NDLI: Eye movements and reading speed in macular disease: the shrinking perceptual span hypothesis requires and is supported by a mediation analysis.

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Eye movements and reading speed in macular disease: the shrinking perceptual span hypothesis requires and is supported by a mediation analysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Calabrèse, Aurélie Hoffart, Louis Castet, Eric Bernard, Jean-Baptiste Faure, Géraldine
Description	Country affiliation: United States Author Affiliation: Calabrèse A ( Minnesota Laboratory for Low-Vision Research, University of Minnesota, Minneapolis, United States.); Bernard JB ( Aix Marseille University, CNRS, LPC UMR 7290, Marseille, France.); Faure G ( Low Vision Clinic, University Hospital of La Timone, Marseille, France.); Hoffart L ( Department of Ophthalmology, University Hospital of La Timone, Marseille, France.); Castet E ( Aix Marseille University, CNRS, LPC UMR 7290, Marseille, France.)
Abstract	PURPOSE: Reading speed of patients with central field loss (CFL) correlates with the size of saccades (measured in letters per forward saccade [L/FS]). We assessed whether this effect is mediated by the total number of fixations, by the average fixation duration, or by a mixture of both. METHODS: We measured eye movements (with a video eye tracker) of 35 AMD and 4 Stargardt patients (better eye decimal acuity from 0.08-0.3) while they monocularly read single-line French sentences continuously displayed on a screen. All patients had a dense scotoma covering the fovea, as assessed with MP1 microperimetry, and therefore used eccentric viewing. Results were analyzed with regression-based mediation analysis, a modeling framework that informs on the underlying factors by which an independent variable affects a dependent variable. RESULTS: Reading speed and average fixation duration are negatively correlated, a result that was not observed in prior studies with CFL patients. This effect of fixation duration on reading speed is still significant when partialling out the effect of the total number of fixations (slope: -0.75, P < 0.001). Despite this large effect of fixation duration, mediation analysis shows that the effect of L/FS on reading speed is fully mediated by the total number of fixations (effect size: 0.96; CI [0.82, 1.12]) and not by fixation duration (effect size: 0.02; CI [-0.11, 0.14]). CONCLUSIONS: Results are consistent with the shrinking perceptual span hypothesis: reading speed decreases with the average number of letters traversed on each forward saccade, an effect fully mediated by the total number of fixations.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	55
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2014-05-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Eye Movements Physiology Macular Degeneration Physiopathology Scotoma Visual Acuity Visual Fields Visual Perception Eye Movement Measurements Complications Diagnosis Photic Stimulation Etiology Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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