NDLI: Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

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Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

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Domain communication in the dynamical structure of human immunodeficiency virus 1 protease.

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Lovastatin decreases coenzyme Q levels in humans.

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Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Moss, B. Weinstein, J. N. Ashorn, P. Fitzgerald, D. J. Pastan, I. Berger, E. A. Chaudhary, V. K.
Description	Author Affiliation: Ashorn P ( Laboratory of Viral Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.);
Abstract	We have previously described a recombinant protein, designated CD4(178)-PE40, consisting of the human immunodeficiency virus (HIV) envelope glycoprotein-binding region of human CD4 linked to the translocation and ADP-ribosylation domains of Pseudomonas aeruginosa exotoxin A. By virtue of its affinity for gp120 (the external subunit of the HIV envelope glycoprotein), the hybrid toxin selectively binds to and kills HIV-1-infected human T cells expressing surface envelope glycoprotein and also inhibits HIV-1 spread in mixed cultures of infected and uninfected cells. We now report that CD4(178)-PE40 and reverse transcriptase inhibitors exert highly synergistic effects against HIV-1 spread in cultured human primary T cells. Furthermore, combination treatment can completely eliminate infectious HIV-1 from cultures of human T-cell lines. This conclusion is based on protection of a susceptible cell population from HIV-induced killing, complete inhibition of virus protein accumulation, and elimination of HIV DNA (as judged by quantitative polymerase chain reaction analysis). The results highlight the therapeutic potential of treatment regimens involving combination of a virostatic drug that inhibits virus replication plus an agent that selectively kills HIV-infected cells.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	ADP Ribose Transferases Antigens, CD4 Chemistry Bacterial Toxins Exotoxins Administration & Dosage HIV Infections Therapy Immunotoxins Reverse Transcriptase Inhibitors T-Lymphocytes Microbiology Virulence Factors Cells, Cultured Didanosine Drug Synergism HIV Growth & Development In Vitro Techniques Virus Replication Drug Effects Zidovudine Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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