NDLI: Tracking progression with spectral-domain optical coherence tomography in geographic atrophy caused by age-related macular degeneration.

Please wait, while we are loading the content...

Year: 2017 Volume: 58

Year: 2016 Volume: 57

Year: 2015 Volume: 56

Year: 2014 Volume: 56

Year: 2014 Volume: 55

Year: 2013 Volume: 54

Year: 2012 Volume: 53

Year: 2011 Volume: 52

Year: 2010 Volume: 51

Year: 2010 Volume: 51 Issue: 12

Year: 2010 Volume: 51 Issue: 11

Year: 2010 Volume: 51 Issue: 10

Year: 2010 Volume: 51 Issue: 9

Year: 2010 Volume: 51 Issue: 8

An experimental protocol of the model to quantify traction applied to the retina by vitreous cutters.

Measurement of ophthalmodynamometric pressure with the vented-gas forced-infusion system during pars plana vitrectomy.

Normal physiological and pathophysiological effects of trypan blue on the retinas of albino rabbits.

Surface topographies of glaucoma drainage devices and their influence on human tenon fibroblast adhesion.

Influence of corneal collagen crosslinking with riboflavin and ultraviolet-a irradiation on excimer laser surgery.

Use of single-vision distance spectacles improves landing control during step descent in well-adapted multifocal lens-wearers.

Correlation of relative afferent pupillary defect and retinal nerve fiber layer loss in unilateral or asymmetric demyelinating optic neuropathy.

A Comparison of Visual Field Sensitivity to Photoreceptor Thickness in Retinitis Pigmentosa

Gene expression profile of hyperoxic and hypoxic retinas in a mouse model of oxygen-induced retinopathy.

Changes in fibroblast mechanostat set point and mechanosensitivity: an adaptive response to mechanical stress in floppy eyelid syndrome.

Effects of optical defocus on refractive development in monkeys: evidence for local, regionally selective mechanisms.

Interferon gamma-inducible protein-10 (IP-10) and eotaxin as biomarkers in age-related macular degeneration.

Variable retinal phenotypes caused by mutations in the X-linked photopigment gene array.

High-resolution Fourier-domain optical coherence tomography of choroidal neovascular membranes associated with age-related macular degeneration.

Intravitreous delivery of the corticosteroid fluocinolone acetonide attenuates retinal degeneration in S334ter-4 rats.

Apelin in plasma and vitreous and in fibrovascular retinal membranes of patients with proliferative diabetic retinopathy.

Role of matrix metalloproteinase-9 in the development of diabetic retinopathy and its regulation by H-Ras.

Increased fundus autofluorescence associated with outer segment shortening in macular translocation model of neovascular age-related macular degeneration.

Identification and assessment of Schlemm's canal by spectral-domain optical coherence tomography.

Morphologic changes in the outflow pathways of bovine eyes treated with corticosteroids.

Effect of myopia on the thickness of the retinal nerve fiber layer measured by Cirrus HD optical coherence tomography.

Dynamic analysis of iris configuration with anterior segment optical coherence tomography.

VEGF-A165b is cytoprotective and antiangiogenic in the retina.

A hierarchy of endothelial colony-forming cell activity displayed by bovine corneal endothelial cells.

Adjusted peripapillary retinal nerve fiber layer thickness measurements based on the optic nerve head scan angle.

Recombinant human VEGF165b inhibits experimental choroidal neovascularization.

Identification of novel mutations in the ortholog of Drosophila eyes shut gene (EYS) causing autosomal recessive retinitis pigmentosa.

Purinergic receptors in the rat lens: activation of P2X receptors following hyperosmotic stress.

The relationship between phoria and the ratio of convergence peak velocity to divergence peak velocity.

ABCA4 and ROM1: implications for modification of the PRPH2-associated macular dystrophy phenotype.

Cytokine polymorphism in noninfectious uveitis.

Experimental intracameral injection of vancomycin microparticles in rabbits.

Role of insulin in regulation of Na+-/K+-dependent ATPase activity and pump function in corneal endothelial cells.

Culture, immortalization, and characterization of human meibomian gland epithelial cells.

The use of best visual acuity over several encounters as an outcome variable: an analysis of systematic bias.

Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking.

Inhibition by tranilast of the cytokine-induced expression of chemokines and the adhesion molecule VCAM-1 in human corneal fibroblasts.

Exogenous SOD mimetic tempol ameliorates the early retinal changes reestablishing the redox status in diabetic hypertensive rats.

An in vitro investigation of synergy or antagonism between antimicrobial combinations against isolates from bacterial keratitis.

Differential role of tumor necrosis factor (TNF)-alpha receptors in the development of choroidal neovascularization.

Corneal biomechanical changes after collagen cross-linking from porcine eye inflation experiments.

Fixation stability: a comparison between the Nidek MP-1 and the Rodenstock scanning laser ophthalmoscope in persons with and without diabetic maculopathy.

Cold-sensitive corneal afferents respond to a variety of ocular stimuli central to tear production: implications for dry eye disease.

In vitro efficacy of antifungal treatment using riboflavin/UV-A (365 nm) combination and amphotericin B.

Effect of disease severity on the performance of Cirrus spectral-domain OCT for glaucoma diagnosis.

