NDLI: Profound impairment of adaptive immune responses by alkylating chemotherapy.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2013 Volume: 190 Issue: 12

Developmental expression of IL-12Rß2 on murine naive neonatal T cells counters the upregulation of IL-13R 1 on primary Th1 cells and balances immunity in the newborn.

STAT4-dependent and -independent Th2 responses correlate with protective immunity against lung infection with Pneumocystis murina.

Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits.

miR-142-3p is involved in CD25+ CD4 T cell proliferation by targeting the expression of glycoprotein A repetitions predominant.

Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.

Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice.

Proteolytic activation transforms heparin cofactor II into a host defense molecule.

Mechanism of IL-1ß modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation.

PD-L1/B7-H1 regulates the survival but not the function of CD8+ T cells in herpes simplex virus type 1 latently infected trigeminal ganglia.

CXCR3 deficiency prolongs Th1-type contact hypersensitivity.

Markers of nonselective and specific NK cell activation.

Total parenteral nutrition-associated lamina propria inflammation in mice is mediated by a MyD88-dependent mechanism.

Early inhibition of IL-1ß expression by IFN-Î³ is mediated by impaired binding of NF-κB to the IL-1ß promoter but is independent of nitric oxide.

Separation of function between isotype switching and affinity maturation in vivo during acute immune responses and circulating autoantibodies in UNG-deficient mice.

Immunization with biodegradable nanoparticles efficiently induces cellular immunity and protects against influenza virus infection.

Role of macrophage receptor with collagenous structure in innate immune tolerance.

Looped host defense peptide CLP-19 binds to microtubules and inhibits surface expression of TLR4 on mouse macrophages.

CD4+ T cells provide intermolecular help to generate robust antibody responses in vaccinia virus-vaccinated humans.

Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice.

MicroRNA let-7c regulates macrophage polarization.

Comparative analysis of monocyte subsets in the pig.

Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor.

Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota.

Adam8 limits the development of allergic airway inflammation in mice.

Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells.

Propofol inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1.

An essential role of antibodies in the control of Chikungunya virus infection.

Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1.

TLR3-triggered reactive oxygen species contribute to inflammatory responses by activating signal transducer and activator of transcription-1.

CD11c(high)CD8+ regulatory T cell feedback inhibits CD4 T cell immune response via Fas ligand-Fas pathway.

Glia maturation factor-Î³ negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages.

B lymphocyte 'original sin' in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice.

Human IL-2 mutein with higher antitumor efficacy than wild type IL-2.

Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and $C3(H_{2}O)$

Spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin A4 axis.

Accelerated turnover of MHC class II molecules in NOD mice is developmentally and environmentally regulated in vivo and dispensable for $autoimmunity^{}$

Control of chronic mycobacterium tuberculosis infection by CD4 KLRG1- IL-2-secreting central memory cells.

Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance.

Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent.

Pseudogout-associated inflammatory calcium pyrophosphate dihydrate microcrystals induce formation of neutrophil extracellular traps.

Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.

Assembly of the TLR2/6 transmembrane domains is essential for activation and is a target for prevention of sepsis.

Soluble CD27-pool in humans may contribute to T cell activation and tumor immunity.

A potential suppressive effect of natural antisense IL-1β RNA on lipopolysaccharide-induced IL-1β expression

Truncated form of TGF-ßRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice.

IL-1 signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo.

Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand.

Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3.

IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRÎ³Î´+ intraepithelial lymphocytes.

Profound impairment of adaptive immune responses by alkylating chemotherapy.

Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model.

Galectin-1-mediated suppression of Pseudomonas aeruginosa-induced corneal immunopathology.

SOCS3 regulates BAFF in human enterocytes under ribosomal stress.

Cross talk between follicular Th cells and tumor cells in human follicular lymphoma promotes immune evasion in the tumor microenvironment.

Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic Î³Î´ T lymphocytes to tumor beds.

Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-Î³-induced inflammatory responses and LXR-dependent gene expression.

Recent thymic emigrants and mature naive T cells exhibit differential DNA methylation at key cytokine loci.

Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells.

Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance.

CD40 mediates downregulation of CD32B on specific memory B cell populations in rheumatoid arthritis.

GB virus C particles inhibit T cell activation via envelope E2 protein-mediated inhibition of TCR signaling.

