NDLI: The proto-oncogene c-myc regulates antibody secretion and Ig class switch recombination.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ortiz, Maitane Martinez, Dolores Fernández, David Rodríguez, Lorena Moreno de Alborán, Ignacio García, Arancha
Description	Country affiliation: Spain Author Affiliation: Fernández D ( Departamento de Inmunología y Oncología, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Cientificas, Madrid E-28049, Spain.)
Abstract	The immune response involves the generation of Ab-secreting cells and memory B cells through a process called terminal B lymphocyte differentiation. This program requires the transcriptional repressor Blimp-1, which inhibits c-myc expression and terminates proliferation. Although the role of c-Myc in cell proliferation is well characterized, it is not known whether it has other functions in terminal differentiation. In this study, we show that c-Myc not only regulates cell proliferation, but it is also essential for Ab-secreting cell function and differentiation in vivo. c-Myc-deficient B lymphocytes hypersecrete IgM and do not undergo Ig class switch recombination (CSR). CSR has been previously linked to proliferation, and in this study we mechanistically link class switching and proliferation via c-Myc. We observed that c-Myc regulates CSR by transcriptionally activating the B cell-specific factor activation-induced cytidine deaminase. By linking cell proliferation and CSR, c-Myc is thus a critical component for a potent immune response.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	12
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-06-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibody Formation Immunology B-lymphocytes Immunoglobulin Class Switching Proto-oncogene Proteins C-myc Animals Cytology Metabolism Blotting, Western Cell Differentiation Cell Proliferation Cytidine Deaminase Enzyme-linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique Immunoprecipitation Mice Mice, Transgenic Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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