NDLI: MicroRNA let-7c regulates macrophage polarization.

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MicroRNA let-7c regulates macrophage polarization.

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GB virus C particles inhibit T cell activation via envelope E2 protein-mediated inhibition of TCR signaling.

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Comment on 'TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia'.

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Response to comment on 'Induced IL-17-producing invariant NKT cells require activation in presence of TGF-ß and IL-1ß'.

What is and what should always have been: long-lived plasma cells induced by T cell-independent antigens.

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MicroRNA let-7c regulates macrophage polarization.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Gang Tan, Zheng Banerjee, Sami Abraham, Edward Icyuz, Mert Yang, Shanzhong Cui, Huachun Xie, Na
Description	Country affiliation: United States Author Affiliation: Banerjee S ( Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.)
Abstract	Macrophages demonstrate a high level of plasticity, with the ability to undergo dynamic transition between M1 and M2 polarized phenotypes. The role of microRNAs (miRNAs) in regulating macrophage polarization has been largely undefined. In this study, we found that miRNA let-7c is expressed at a higher level in M-BMM (M2 macrophages) than in GM-BMM (M1 macrophages). let-7c levels are also greater in alveolar macrophages from fibrotic lungs as compared with those from normal lungs. let-7c expression was decreased when M-BMM converted to GM-BMM, whereas it increased when GM-BMM converted to M-BMM. LPS stimulation reduced let-7c expression in M-BMM. We found that overexpression of let-7c in GM-BMM diminished M1 phenotype expression while promoting polarization to the M2 phenotype. In contrast, knockdown of let-7c in M-BMM promoted M1 polarization and diminished M2 phenotype expression. We found that let-7c targets C/EBP-Î´, a transcriptional factor that plays an important role in inflammatory response. Furthermore, we found that let-7c regulates bactericidal and phagocytic activities of macrophages, two functional phenotypes implicated in macrophage polarization. Our data suggest that the miRNA let-7c plays an important role in regulating macrophage polarization.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1202496
Journal	The Journal of Immunology
Issue Number	12
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-06-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Differentiation Immunology Cell Polarity Macrophages Cytology Micrornas Animals Blotting, Western Flow Cytometry Mice Mice, Inbred Balb C Mice, Inbred C57bl Phenotype Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Transfection Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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