NDLI: Interindividual concordance of methylation profiles in human genes for tumor necrosis factors alpha and beta.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1990 Volume: 87 Issue: 24

Year: 1990 Volume: 87 Issue: 23

Year: 1990 Volume: 87 Issue: 22

Microtubule dynamics in living dividing plant cells: confocal imaging of microinjected fluorescent brain tubulin.

Incorporation of Paramecium axonemal tubulin into higher plant cells reveals functional sites of microtubule assembly.

Abnormal plant development and down-regulation of phenylpropanoid biosynthesis in transgenic tobacco containing a heterologous phenylalanine ammonia-lyase gene.

Three different mRNAs encoding human granulocyte colony-stimulating factor receptor.

Ligation of membrane immunoglobulin leads to inactivation of the signal-transducing ability of membrane immunoglobulin, CD19, CD21, and B-cell gp95.

Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

Alternative Shaker transcripts express either rapidly inactivating or noninactivating K+ channels.

Allelic loss of chromosomes 16q and 10q in human prostate cancer.

An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors.

Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins.

Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.

The mtr locus is a two-gene operon required for transcription attenuation in the trp operon of Bacillus subtilis.

Incorporation of marine lipids into mitochondrial membranes increases susceptibility to damage by calcium and reactive oxygen species: evidence for enhanced activation of phospholipase A2 in mitochondria enriched with n-3 fatty acids.

Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine.

Synergistic enhancement of globin gene expression by activator protein-1-like proteins.

Cognate peptides induce self-destruction of CD8+ cytolytic T lymphocytes.

Acidic domains around nucleic acids.

Molecular cloning of an olfactory gene from Drosophila melanogaster.

Expression of chicken liver cell adhesion molecule fusion genes in transgenic mice.

Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein.

Reconstitution of simian virus 40 DNA replication with purified proteins.

Changing the invariant proline-30 of rat and Drosophila melanogaster cytochromes c to alanine or valine destabilizes the heme crevice more than the overall conformation.

A DNA gyrase-binding site at the center of the bacteriophage Mu genome is required for efficient replicative transposition.

Evidence for involvement of protein kinase C in the cellular response to interferon alpha.

Purification and characterization of an inhibitor (soluble tumor necrosis factor receptor) for tumor necrosis factor and lymphotoxin obtained from the serum ultrafiltrates of human cancer patients.

Epstein-Barr virus small nuclear RNAs are not expressed in permissively infected cells in AIDS-associated leukoplakia.

Dependence of hormone secretion on activation-inactivation kinetics of voltage-sensitive Ca2+ channels in pituitary gonadotrophs.

Cloning and characterization of a Drosophila serotonin receptor that activates adenylate cyclase.

An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology.

Site-directed mutagenesis of conserved cysteine residues in Escherichia coli fumarate reductase: modification of the spectroscopic and electrochemical properties of the [2Fe-2S] cluster.

Regulation of Cl- transport in T84 cell clones expressing a mutant regulatory subunit of cAMP-dependent protein kinase.

Rabbit ileal villus cell brush border Na+/H+ exchange is regulated by Ca2+/calmodulin-dependent protein kinase II, a brush border membrane protein.

Nerve growth factor potentiates the neurotoxicity of beta amyloid.

Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase.

Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.

Leucine-rich repeats and carboxyl terminus are required for interaction of yeast adenylate cyclase with RAS proteins.

Mutations in genetic variants of human serum albumin found in Italy.

Filler DNA is associated with spontaneous deletions in maize.

Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.

Effects on adaptedness of variations in ribosomal DNA copy number in populations of wild barley (Hordeum vulgare ssp. spontaneum).

Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector.

Analysis of gene families encoding acidic and basic beta-1,3-glucanases of tobacco.

Developmentally regulated expression of an exon containing a stop codon in the gene for glutamic acid decarboxylase.

Mutations in the DET1 gene affect cell-type-specific expression of light-regulated genes and chloroplast development in Arabidopsis.

Sustained vortex-like waves in normal isolated ventricular muscle.

Biosynthesis of vitamin B12: isolation of precorrin-6x, a metal-free precursor of the corrin macrocycle retaining five S-adenosylmethionine-derived peripheral methyl groups.

Biosynthesis of vitamin B12: structure of precorrin-6x octamethyl ester.

X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.

Cytokinin-induced mRNAs in cultured soybean cells.

Interindividual concordance of methylation profiles in human genes for tumor necrosis factors alpha and beta.

Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues.

Isolation of human T-cell lymphotropic virus type 2 from Guaymi Indians in Panama.

Nucleotide sequence and expression of a deep-sea ribulose-1,5-bisphosphate carboxylase gene cloned from a chemoautotrophic bacterial endosymbiont.

Identification of amino acids inserted during suppression of UAA and UGA termination codons at the gag-pol junction of Moloney murine leukemia virus.

Domain communication in the dynamical structure of human immunodeficiency virus 1 protease.

Cultured normal human hepatocytes do not synthesize lipoprotein-associated coagulation inhibitor: evidence that endothelium is the principal site of its synthesis.

Molecular cloning of complementary DNAs encoding two cationic peroxidases from cultivated peanut cells.

A spliced leader is present on a subset of mRNAs from the human parasite Schistosoma mansoni.

Systemic movement of an RNA plant virus determined by a point substitution in a 5' leader sequence.

