NDLI: Individual larvae of the zebrafish mutant belladonna display multiple infantile nystagmus-like waveforms that are influenced by viewing conditions.

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Individual larvae of the zebrafish mutant belladonna display multiple infantile nystagmus-like waveforms that are influenced by viewing conditions.

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Individual larvae of the zebrafish mutant belladonna display multiple infantile nystagmus-like waveforms that are influenced by viewing conditions.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huber-Reggi, Sabina P. Mueller, Kaspar P. Straumann, Dominik Huang, Melody Ying-Yu Neuhauss, Stephan C. F.
Description	Country affiliation: Switzerland Author Affiliation: Huber-Reggi SP ( Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland Life Science Graduate School, Zurich, Switzerland.); Mueller KP ( Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.); Straumann D ( Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland Department of Neurology, University Hospital Zurich, Zurich, Switzerland.); Huang MY ( Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland Department of Neurology, University Hospital Zurich, Zurich, Switzerland.); Neuhauss SC ( Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.)
Abstract	PURPOSE: Infantile nystagmus syndrome (INS) is characterized by involuntary eye oscillations that can assume different waveforms. Previous attempts to uncover reasons for the presence of several nystagmus waveforms have not led to a general consensus in the community. Recently, we characterized the belladonna (bel) zebrafish mutant strain, in which INS-like ocular motor abnormalities are caused by misprojection of a variable fraction of optic nerve fibers. Here we studied intrinsic and extrinsic factors influencing the occurrence of different waveforms in bel larvae. METHODS: Eye movements of bel larvae were recorded in the presence of a stationary grating pattern. Waveforms of spontaneous oscillations were grouped in three categories: 'pendular,' 'unidirectional jerk,' and 'bidirectional jerk,' and the occurrences of each category were compared within and between individual larvae. Moreover, the effects of the characteristics of a preceding optokinetic response (OKR), of the field of view, and of the eye orbital position were analyzed. RESULTS: The different waveform categories co-occurred in most individuals. We found waveforms being influenced by the preceding OKR and by the field of view. Moreover, we found different kinds of relationships between orbital position and initiation of a specific waveform, including pendular nystagmus in a more eccentric orbital position, and differences among jerk oscillations regarding the beating direction of the first saccade or waveform amplitude. CONCLUSIONS: Our data suggest that waveform categories in bel larvae do not reflect the severity of the morphological phenotype but rather are influenced by viewing conditions.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	55
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2014-05-27
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Disease Models, Animal Lim-homeodomain Proteins Genetics Nerve Tissue Proteins Nystagmus, Congenital Physiopathology Nystagmus, Optokinetic Physiology Transcription Factors Zebrafish Proteins Zebrafish Animals Larva Mutation Nerve Fibers Optic Nerve Vision, Binocular Visual Fields Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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