NDLI: Cirrus high-definition optical coherence tomography compared with Stratus optical coherence tomography in glaucoma diagnosis.

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Cirrus high-definition optical coherence tomography compared with Stratus optical coherence tomography in glaucoma diagnosis.

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Cirrus high-definition optical coherence tomography compared with Stratus optical coherence tomography in glaucoma diagnosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zarranz-Ventura, Javier García, Noelia Alvarez, Aurora Moreno-Montañés, Javier Olmo, Natalia
Description	Country affiliation: Spain Author Affiliation: Moreno-Montañés J ( Department of Ophthalmology, Clínica Universidad de Navarra, Pamplona, Spain. jmoreno@unav.es)
Abstract	PURPOSE: To compare the retinal nerve fiber layer (RNFL) evaluation using Cirrus optical coherence tomography (OCT) and Stratus OCT in glaucoma diagnosis. METHODS: One hundred thirty normal and 86 patients with glaucoma were included in this prospective study. The signal strengths of the OCTs were evaluated. The sensitivities and specificities of global RNFL average thickness were compared in the four quadrants and in each clock hour sector. Receiver operating characteristic (ROC) curves, areas under the ROC (AUC), and the likelihood ratio (LR) were plotted for RNFL thickness. Agreement between the OCTs was calculated by using the Bland-Altman method and kappa (kappa) coefficient. RESULTS: Twenty-three percent of all cases examined with Stratus OCT and 1.9% examined with Cirrus OCT had a signal strength below 6 (P = 0.01). In cases with signal strengths > or =6, the mean signal strength was higher with Cirrus OCT than with Stratus OCT (P = 0.01). The RNFL measurements by Cirrus were thicker than those of Stratus OCT (P < 0.05). The AUCs were 0.829 for Stratus and 0.837 for Cirrus OCT (P = 0.706) for global RNFL average. LRs were similar in both OCTs in global RNFL classification but varied in quadrants. The widths of the limits of agreement varied between 42.16 and 97.79 microm. There was almost perfect agreement (kappa = 0.82) in the average RNFL classification. CONCLUSIONS: Cirrus OCT has better scan quality than Stratus OCT, especially in glaucomatous eyes. In cases with good-quality scans, the sensitivity and specificity, and AUCs were similar. The best agreement was in the global average RNFL classification. The widths of limits of agreements exceed the limits of resolution of the OCTs.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	1
Volume Number	51
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2010-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Glaucoma, Open-angle Diagnosis Nerve Fibers Pathology Optic Disk Optic Nerve Diseases Retinal Ganglion Cells Tomography, Optical Coherence Area Under Curve Gonioscopy Intraocular Pressure Likelihood Functions Prospective Studies Roc Curve Sensitivity And Specificity Instrumentation Vision Disorders Visual Fields Comparative Study Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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