatening infectious diseases and cancer. Very few adjuvants are currently authorized for human use, and these mainly stimulate a humoral response. However, specific Abs are not sufficient to confer protection against persisting infections or cancer. Therefore, development of adjuvants and immunomodulators able to enhance cell-mediated immune responses represents a major medical need. We recently showed that papaya mosaic virus nanoparticles (PapMV), self-assembled from the coat protein of a plant virus and a noncoding ssRNA molecule, are highly immunogenic in mice. PapMV can be used either as a vaccine delivery platform, through fusion of various epitopes to the coat protein or as adjuvant to enhance humoral immune responses against coadministered Ags or vaccines. However, the mechanisms that confer these immunomodulatory properties to PapMV and its ability to enhance T cell vaccines remain unknown. Using immunization studies in mice, we demonstrate in this paper that PapMV represents a novel TLR7 agonist with strong immunostimulatory properties. More importantly, pretreatment with PapMV significantly improves effector and memory CD8(+) T cell responses generated through dendritic cell vaccination increasing protection against a Listeria monocytogenes challenge.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	3
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adjuvants, Immunologic Cd8-positive T-lymphocytes Immunology Listeria Monocytogenes Listeriosis Prevention & Control Membrane Glycoproteins Agonists T-lymphocyte Subsets Toll-like Receptor 7 Tymovirus Vaccination Adaptive Immunity Animals Dendritic Cells Drug Evaluation, Preclinical Immunoglobulin G Biosynthesis Immunologic Memory Interferon Type I Deficiency Mice Mice, Inbred C57bl Myeloid Differentiation Factor 88 Nanoparticles Ovalbumin Rna, Viral Receptor, Interferon Alpha-beta Genetics Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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