NDLI: Transactivation of EGF receptors in chicken Müller cells by 2A-adrenergic receptors stimulated by brimonidine.

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Transactivation of EGF receptors in chicken Müller cells by 2A-adrenergic receptors stimulated by brimonidine.

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Transactivation of EGF receptors in chicken Müller cells by 2A-adrenergic receptors stimulated by brimonidine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Harun-Or-Rashid, Mohammad Lindqvist, Niclas Hallböök, Finn
Description	Country affiliation: Sweden Author Affiliation: Harun-Or-Rashid M ( Department of Neuroscience, Uppsala University, Uppsala, Sweden.); Lindqvist N ( Department of Neuroscience, Uppsala University, Uppsala, Sweden.); Hallböök F ( Department of Neuroscience, Uppsala University, Uppsala, Sweden.)
Abstract	PURPOSE: Alpha2-adrenergic receptor agonists are used in glaucoma treatment and have been shown to have some neuroprotective effects. We performed this study to test the hypothesis that epidermal growth factor receptors on chicken Müller cells are transactivated by 2-adrenergic receptors and we focused on the extracellular signal-activated kinases 1/2 (ERK) pathway. METHODS: Embryonic chicken retina and cultures of primary Müller cells were stimulated by 2-adrenergic receptor agonist brimonidine. Immunostaining, quantitative RT-PCR, and Western blot techniques, in combination with Src, epidermal growth factor receptor kinase, and matrix metalloproteinase inhibitors, were used for analysis of the cellular responses. RESULTS: Our results showed that Müller cells express 2A-adrenergic receptors in vivo and in vitro and that brimonidine triggered a robust and transient phosphorylation of ERK1/2. This ERK-response was Src-kinase dependent, associated with tyrosine phosphorylation of epidermal growth factor receptors (phospho-Y1068, Y1173) and was mediated by matrix metalloproteinase activity on the Müller cells. CONCLUSIONS: Müller cells express the 2A-adrenergic receptor, and brimonidine triggers both Src-kinase- and matrix metalloproteinase-mediated autocrine ligand-dependent activation of epidermal growth factor receptors on Müller cells. This response is consistent with transactivation of epidermal growth factor receptors by stimulation of 2-adrenergic receptors.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	55
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2014-04-29
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Ependymoglial Cells Metabolism Glaucoma Genetics Quinoxalines Pharmacology Receptor, Epidermal Growth Factor Retina Transcriptional Activation Adrenergic Alpha-2 Receptor Agonists Animals Blotting, Western Brimonidine Tartrate Cells, Cultured Chick Embryo Drug Effects Pathology Immunohistochemistry Map Kinase Signaling System Real-time Polymerase Chain Reaction Biosynthesis Receptors, Adrenergic, Alpha-2 Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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