NDLI: Relative flow volume, a novel blood flow index in the human retina derived from laser speckle flowgraphy.

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Relative flow volume, a novel blood flow index in the human retina derived from laser speckle flowgraphy.

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Relative flow volume, a novel blood flow index in the human retina derived from laser speckle flowgraphy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shiga, Yukihiro Nitta, Fumihiko Asano, Toshifumi Shimura, Masahiko Sato, Hajime Nakazawa, Toru Kunikata, Hiroshi
Description	Country affiliation: Japan Author Affiliation: Shiga Y ( Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan.); Asano T ( Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan.); Kunikata H ( Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan.); Nitta F ( Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan.); Sato H ( Department of Ophthalmology, Tohoku Rosai Hospital, Miyagi, Japan.); Nakazawa T ( Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan.); Shimura M ( Department of Ophthalmology, NTT East Japan Tohoku Hospital, Miyagi, Japan Department of Ophthalmology, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan.)
Abstract	PURPOSE: We investigated the accuracy and reproducibility of relative flow volume (RFV), a novel index of blood flow in the human retina derived from laser speckle flowgraphy (LSFG). METHODS: Pre- and postbranch retinal RFV measurements were compared in 34 retinal venous bifurcations in 34 healthy volunteers (mean age, 49.0 ± 14.8 years) to determine the accuracy of RFV. Next, the coefficient of variation (COV) of RFV was determined for 30 temporal retinal arteries in a second group of 18 healthy volunteers (mean age, 30.3 ± 7.7 years). Finally, laser Doppler velocimetry (LDV) data were obtained from the same study population and compared to RFV data from the retinal vessels. RESULTS: A comparison of RFV measurements in a trunk vessel of the retina and the sum of its two daughter vessels revealed a strong correlation (r = 0.98, P < 0.001). Reproducibility analysis showed that the COV for RFV was 5.9% ± 3.6%. Linear regression analysis revealed that RFV was correlated significantly with LDV measurements of mean retinal blood velocity (vmean) and retinal blood flow (FLDV, vmean, r = 0.61, P < 0.001; FLDV, r = 0.51, P = 0.004, respectively), but not significantly correlated with ocular perfusion pressure (r = -0.04, P = 0.76). CONCLUSIONS: These results suggest that RFV values obtained with LSFG can be considered an accurate and reliable index of relative blood flow in the human retina. Thus, RFV, a novel LSFG-derived variable, has potential for assessing retinal blood flow alterations in ocular disease.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	55
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2014-05-29
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Blood Flow Velocity Physiology Blood Volume Laser-doppler Flowmetry Retina Retinal Artery Retinal Vein Blood Pressure Intraocular Pressure Regional Blood Flow Reproducibility Of Results Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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