The association between copy number variations in glutathione S-transferase M1 and T1 and age-related cataract in a Han Chinese population.

Phototoxicity of indocyanine green under continuous fluorescent lamp illumination and its prevention by blocking red light on cultured Müller cells.

Chemokine levels in subretinal fluid obtained during scleral buckling surgery after rhegmatogenous retinal detachment.

Global gene expression changes in rat retinal ganglion cells in experimental glaucoma.

Tracking progression with spectral-domain optical coherence tomography in geographic atrophy caused by age-related macular degeneration.

Effects of topical phenylephrine and tafluprost on optic nerve head circulation in monkeys with unilateral experimental glaucoma.

Linkage of posterior amorphous corneal dystrophy to chromosome 12q21.33 and exclusion of coding region mutations in KERA, LUM, DCN, and EPYC.

The cellular expression of antiangiogenic factors in fetal primate macula.

Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma.

Characterization of retinal and blood mitochondrial DNA from age-related macular degeneration patients.

Macular thickness variations with sex, age, and axial length in healthy subjects: a spectral domain-optical coherence tomography study.

Pathway-focused arrays reveal increased matrix metalloproteinase-7 (matrilysin) transcription in trachomatous trichiasis.

Immunolocalization of gap junction protein connexin43 (GJA1) in the human retina and optic nerve.

Fixation-free assessment of the Hirschberg ratio.

C-terminal cleavage of DeltaNp63alpha is associated with TSA-induced apoptosis in immortalized corneal epithelial cells.

Modulation of factors affecting optic nerve head astrocyte migration.

In vivo evaluation of superior limbic keratoconjunctivitis using laser scanning confocal microscopy and conjunctival impression cytology.

The differential effect of ultraviolet light exposure on cataract rate across regions of the lens.

Choroidal blood flow and progression of age-related macular degeneration in the fellow eye in patients with unilateral choroidal neovascularization.

Ubiquitin proteasome pathway-mediated degradation of proteins: effects due to site-specific substrate deamidation.

Motion-encoded MRIs provide evidence against orbital pulleys.

Donor cell survival in corneal grafts.

Year: 2010 Volume: 51 Issue: 7

Year: 2010 Volume: 51 Issue: 6

Year: 2010 Volume: 51 Issue: 5

Year: 2010 Volume: 51 Issue: 4

Year: 2010 Volume: 51 Issue: 3

Year: 2010 Volume: 51 Issue: 2

Year: 2010 Volume: 51 Issue: 1

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Tracking progression with spectral-domain optical coherence tomography in geographic atrophy caused by age-related macular degeneration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Eter, Nicole Fleckenstein, Monika Krämer, Irene Charbel Issa, Peter Helb, Hans Martin Holz, Frank G. Schmitz-Valckenberg, Steffen Brinkmann, Christian K. Adrion, Christine Mansmann, Ulrich
Description	Country affiliation: Germany Author Affiliation: Fleckenstein M ( Department of Ophthalmology, University of Bonn, Bonn, Germany.)
Abstract	PURPOSE: To investigate, with the use of spectral-domain optical coherence tomography (SD-OCT), microstructural alterations over time in eyes with progressive geographic atrophy (GA) due to age-related macular degeneration. METHODS: Forty-six eyes of 26 patients (median age, 77.9 years [interquartile range (IQR), 71.8-81.0]) with GA without evidence of active or previous neovascular disease at baseline were examined by simultaneous confocal scanning laser ophthalmoscopy (cSLO) and SD-OCT. Serial examinations with alignment of follow-up to baseline scans were performed over a median period of 12.2 months (IQR, 10.2-15.3). Longitudinal SD-OCT variations were evaluated, including quantification of retinal thickness (RT) change and lateral spread of GA (LSGA) at a temporal, nasal, inferior, and superior GA border-section in each eye. RESULTS: GA-enlargement was characterized by progressive loss of the outer hyperreflective SD-OCT bands and by thinning of the outer nuclear layer with subsequent approach of the outer plexiform layer toward Bruch's membrane. In the perilesional zone, various dynamic changes were recorded, including migration of hyperreflective material and changes in drusen height. At the borders, there was a median RT change of -14.09 microm/y (IQR -26.21 to -7.48 microm/y). The median LSGA was 106.90 microm/y (IQR, 55.44-161.70 microm/y). Both parameters showed only moderate intraocular agreement (RT change: intraclass correlation coefficient [ICC], 0.54; 95% CI, 0.39-0.67; LSGA: ICC, 0.49; 95% CI, 0.34-0.64) and no statistical significant difference for one location (RT change, P = 0.125; LSGA, P = 0.516; likelihood ratio test). CONCLUSIONS: Combined cSLO and SD-OCT imaging provides unprecedented insight into dynamic microstructural changes of GA enlargement that may help to better understand the pathogenesis of the disease. Quantitative progression data indicate local factors may exist that drive progression in junctional areas (ClinicalTrials.gov number, NCT00393692).
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	51
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2010-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Geographic Atrophy Diagnosis Macular Degeneration Retina Pathology Retinal Pigment Epithelium Tomography, Optical Coherence Disease Progression Etiology Physiopathology Complications Ophthalmoscopy Prospective Studies Clinical Trial Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in