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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kozma, Peter Stamm, Christoph Bier, Frank F. Kehl, Florian Ehrentreich-Förster, Eva |
| Description | Author Affiliation: Kozma P ( Fraunhofer Institute for Biomedical Engineering (IBMT), Am Mühlenberg 13, 14476 Potsdam-Golm, Germany. Electronic address: peter.kozma@ibmt.fraunhofer.de.); Kehl F ( Laboratory of Biosensors and Bioelectronics (LBB), Swiss Federal Institute of Technology (ETH), Gloriastrasse 35, 8092 Zürich, Switzerland.); Ehrentreich-Förster E ( Fraunhofer Institute for Biomedical Engineering (IBMT), Am Mühlenberg 13, 14476 Potsdam-Golm, Germany.); Stamm C ( Zurich University of Applied Sciences (ZHAW), School of Engineering, Institute of Applied Mathematics and Physics (IAMP), Technikumstrasse 9, 8400 Winterthur, Switzerland.); Bier FF ( Fraunhofer Institute for Biomedical Engineering (IBMT), Am Mühlenberg 13, 14476 Potsdam-Golm, Germany.) |
| Abstract | Integrated planar optical waveguide interferometer biosensors are advantageous combinations of evanescent field sensing and optical phase difference measurement methods. By probing the near surface region of a sensor area with the evanescent field, any change of the refractive index of the probed volume induces a phase shift of the guided mode compared to a reference field typically of a mode propagating through the reference arm of the same waveguide structure. The interfering fields of these modes produce an interference signal detected at the sensor׳s output, whose alteration is proportional to the refractive index change. This signal can be recorded, processed and related to e.g. the concentration of an analyte in the solution of interest. Although this sensing principle is relatively simple, studies about integrated planar optical waveguide interferometer biosensors can mostly be found in the literature covering the past twenty years. During these two decades, several members of this sensor family have been introduced, which have remarkably advantageous properties. These entail label-free and non-destructive detection, outstandingly good sensitivity and detection limit, cost-effective and simple production, ability of multiplexing and miniaturization. Furthermore, these properties lead to low reagent consumption, short analysis time and open prospects for point-of-care applications. The present review collects the most relevant developments of the past twenty years categorizing them into two main groups, such as common- and double path waveguide interferometers. In addition, it tries to maintain the historical order as it is possible and it compares the diverse sensor designs in order to reveal not only the development of this field in time, but to contrast the advantages and disadvantages of the different approaches and sensor families, as well. |
| ISSN | 09565663 |
| Volume Number | 58 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-08-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Instrumentation Interferometry Optical Devices Refractometry Surface Plasmon Resonance Equipment Design Equipment Failure Analysis Systems Integration Technology Assessment, Biomedical Comparative Study Journal Article Research Support, Non-u.s. Gov't Review Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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