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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Su, Wenqiong Ding, Xianting Li, Zonglin Liu, Shuopeng |
| Description | Author Affiliation: Li Z ( Med-x Research Institute, Shanghai Jiao Tong University, Shanghai 200240, PR China.); Su W ( School of Chemistry and Chemical Engineering, State Key Laboratory Metal Matrix Composities, Shanghai Jiao Tong University, Shanghai, 200240, PR China.); Liu S ( Med-x Research Institute, Shanghai Jiao Tong University, Shanghai 200240, PR China.); Ding X ( Med-x Research Institute, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address: dingxianting@sjtu.edu.cn.) |
| Abstract | Dihydronicotinamide adenine dinucleotide (NADH) is a major biomarker correlated with lethal diseases such as cancers and bacterial infection. Herein, we report a graphene-DNA tetrahedron-gold nanoparticle modified gold disk electrode for highly sensitive NADH detection. By assembling the DNA tetrahedron/graphene composite film on the gold disk electrode surface which prior harnessed electrochemical deposition of gold nanoparticles to enhance the effective surface area, the oxidation potential of NADH was substantially decreased to 0.28V (vs. Ag/AgCl) and surface fouling effects were successfully eliminated. Furthermore, the lower detection limit of NADH by the presented platform was reduced down to 1fM, with an upper limit of 10pM. Both the regeneration and selectivity of composite film-modified electrode are investigated and proved to be robust. The novel sensor developed here could serve as a highly sensitive probe for NADH detection, which would further benefit the field of NADH related disease diagnostics. |
| ISSN | 09565663 |
| Volume Number | 69 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Instrumentation Conductometry Dna Chemistry Graphite Metal Nanoparticles Nad Analysis Adsorption Electrodes Equipment Design Equipment Failure Analysis Gold Ultrastructure Reproducibility Of Results Sensitivity And Specificity Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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