NDLI: Comparison of Cirrus OCT and Stratus OCT on the ability to detect localized retinal nerve fiber layer defects in preperimetric glaucoma.

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Comparison of Cirrus OCT and Stratus OCT on the ability to detect localized retinal nerve fiber layer defects in preperimetric glaucoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Park, Ki Ho Jeoung, Jin Wook
Description	Author Affiliation: Jeoung JW ( Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.)
Abstract	PURPOSE: To evaluate and compare the diagnostic ability of Cirrus and Stratus optical coherence tomography (OCT) to detect localized retinal nerve fiber layer (RNFL) defects in patients with normal standard automated perimetry. METHODS: This study included 55 eyes of 55 subjects with preperimetric localized RNFL defects and 55 normal control eyes of 55 age- and sex-matched subjects. Areas under the receiver operating characteristic curves (AUROCs) were calculated and compared. Based on the internal normative database from each device, the sensitivity and specificity for detecting preperimetric localized RNFL defects were calculated. RESULTS: There was no statistically significant difference between the AUROCs for the best parameters from the Cirrus OCT (inferior thickness, AUROC = 0.728) and Stratus OCT (7 o'clock sector, AUROC = 0.760; P = 0.477). The sensitivity of the Cirrus OCT parameters ranged from 21.0% to 87.1% and that of the Stratus OCT parameters ranged from 4.8% to 30.7%, with the criterion of abnormal at the 5% level. Based on the normative database, the highest Cirrus OCT sensitivity was obtained with the deviation-from-normal map (sensitivity 87.1% and specificity 61.8%), and the highest Stratus OCT sensitivity was obtained with the TSNIT thickness graph (sensitivity 30.7% and specificity 85.5%). CONCLUSIONS: There were no significant differences between the AUROCs for Cirrus and Stratus OCT, indicating that the two devices have similar diagnostic potentials in preperimetric glaucoma. After comparison with their normative databases, Cirrus OCT had generally higher sensitivities; however, this was largely at the cost of lower specificities than Stratus OCT.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	2
Volume Number	51
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2010-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Glaucoma Diagnosis Nerve Fibers Pathology Optic Disk Optic Nerve Diseases Retinal Ganglion Cells Tomography, Optical Coherence Area Under Curve Intraocular Pressure Physiology Likelihood Functions Roc Curve Refraction, Ocular Sensitivity And Specificity Tonometry, Ocular Visual Acuity Visual Field Tests Visual Fields Comparative Study Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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