NDLI: Adam8 limits the development of allergic airway inflammation in mice.

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Developmental expression of IL-12Rß2 on murine naive neonatal T cells counters the upregulation of IL-13R 1 on primary Th1 cells and balances immunity in the newborn.

STAT4-dependent and -independent Th2 responses correlate with protective immunity against lung infection with Pneumocystis murina.

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Total parenteral nutrition-associated lamina propria inflammation in mice is mediated by a MyD88-dependent mechanism.

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MicroRNA let-7c regulates macrophage polarization.

Comparative analysis of monocyte subsets in the pig.

Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor.

Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota.

Adam8 limits the development of allergic airway inflammation in mice.

Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells.

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Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1.

TLR3-triggered reactive oxygen species contribute to inflammatory responses by activating signal transducer and activator of transcription-1.

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Human IL-2 mutein with higher antitumor efficacy than wild type IL-2.

Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and $C3(H_{2}O)$

Spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin A4 axis.

Accelerated turnover of MHC class II molecules in NOD mice is developmentally and environmentally regulated in vivo and dispensable for $autoimmunity^{}$

Control of chronic mycobacterium tuberculosis infection by CD4 KLRG1- IL-2-secreting central memory cells.

Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance.

Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent.

Pseudogout-associated inflammatory calcium pyrophosphate dihydrate microcrystals induce formation of neutrophil extracellular traps.

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Assembly of the TLR2/6 transmembrane domains is essential for activation and is a target for prevention of sepsis.

Soluble CD27-pool in humans may contribute to T cell activation and tumor immunity.

A potential suppressive effect of natural antisense IL-1β RNA on lipopolysaccharide-induced IL-1β expression

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Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand.

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IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRÎ³Î´+ intraepithelial lymphocytes.

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Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model.

Galectin-1-mediated suppression of Pseudomonas aeruginosa-induced corneal immunopathology.

SOCS3 regulates BAFF in human enterocytes under ribosomal stress.

Cross talk between follicular Th cells and tumor cells in human follicular lymphoma promotes immune evasion in the tumor microenvironment.

Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic Î³Î´ T lymphocytes to tumor beds.

Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-Î³-induced inflammatory responses and LXR-dependent gene expression.

Recent thymic emigrants and mature naive T cells exhibit differential DNA methylation at key cytokine loci.

Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells.

Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance.

CD40 mediates downregulation of CD32B on specific memory B cell populations in rheumatoid arthritis.

GB virus C particles inhibit T cell activation via envelope E2 protein-mediated inhibition of TCR signaling.

Proresolving and tissue-protective actions of annexin A1-based cleavage-resistant peptides are mediated by formyl peptide receptor 2/lipoxin A4 receptor.

MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression.

Programmed death-1 shapes memory phenotype CD8 T cell subsets in a cell-intrinsic manner.

The proto-oncogene c-myc regulates antibody secretion and Ig class switch recombination.

Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans.

Monocyte-derived IL-5 reduces TNF production by Mycobacterium tuberculosis-specific CD4 T cells during SIV/M. tuberculosis coinfection.

Pleiotropic potential of dehydroxymethylepoxyquinomicin for NF-κB suppression via reactive oxygen species and unfolded protein response.

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Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression.

Metabolic adaptation of neutrophils in cystic fibrosis airways involves distinct shifts in nutrient transporter expression.

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Y chromosome-linked B and NK cell deficiency in mice.

HLA class I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on subclass, by engaging FcÎ³Rs.

Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells.

Superantigen-induced steroid resistance depends on activation of phospholipase Cß2.

T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes.

Enhancement of CCL15 expression and monocyte adhesion to endothelial cells (ECs) after hypoxia/reoxygenation and induction of ICAM-1 expression by CCL15 via the JAK2/STAT3 pathway in ECs.

Comment on 'TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia'.

Comment on 'Induced IL-17-producing invariant NKT cells require activation in presence of TGF-ß and IL-1ß'.

Response to comment on 'Induced IL-17-producing invariant NKT cells require activation in presence of TGF-ß and IL-1ß'.

What is and what should always have been: long-lived plasma cells induced by T cell-independent antigens.

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Adam8 limits the development of allergic airway inflammation in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gupta, Kushagra Craig, Vanessa J. Tesfaigzi, Yohannes Nakajima, Takahiro Fyfe, Susanne E. Sholl, Lynette Zahid, Muhammad Israel, Elliot Polverino, Francesca Montano, Gilbert Kobzik, Lester Hergrueter, Anja Knolle, Martin D. Permaul, Perdita Owen, Caroline A. Cernadas, Manuela
Description	Country affiliation: United States Author Affiliation: Knolle MD ( Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.)
Abstract	To determine whether a disintegrin and metalloproteinase-8 (Adam8) regulates allergic airway inflammation (AAI) and airway hyperresponsiveness (AHR), we compared AAI and AHR in wild-type (WT) versus Adam8(-/-) mice in different genetic backgrounds sensitized and challenged with OVA or house dust mite protein extract. OVA- and house dust mite-treated Adam8(-/-) mice had higher lung leukocyte counts, more airway mucus metaplasia, greater lung levels of some Th2 cytokines, and higher methacholine-induced increases in central airway resistance than allergen-treated WT mice. Studies of OVA-treated Adam8 bone marrow chimeric mice confirmed that leukocyte-derived Adam8 predominantly mediated Adam8's anti-inflammatory activities in murine airways. Airway eosinophils and macrophages both expressed Adam8 in WT mice with AAI. Adam8 limited AAI and AHR in mice by reducing leukocyte survival because: 1) Adam8(-/-) mice with AAI had fewer apoptotic eosinophils and macrophages in their airways than WT mice with AAI; and 2) Adam8(-/-) macrophages and eosinophils had reduced rates of apoptosis compared with WT leukocytes when the intrinsic (but not the extrinsic) apoptosis pathway was triggered in the cells in vitro. ADAM8 was robustly expressed by airway granulocytes in lung sections from human asthma patients, but, surprisingly, airway macrophages had less ADAM8 staining than airway eosinophils. Thus, ADAM8 has anti-inflammatory activities during AAI in mice by activating the intrinsic apoptosis pathway in myeloid leukocytes. Strategies that increase ADAM8 levels in myeloid leukocytes may have therapeutic efficacy in asthma.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1202329
Journal	The Journal of Immunology
Issue Number	12
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-06-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adam Proteins Immunology Antigens, Cd Asthma Bronchial Hyperreactivity Membrane Proteins Metabolism Animals Apoptosis Pathology Disease Models, Animal Eosinophils Fluorescent Antibody Technique Macrophages Mice Mice, Inbred Balb C Mice, Inbred C57bl Mice, Knockout Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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