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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sun, Xiaoyu Yu, Yanyan Wen, Xiangru Ou, Shanshan Yin, Xiaoxing Yu, Chao Yin, Tianxiao Zhang, Lin Tang, Daoquan |
| Description | Author Affiliation: Yu Y ( Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China.); Yu C ( Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China.); Yin T ( Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China.); Ou S ( Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China.); Sun X ( Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China.); Wen X ( College of Biomedical Sciences, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, PR China.); Zhang L ( Jiangsu Vcare Pharmatech Company, 15 Wanshou Road, Nanjing, Jiangsu 210000, PR China.); Tang D ( Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China. Electronic address: tdq993@126.com.); Yin X ( Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China. Electronic address: yinxx@xzmc.edu.cn.) |
| Abstract | An efficient ratiometric electrochemical biosensor for Cu determination was constructed using dual hydroxyl-functionalized poly (ionic liquid) (DHF-PIL) as the catalyst support. The DHF-PIL exhibited typical macroporous structure, which provided a high surface area of 39.31m /g for the sufficient loading of biomolecules. The specific recognition of Cu was accomplished by employing neurokinin B (NKB) for the first time, which could bind to Cu to form a [Cu (NKB) ] complex with high specificity. Meanwhile, a common redox mediator, 2, 2'-Azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS) was modified into DHF-PIL by electrostatic interactions to act as an inner reference molecule, which provided a built-in correction for environmental effects and improving the detection accuracy. With this strategy, the developed electrochemical biosensor was capable of determining Cu with a linear range between 0.9 and 36.1µM and low detection limit (LOD) and quantification limit (LOQ) of 0.24 and 0.6µM, respectively. The sensor also displayed a satisfactory selectivity against a series of interferences in the brain, including metal ions, amino acids and other endogenous compounds. Accordingly, the present biosensor was successfully applied to evaluate Cu levels in normal and AD rats. |
| ISSN | 09565663 |
| Volume Number | 87 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-01-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Alzheimer Disease Cerebrospinal Fluid Biosensing Techniques Methods Brain Chemistry Copper Analysis Electrochemical Techniques Ionic Liquids Chemistry Pathology Animals Catalysis Electrodes Limit Of Detection Neurokinin B Rats Evaluation Studies Journal Article Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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