Bathoiodopsin, a primary intermediate of iodopsin at physiological temperature.

Putative tyrosine kinases expressed in K-562 human leukemia cells.

Differential intron loss and endosymbiotic transfer of chloroplast glyceraldehyde-3-phosphate dehydrogenase genes to the nucleus.

Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay.

Lovastatin decreases coenzyme Q levels in rats.

Lovastatin decreases coenzyme Q levels in humans.

Oscillatory activity of single units in a somatosensory cortex of an awake monkey and their possible role in texture analysis.

Effects of gamma-aminobutyric acid on skate retinal horizontal cells: evidence for an electrogenic uptake mechanism.

Expression of the archaebacterial bacterio-opsin gene with and without signal sequences in Escherichia coli: the expressed proteins are located in the membrane but bind retinal poorly.

Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes.

Acylation-stimulatory activity in hyperapobetalipoproteinemic fibroblasts: enhanced cholesterol esterification with another serum basic protein, BP II.

Sequence-specific interaction of Tat protein and Tat peptides with the transactivation-responsive sequence element of human immunodeficiency virus type 1 in vitro.

Exon trapping: a genetic screen to identify candidate transcribed sequences in cloned mammalian genomic DNA.

Site and strand specificity of UVB mutagenesis in the SUP4-o gene of yeast.

Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth factor: role in vascular disease of diabetes and aging.

Aluminum access to the brain: a role for transferrin and its receptor.

Xenopus Y-box transcription factors: molecular cloning, functional analysis and developmental regulation.

Overexpression of normal and mutated forms of HRAS induces orthotopic bladder invasion in a human transitional cell carcinoma.

Evidence for the maintenance of hematopoiesis in a large animal by the sequential activation of stem-cell clones.

Immunological studies of the basis for the apathogenicity of simian immunodeficiency virus from African green monkeys.

Year: 1990 Volume: 87 Issue: 21

Year: 1990 Volume: 87 Issue: 20

Year: 1990 Volume: 87 Issue: 19

Year: 1990 Volume: 87 Issue: 18

Year: 1990 Volume: 87 Issue: 17

Year: 1990 Volume: 87 Issue: 16

Year: 1990 Volume: 87 Issue: 15

Year: 1990 Volume: 87 Issue: 14

Year: 1990 Volume: 87 Issue: 13

Year: 1990 Volume: 87 Issue: 12

Year: 1990 Volume: 87 Issue: 11

Year: 1990 Volume: 87 Issue: 10

Year: 1990 Volume: 87 Issue: 9

Year: 1990 Volume: 87 Issue: 8

Year: 1990 Volume: 87 Issue: 7

Year: 1990 Volume: 87 Issue: 6

Year: 1990 Volume: 87 Issue: 5

Year: 1990 Volume: 87 Issue: 4

Year: 1990 Volume: 87 Issue: 3

Year: 1990 Volume: 87 Issue: 2

Year: 1990 Volume: 87 Issue: 1

Year: 1990 Volume: 87 Issue: Suppl

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Interindividual concordance of methylation profiles in human genes for tumor necrosis factors alpha and beta.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kochanek, S. Toth, M. Renz, D. Dehmel, A. Doerfler, W.
Description	Author Affiliation: Kochanek S ( University for Genetics, University of Cologne, Germany.);
Abstract	The DNA in mammalian genomes is characterized by complex patterns of DNA methylation that reflect the states of all genetic activities of that genome. The modified nucleotide 5-methyldeoxycytidine (5mdC) can affect the interactions of specific proteins with DNA sequence motifs. The most extensively studied effect of sequence-specific methylations is that of the long-term silencing of eukaryotic (mammalian) promoters. We have initiated studies on the methylation status of parts of the human genome to view patterns of DNA methylation as indicators for genetic activities. In this report, analyses using both restriction enzyme--Southern blotting and the very precise genomic sequencing technique have been done. The genes for tumor necrosis factors (TNF) alpha and beta--in particular, their 5'-upstream and promoter regions--have been investigated in DNA isolated from human lymphocytes, granulocytes, and sperm. The results are characterized by a remarkable interindividual concordance of DNA methylation in specific human cell types. The patterns are identical in the DNA from one cell type for different individuals even of different genetic origins but different in the DNA from different cell types. As an example, in the DNA from human granulocytes of 15 different individuals (ages 20-48 yr, both sexes), 5mdC residues have been localized by the genomic sequencing technique in three identical sequence positions in the 5'-upstream region and in one downstream position of the gene encoding TNF-alpha. The promoter of this gene is free of 5mdC, and TNF-alpha is expressed in human granulocytes. The TNF-beta promoter is methylated in granulocytes from 9 different individuals, and TNF-beta is not expressed. In human lymphocytes, the main source of TNF-beta, the TNF-beta promoter is free of 5mdC residues. All 5'-CG-3' sites studied in the TNF-alpha and -beta genes are methylated in DNA from human sperm. In human cell lines HL-60, Jurkat, and RPMI 1788, the extent of DNA methylation in TNF-alpha and -beta genes has also been studied.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytosine Analogs & Derivatives Lymphotoxin-alpha Genetics Tumor Necrosis Factor-alpha 5-Methylcytosine Cell Line Metabolism Genes Granulocytes Physiology Methylation Promoter Regions, Genetic Restriction Mapping Transcription, Genetic Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in