NDLI: IL-1 signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo.

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Developmental expression of IL-12Rß2 on murine naive neonatal T cells counters the upregulation of IL-13R 1 on primary Th1 cells and balances immunity in the newborn.

STAT4-dependent and -independent Th2 responses correlate with protective immunity against lung infection with Pneumocystis murina.

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PD-L1/B7-H1 regulates the survival but not the function of CD8+ T cells in herpes simplex virus type 1 latently infected trigeminal ganglia.

CXCR3 deficiency prolongs Th1-type contact hypersensitivity.

Markers of nonselective and specific NK cell activation.

Total parenteral nutrition-associated lamina propria inflammation in mice is mediated by a MyD88-dependent mechanism.

Early inhibition of IL-1ß expression by IFN-Î³ is mediated by impaired binding of NF-κB to the IL-1ß promoter but is independent of nitric oxide.

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MicroRNA let-7c regulates macrophage polarization.

Comparative analysis of monocyte subsets in the pig.

Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor.

Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota.

Adam8 limits the development of allergic airway inflammation in mice.

Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells.

Propofol inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1.

An essential role of antibodies in the control of Chikungunya virus infection.

Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1.

TLR3-triggered reactive oxygen species contribute to inflammatory responses by activating signal transducer and activator of transcription-1.

CD11c(high)CD8+ regulatory T cell feedback inhibits CD4 T cell immune response via Fas ligand-Fas pathway.

Glia maturation factor-Î³ negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages.

B lymphocyte 'original sin' in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice.

Human IL-2 mutein with higher antitumor efficacy than wild type IL-2.

Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and $C3(H_{2}O)$

Spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin A4 axis.

Accelerated turnover of MHC class II molecules in NOD mice is developmentally and environmentally regulated in vivo and dispensable for $autoimmunity^{}$

Control of chronic mycobacterium tuberculosis infection by CD4 KLRG1- IL-2-secreting central memory cells.

Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance.

Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent.

Pseudogout-associated inflammatory calcium pyrophosphate dihydrate microcrystals induce formation of neutrophil extracellular traps.

Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.

Assembly of the TLR2/6 transmembrane domains is essential for activation and is a target for prevention of sepsis.

Soluble CD27-pool in humans may contribute to T cell activation and tumor immunity.

A potential suppressive effect of natural antisense IL-1β RNA on lipopolysaccharide-induced IL-1β expression

Truncated form of TGF-ßRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice.

IL-1 signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo.

Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand.

Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3.

IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRÎ³Î´+ intraepithelial lymphocytes.

Profound impairment of adaptive immune responses by alkylating chemotherapy.

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Galectin-1-mediated suppression of Pseudomonas aeruginosa-induced corneal immunopathology.

SOCS3 regulates BAFF in human enterocytes under ribosomal stress.

Cross talk between follicular Th cells and tumor cells in human follicular lymphoma promotes immune evasion in the tumor microenvironment.

Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic Î³Î´ T lymphocytes to tumor beds.

Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-Î³-induced inflammatory responses and LXR-dependent gene expression.

Recent thymic emigrants and mature naive T cells exhibit differential DNA methylation at key cytokine loci.

Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells.

Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance.

CD40 mediates downregulation of CD32B on specific memory B cell populations in rheumatoid arthritis.

GB virus C particles inhibit T cell activation via envelope E2 protein-mediated inhibition of TCR signaling.

Proresolving and tissue-protective actions of annexin A1-based cleavage-resistant peptides are mediated by formyl peptide receptor 2/lipoxin A4 receptor.

MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression.

Programmed death-1 shapes memory phenotype CD8 T cell subsets in a cell-intrinsic manner.

The proto-oncogene c-myc regulates antibody secretion and Ig class switch recombination.

Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans.

Monocyte-derived IL-5 reduces TNF production by Mycobacterium tuberculosis-specific CD4 T cells during SIV/M. tuberculosis coinfection.

Pleiotropic potential of dehydroxymethylepoxyquinomicin for NF-κB suppression via reactive oxygen species and unfolded protein response.

A novel targeting therapy of malignant mesothelioma using anti-podoplanin antibody.

Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression.

Metabolic adaptation of neutrophils in cystic fibrosis airways involves distinct shifts in nutrient transporter expression.

Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells.

Y chromosome-linked B and NK cell deficiency in mice.

HLA class I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on subclass, by engaging FcÎ³Rs.

Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells.

Superantigen-induced steroid resistance depends on activation of phospholipase Cß2.

T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes.

Enhancement of CCL15 expression and monocyte adhesion to endothelial cells (ECs) after hypoxia/reoxygenation and induction of ICAM-1 expression by CCL15 via the JAK2/STAT3 pathway in ECs.

Comment on 'TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia'.

Comment on 'Induced IL-17-producing invariant NKT cells require activation in presence of TGF-ß and IL-1ß'.

Response to comment on 'Induced IL-17-producing invariant NKT cells require activation in presence of TGF-ß and IL-1ß'.

What is and what should always have been: long-lived plasma cells induced by T cell-independent antigens.

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IL-1 signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Barry, Kevin C. Vance, Russell E. Fontana, Mary F. Portman, Jonathan L. Dugan, Aisling S.
Description	Country affiliation: United States Author Affiliation: Barry KC ( Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.)
Abstract	Legionella pneumophila is an intracellular bacterial pathogen that is the cause of a severe pneumonia in humans called Legionnaires' disease. A key feature of L. pneumophila pathogenesis is the rapid influx of neutrophils into the lungs, which occurs in response to signaling via the IL-1R. Two distinct cytokines, IL-1 and IL-1ß, can stimulate the type I IL-1R. IL-1ß is produced upon activation of cytosolic sensors called inflammasomes that detect L. pneumophila in vitro and in vivo. Surprisingly, we find no essential role for IL-1ß in neutrophil recruitment to the lungs in response to L. pneumophila. Instead, we show that IL-1 is a critical initiator of neutrophil recruitment to the lungs of L. pneumophila-infected mice. We find that neutrophil recruitment in response to virulent L. pneumophila requires the production of IL-1 specifically by hematopoietic cells. In contrast to IL-1ß, the innate signaling pathways that lead to the production of IL-1 in response to L. pneumophila remain poorly defined. In particular, although we confirm a role for inflammasomes for initiation of IL-1ß signaling in vivo, we find no essential role for inflammasomes in production of IL-1 . Instead, we propose that a novel host pathway, perhaps involving inhibition of host protein synthesis, is responsible for IL-1 production in response to virulent L. pneumophila. Our results establish IL-1 as a critical initiator of the inflammatory response to L. pneumophila in vivo and point to an important role for IL-1 in providing an alternative to inflammasome-mediated immune responses in vivo.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1300100
Journal	The Journal of Immunology
Issue Number	12
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-06-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Inflammation Immunology Interleukin-1alpha Legionnaires' Disease Neutrophil Infiltration Signal Transduction Animals Enzyme-linked Immunosorbent Assay Flow Cytometry Legionella Pneumophila Mice Mice, Inbred C57bl Mice, Knockout Reverse Transcriptase Polymerase Chain Reaction Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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