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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Liying Mao, Hui Peng, Yan Zhang, Zhongping Jin, Yang Zheng, Lei Zhao, Jiawei Du, Shuhu |
| Description | Country affiliation: China Author Affiliation: Zhang L ( School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China.); Jin Y ( School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China.); Mao H ( School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China.); Zheng L ( School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China.); Zhao J ( School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China.); Peng Y ( School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China.); Du S ( School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address: shuhudu@njmu.edu.cn.); Zhang Z ( Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui 230031, China. Electronic address: zpzhang@iim.ac.cn.) |
| Abstract | Trace penicilloic acid allergen frequently leads to various fatal immune responses to many patients, but it is still a challenge to directly discriminate and detect its residue in penicillin by a chemosensing way. Here, we report that silver-coated gold nanoparticles (Au@Ag NPs) exhibit a structure-selective hot-spot Raman enhancement capability for direct identification and detection of trace penicilloic acid in penicillin. It has been demonstrated that penicilloic acid can very easily link Au@Ag NPs together by its two carboxyl groups, locating itself spontaneously at the interparticle of Au@Ag NPs to form strong Raman hot-spot. At the critical concentration inducing the nanoparticle aggregation, Raman-enhanced effect of penicilloic acid is ~60,000 folds higher than that of penicillin. In particular, the selective Raman enhancement to the two carboxyl groups makes the peak of carboxyl group at C6 of penicilloic acid appear as a new Raman signal due to the opening of ß-lactam ring of penicillin. The surface-enhanced Raman scattering (SERS) nanoparticle sensor reaches a sensitive limit lower than the prescribed 1.0 penicilloic acid residue in penicillin. The novel strategy to examine allergen is more rapid, convenient and inexpensive than the conventional separation-based assay methods. |
| ISSN | 09565663 |
| Volume Number | 58 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-08-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Allergens Analysis Drug Evaluation, Preclinical Instrumentation Gold Chemistry Metal Nanoparticles Penicillanic Acid Analogs & Derivatives Penicillins Spectrum Analysis, Raman Drug Contamination Prevention & Control Methods Equipment Design Equipment Failure Analysis Ultrastructure Microchemistry Product Surveillance, Postmarketing Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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