NDLI: Effect of disease severity on the performance of Cirrus spectral-domain OCT for glaucoma diagnosis.

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Effect of disease severity on the performance of Cirrus spectral-domain OCT for glaucoma diagnosis.

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Effect of disease severity on the performance of Cirrus spectral-domain OCT for glaucoma diagnosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Weinreb, Robert N. Alencar, Luciana M. Rao, Harsha L. Medeiros, Felipe A. Sample, Pamela A. Leite, Mauro T. Zangwill, Linda M.
Description	Country affiliation: United States Author Affiliation: Leite MT ( Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, California 92093-0946, USA.)
Abstract	PURPOSE: To evaluate the effect of disease severity on the diagnostic accuracy of the Cirrus Optical Coherence Tomograph (Cirrus HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA) for glaucoma detection. METHODS: One hundred thirty-five glaucomatous eyes of 99 patients and 79 normal eyes of 47 control subjects were recruited from the longitudinal Diagnostic Innovations in Glaucoma Study (DIGS). The severity of the disease was graded based on the visual field index (VFI) from standard automated perimetry. Imaging of the retinal nerve fiber layer (RNFL) was obtained using the optic disc cube protocol available on the Cirrus HD-OCT. Pooled receiver operating characteristic (ROC) curves were initially obtained for each parameter of the Cirrus HD-OCT. The effect of disease severity on diagnostic performance was evaluated by fitting an ROC regression model, with VFI used as a covariate, and calculating the area under the ROC curve (AUCs) for different levels of disease severity. RESULTS: The largest pooled AUCs were for average thickness (0.892), inferior quadrant thickness (0.881), and superior quadrant thickness (0.874). Disease severity had a significant influence on the detection of glaucoma. For the average RNFL thickness parameter, AUCs were 0.962, 0.932, 0.886, and 0.822 for VFIs of 70%, 80%, 90%, and 100%, respectively. CONCLUSIONS: Disease severity had a significant effect on the diagnostic performance of the Cirrus HD-OCT and thus should be considered when interpreting results from this device and when considering the potential applications of this instrument for diagnosing glaucoma in the various clinical settings.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.09-4716
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	51
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2010-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Axons Pathology Glaucoma, Open-angle Diagnosis Optic Disk Retinal Ganglion Cells Severity Of Illness Index Tomography, Optical Coherence Area Under Curve Case-control Studies Gonioscopy Roc Curve Reproducibility Of Results Sensitivity And Specificity Instrumentation Visual Field Tests Visual Fields Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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