NDLI: Macular choroidal thickness profile in a healthy population measured by swept-source optical coherence tomography.

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Macular choroidal thickness profile in a healthy population measured by swept-source optical coherence tomography.

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Macular choroidal thickness profile in a healthy population measured by swept-source optical coherence tomography.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Flores-Moreno, Ignacio Montero, Javier A. Peña-García, Pablo Ruiz-Medrano, Jorge Duker, Jay S. Ruiz-Moreno, José M.
Spatial Coverage	Japan
Description	Country affiliation: Spain Author Affiliation: Ruiz-Medrano J ( Clínico San Carlos University Hospital, Ophthalmology Unit, Madrid, Spain.); Flores-Moreno I ( Department of Ophthalmology, Castilla La Mancha University, Albacete, Spain.); Peña-García P ( Division of Ophthalmology, Miguel Hernández University, Alicante, Spain.); Montero JA ( Pío del Río Hortega University Hospital, Ophthalmology Unit, Valladolid, Spain.); Duker JS ( New England Eye Center, Tufts Medical Center, Boston, Massachusetts, United States.); Ruiz-Moreno JM ( Department of Ophthalmology, Castilla La Mancha University, Albacete, Spain Alicante Institute of Ophthalmology, Vissum, Vitreo-Retinal Unit, Alicante, Spain.)
Abstract	PURPOSE: To determine choroidal thickness (CT) profile in a healthy population using swept-source optical coherence tomography (SS-OCT). METHODS: This was a cross-sectional, noninterventional study. A total of 276 eyes (spherical equivalent ± 3 diopters [D]) were scanned with SS-OCT. Horizontal CT profile of the macula was created measuring subfoveal choroidal thickness (SFCT) from the posterior edge of retinal pigment epithelium (RPE) to the choroid-sclera junction. Three determinations were performed at successive points 1000 µm nasal and five more temporal to the fovea. Subjects were divided into five age groups. RESULTS: The mean SFCT was 301.89 ± 80.53 µm (95% confidence interval: 292.34-311.43). The mean horizontal macular choroidal thickness (MCT) was 258.69 ± 64.59 µm (95% confidence interval: 251.04-266.35). No difference in CT was found between men and women. Mean SFCT of the different study groups was 325.6 ± 51.1 (0-10 years), 316.7 ± 90.1 (11-20 years), 313.9 ± 80.3 (21-40 years), 264.6 ± 79.3 (41-60 years), and 276.3 ± 88.8 µm in subjects older than 60 years (P < 0.001; ANOVA test). Mean horizontal MCT was 286.0 ± 43.5, 277.7 ± 68.2, 264.0 ± 61.9, 223.4 ± 62.2, and 229.7 ± 66.1 µm, respectively (P < 0.001; ANOVA test). The CT profile was different for each age group. CONCLUSIONS: To our knowledge, this is the first population study of CT of healthy eyes across a broad range of age groups using SS-OCT. As has been determined using spectral-domain OCT, CT decreases with advancing age, especially after age 40. There were no differences due to sex. The greatest CT variation takes place in temporal sectors.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	55
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2014-05-20
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Choroid Diseases Diagnosis Choroid Cytology Macula Lutea Retinal Diseases Tomography, Optical Coherence Adolescent Child, Preschool Epidemiology Reference Values Reproducibility Of Results Multicenter Study Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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