| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Zhou, Jibo Zhang, Leilei Jia, Yan Zhu, Dongqing Hu, Dan-Ning Fan, Xianqun Gu, Ping |
| Description |
Author Affiliation: Jia Y ( Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, People's Republic of China.); Hu DN ( Departments of Ophthalmology and Pathology, New York Eye and Ear Infirmary, New York, New York, United States.); Zhu D ( Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, People's Republic of China.); Zhang L ( Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, People's Republic of China.); Gu P ( Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, People's Republic of China.); Fan X ( Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, People's Republic of China.); Zhou J ( Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, People's Republic of China.) |
| Abstract |
PURPOSE: We measured the aqueous humor levels of matrix metalloproteinases (MMP) MMP-1, MMP-2, MMP-3, and tissue inhibitors of matrix metalloproteinases (TIMP) TIMP-1, TIMP-2, and TIMP-3 in patients with myopia or cataract, and investigated the relationship between their levels and axial length (AL). METHODS: We measured MMP/TIMPs levels with the Luminex xMAP Technology by using commercially available Milliplex xMAP Kits. A total of 65 aqueous humor samples was collected from patients with myopia or cataract during cataract or clear lens extraction surgery. According to the AL, the samples were divided into three groups: group A, AL ≤ 24 mm; group B, AL 24 to 26 mm; and group C, AL ≥ 26 mm. RESULTS: Levels of MMP-2, MMP-3, TIMP-1, TIMP-2, and TIMP-3 could be detected in the aqueous humor. The levels of MMP-2, TIMP-1, TIMP-2, and TIMP-3 were positively correlated with AL. The differences of the levels of these MMPs/TIMPs among the three groups were statistically significant. The MMP-3 levels were not correlated with AL and there was no significant difference in MMP-3 levels among these three groups. Levels of MMP-1 could not be detected in the aqueous humor samples. CONCLUSIONS: Elevated levels of aqueous MMP-2, TIMP-1, TIMP-2, and TIMP-3 were found in the eyes with elongated axis. |
| ISSN |
01460404 |
| e-ISSN |
15525783 |
| Journal |
Investigative Opthalmology & Visual Science |
| Issue Number |
6 |
| Volume Number |
55 |
| Language |
English |
| Publisher |
Association for Research in Vision and Ophthalmology |
| Publisher Date |
2014-05-29 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Aqueous Humor Enzymology Axial Length, Eye Matrix Metalloproteinase 2 Metabolism Matrix Metalloproteinase 3 Myopia Tissue Inhibitor Of Metalloproteinase-1 Tissue Inhibitor Of Metalloproteinase-2 Tissue Inhibitor Of Metalloproteinase-3 Cataract Immunoassay Interferometry Observational Study Research Support, Non-u.s. Gov't Discipline Ophthalmology |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Ophthalmology Sensory Systems Cellular and Molecular Neuroscience |