Proresolving and tissue-protective actions of annexin A1-based cleavage-resistant peptides are mediated by formyl peptide receptor 2/lipoxin A4 receptor.

MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression.

Programmed death-1 shapes memory phenotype CD8 T cell subsets in a cell-intrinsic manner.

The proto-oncogene c-myc regulates antibody secretion and Ig class switch recombination.

Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans.

Monocyte-derived IL-5 reduces TNF production by Mycobacterium tuberculosis-specific CD4 T cells during SIV/M. tuberculosis coinfection.

Pleiotropic potential of dehydroxymethylepoxyquinomicin for NF-κB suppression via reactive oxygen species and unfolded protein response.

A novel targeting therapy of malignant mesothelioma using anti-podoplanin antibody.

Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression.

Metabolic adaptation of neutrophils in cystic fibrosis airways involves distinct shifts in nutrient transporter expression.

Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells.

Y chromosome-linked B and NK cell deficiency in mice.

HLA class I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on subclass, by engaging FcÎ³Rs.

Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells.

Superantigen-induced steroid resistance depends on activation of phospholipase Cß2.

T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes.

Enhancement of CCL15 expression and monocyte adhesion to endothelial cells (ECs) after hypoxia/reoxygenation and induction of ICAM-1 expression by CCL15 via the JAK2/STAT3 pathway in ECs.

Comment on 'TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia'.

Comment on 'Induced IL-17-producing invariant NKT cells require activation in presence of TGF-ß and IL-1ß'.

Response to comment on 'Induced IL-17-producing invariant NKT cells require activation in presence of TGF-ß and IL-1ß'.

What is and what should always have been: long-lived plasma cells induced by T cell-independent antigens.

Year: 2013 Volume: 190 Issue: 11

Year: 2013 Volume: 190 Issue: 10

Year: 2013 Volume: 190 Issue: 9

Year: 2013 Volume: 190 Issue: 8

Year: 2013 Volume: 190 Issue: 7

Year: 2013 Volume: 190 Issue: 6

Year: 2013 Volume: 190 Issue: 5

Year: 2013 Volume: 190 Issue: 4

Year: 2013 Volume: 190 Issue: 3

Year: 2013 Volume: 190 Issue: 2

Year: 2013 Volume: 190 Issue: 1

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Profound impairment of adaptive immune responses by alkylating chemotherapy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dudek, Arkadiusz Z. Grinnen, Karen L. Hunt, Matthew A. Zellmer, David M. Ohlfest, John R. Litterman, Adam J. Salazar, Andres M.
Description	Country affiliation: United States Author Affiliation: Litterman AJ ( Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.)
Abstract	Overall, cancer vaccines have had a record of failure as an adjuvant therapy for malignancies that are treated with alkylating chemotherapy, and the contribution of standard treatment to that failure remains unclear. Vaccines aim to harness the proliferative potential of the immune system by expanding a small number of tumor-specific lymphocytes into a large number of antitumor effectors. Clinical trials are often conducted after treatment with alkylating chemotherapy, given either as standard therapy or for immunomodulatory effect. There is mounting evidence for synergy between chemotherapy and adoptive immunotherapy or vaccination against self-Ags; however, the impact of chemotherapy on lymphocytes primed against tumor neoantigens remains poorly defined. We report that clinically relevant dosages of standard alkylating chemotherapies, such as temozolomide and cyclophosphamide, significantly inhibit the proliferative abilities of lymphocytes in mice. This proliferative impairment was long-lasting and led to quantitative and qualitative defects in B and T cell responses to neoantigen vaccines. High-affinity responder lymphocytes receiving the strongest proliferative signals from vaccines experienced the greatest DNA damage responses, skewing the response toward lower-affinity responders with inferior functional characteristics. Together, these defects lead to inferior efficacy and overall survival in murine tumor models treated by neoantigen vaccines. These results suggest that clinical protocols for cancer vaccines should be designed to avoid exposing responder lymphocytes to alkylating chemotherapy.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1203539
Journal	The Journal of Immunology
Issue Number	12
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-06-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adaptive Immunity Drug Effects Antineoplastic Agents, Alkylating Toxicity Cancer Vaccines Administration & Dosage Neoplasms, Experimental Therapy Immunology Animals B-lymphocytes Combined Modality Therapy Enzyme-linked Immunosorbent Assay Flow Cytometry Mice Mice, Inbred C57bl Mice, Transgenic T-lymphocytes Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in