NDLI: A novel method to detect local ganglion cell loss in early glaucoma using spectral-domain optical coherence tomography.

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A novel method to detect local ganglion cell loss in early glaucoma using spectral-domain optical coherence tomography.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Morooka, Satoshi Yoshimura, Nagahisa Durbin, Mary Akagi, Tadamichi Nakano, Noriko Takayama, Kohei Hangai, Masanori Ikeda, Hanako Ohashi
Description	Country affiliation: Japan Author Affiliation: Takayama K ( Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.)
Abstract	PURPOSE: To test the glaucoma-discriminating ability of a new method for detecting local ganglion cell loss using spectral-domain optical coherence tomography (OCT). METHODS: This study included 58 glaucomatous and 48 healthy eyes from Japanese subjects. Combined thickness of the ganglion cell layer and inner plexus layer (GCIPL) was measured on a macular cube scan in Cirrus HD-OCT. Average GCIPL thickness within a macular elliptical annulus and minimum GCIPL thickness on 360 spokes extending from the inner to the outer radius of the elliptical annulus were calculated. Area under the receiver operating characteristic curve (AROC) to discriminate between healthy eyes and early (mean deviation [MD], ≥-6 dB)/advanced (MD, <-6 dB) glaucomatous were compared between parameters. RESULTS: Forty-three were normal-tension glaucoma, and 15 were high-tension glaucoma. The mean minimum GCIPL thickness was 77.0 µm in healthy eyes and 60.6 µm in glaucomatous eyes (P < 0.001). For the intersession repeatability, the coefficients of variation for average GCIPL and minimum GCIPL were 0.98 and 1.85 in glaucomatous eyes, and 0.89 and 1.85 in healthy eyes, respectively. Minimum GCIPL thickness AROC (0.896) was significantly higher (P = 0.0062) than average GCIPL thickness (0.821) for early glaucoma, whereas minimum GCIPL AROC (0.991) was comparable (P = 0.103) to average GCIPL (0.964) for advanced glaucoma. The minimum GCIPL thickness AROC was comparable (P = 0.861) to average circumpapillary retinal nerve fiber layer (cpRNFL) thickness (0.890) for early glaucoma. CONCLUSIONS: In Japanese patients with 74.1% of normal-tension glaucoma, the minimum GCIPL on spokes may be useful for detecting early glaucoma.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	11
Volume Number	53
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2012-10-05
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Diagnostic Techniques, Ophthalmological Low Tension Glaucoma Diagnosis Ocular Hypertension Retinal Ganglion Cells Pathology Tomography, Optical Coherence Algorithms Area Under Curve Cell Death Gonioscopy Intraocular Pressure Roc Curve Reproducibility Of Results Sensitivity And Specificity Tonometry, Ocular Visual Field Tests Visual Fields Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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