NDLI: The differential effect of ultraviolet light exposure on cataract rate across regions of the lens.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Abraham, Alison G. West, Sheila Cox, Christopher
Spatial Coverage	Maryland
Description	Country affiliation: United States Author Affiliation: Abraham AG ( Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA. aabraham@jhsph.edu)
Abstract	PURPOSE: In studies of cortical cataract, a severity score representing the area covered by cataract is often used as the primary outcome. However, additional disease information may exist in the spatial distribution of opacities. Further, it has been hypothesized that the lower nasal region of the lens is the most susceptible to damage by environmental ultraviolet light exposure. METHODS: In a sample of 107 lens images from the Salisbury Eye Evaluation Study, a digital cortical cataract grading algorithm was used to capture the location of opacities in binary images. These images were used to estimate the severity of cataract in 16 regions around the lens. The effect of individual cumulative lifetime ocular exposure to ultraviolet B light on cortical cataract risk for each lens region was examined, as estimated by using an empiric model and baseline occupation and leisure activities data, in a linear mixed-effects model. RESULTS: The lower nasal regions had the highest cortical cataract severity in both the right and left eyes. In the combined data, region 9 (the lower nasal corner of the lens) was estimated to have the highest severity. In an assessment of the high- and low-exposure ultraviolet light groups (dichotomized at the median exposure level), higher exposure had the most effect in the lower regions of the lens. CONCLUSIONS: These results indicate that there are regional lens differences in the association between cataract and exposure to ultraviolet light but that ultraviolet light may not entirely explain the variations in cortical cataract severity across the lens.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.09-4557
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	51
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2010-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cataract Epidemiology Lens, Crystalline Radiation Effects Radiation Injuries Ultraviolet Rays Algorithms Diagnosis Image Processing, Computer-assisted Maryland Occupations Questionnaires Research Support, N.i.h., Extramural Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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The Differential Effect of Ultraviolet Light Exposure on Cataract Rate across Regions of the Lens

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The differential effect of ultraviolet light exposure on cataract rate across regions of the lens.

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The Differential Effect of Ultraviolet Light Exposure on Cataract Rate across Regions of the Lens

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