NDLI: Evidence for the maintenance of hematopoiesis in a large animal by the sequential activation of stem-cell clones.

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Evidence for the maintenance of hematopoiesis in a large animal by the sequential activation of stem-cell clones.

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Evidence for the maintenance of hematopoiesis in a large animal by the sequential activation of stem-cell clones.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Abkowitz, J. L. Linenberger, M. L. Newton, M. A. Shelton, G. H. Ott, R. L. Guttorp, P.
Description	Author Affiliation: Abkowitz JL ( Department of Medicine, University of Washington, Seattle 98195.);
Abstract	To test if hematopoiesis can be maintained by the sequential activation of stem-cell clones, we performed autologous marrow transplantations with limited numbers of cells in cats heterozygous for the X chromosome-linked enzyme glucose-6-phosphate dehydrogenase (G6PD) and observed the G6PD phenotypes of erythroid and granulocyte/macrophage progenitors over time. The animals were the female offspring of Geoffroy male and domestic female cats. In repeated studies of marrow from control animals (n = 5) or experimental animals prior to transplantation (n = 3), the percent of progenitors with domestic-type G6PD did not vary. After transplantation, the peripheral blood counts, marrow morphologies, frequencies of progenitors, and progenitor cell cycle kinetics returned to normal. However, abrupt and significant fluctuations were seen in the G6PD type of progenitors from each cat during the 1-1.5 years of observation. These data cannot be explained if there were either a large or constant population of active stem cells and thus imply, in a large-animal system, that hematopoiesis was maintained through clonal succession. A stochastic model was developed to estimate the numbers of active clones and their mean lifetimes.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Hematopoiesis Hematopoietic Stem Cells Physiology Animals Bone Marrow Transplantation Cell Division Dosage Compensation, Genetic Glucosephosphate Dehydrogenase Genetics Stochastic Processes Transplantation, Autologous Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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