NDLI: Enantioselective metabolism and toxic effects of metalaxyl on primary hepatocytes from rat.

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Enantioselective metabolism and toxic effects of metalaxyl on primary hepatocytes from rat.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Yao Zhu, Wentao Zhou, Zhiqiang Wang, Xinru Qiu, Jing Zhang, Ping
Description	Country affiliation: China Author Affiliation: Wang X ( Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Yuanmingyuan west road 2, Beijing, 100193, China.); Zhu W ( Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Yuanmingyuan west road 2, Beijing, 100193, China.); Qiu J ( Institute of Quality Standards and Testing Technology for Agro-Products, Key Laboratory of Agro-product Quality and SafetyBeijing, Chinese Academy of Agricultural Sciences, Beijing, China.); Zhang P ( Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Yuanmingyuan west road 2, Beijing, 100193, China.); Wang Y ( Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Yuanmingyuan west road 2, Beijing, 100193, China.); Zhou Z ( Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Yuanmingyuan west road 2, Beijing, 100193, China. zqzhou@cau.edu.cn.)
Abstract	Enantiomers of chiral compounds often exhibit enantioselective adverse effects and biochemical processes in non-target organisms. In this study, enantioselective metabolism and toxic effects of metalaxyl enantiomers on primary rat hepatocytes were investigated. Stereoselectivity was observed on both degradation of metalaxyl and formation of metabolites. (-)-R-metalaxyl eliminated faster than (+)-S-metalaxyl, while the hydroxylmetalaxyl, demethylmetalaxyl, and didemethylmetalaxyl metabolites derived from 50-µM (+)-S-metalaxyl after 24 h of incubation were approximately 1.57, 1.43, and 1.86 times more than that of (-)-R-metalaxyl, respectively. According to the methyl tetrazolium (MTT) assay, the EC50 values (24 h) for rac-, (+)-S-, and (-)-R-metalaxyl were 1788.22, 2066.73, and 2263.71 µM, respectively. An accordant enantioselective effect on oxidative stress suggested that the enantioselective cytotoxicity induced by metalaxyl enantiomers may partly contribute to enantioselective oxidative damage and mitochondrial dysfunction. Such results could be of great importance for credible environmental and toxicological risk assessment of metalaxyl.
ISSN	09441344
Issue Number	18
Journal	Environmental Science and Pollution Research
Volume Number	23
e-ISSN	16147499
Language	English
Publisher	Springer
Publisher Date	2016-09-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Science Discipline Environmental Chemistry
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

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