NDLI: Allelic loss of chromosomes 16q and 10q in human prostate cancer.

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Microtubule dynamics in living dividing plant cells: confocal imaging of microinjected fluorescent brain tubulin.

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Allelic loss of chromosomes 16q and 10q in human prostate cancer.

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Molecular cloning of an olfactory gene from Drosophila melanogaster.

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Reconstitution of simian virus 40 DNA replication with purified proteins.

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A DNA gyrase-binding site at the center of the bacteriophage Mu genome is required for efficient replicative transposition.

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Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues.

Isolation of human T-cell lymphotropic virus type 2 from Guaymi Indians in Panama.

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Identification of amino acids inserted during suppression of UAA and UGA termination codons at the gag-pol junction of Moloney murine leukemia virus.

Domain communication in the dynamical structure of human immunodeficiency virus 1 protease.

Cultured normal human hepatocytes do not synthesize lipoprotein-associated coagulation inhibitor: evidence that endothelium is the principal site of its synthesis.

Molecular cloning of complementary DNAs encoding two cationic peroxidases from cultivated peanut cells.

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Systemic movement of an RNA plant virus determined by a point substitution in a 5' leader sequence.

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Putative tyrosine kinases expressed in K-562 human leukemia cells.

Differential intron loss and endosymbiotic transfer of chloroplast glyceraldehyde-3-phosphate dehydrogenase genes to the nucleus.

Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay.

Lovastatin decreases coenzyme Q levels in rats.

Lovastatin decreases coenzyme Q levels in humans.

Oscillatory activity of single units in a somatosensory cortex of an awake monkey and their possible role in texture analysis.

Effects of gamma-aminobutyric acid on skate retinal horizontal cells: evidence for an electrogenic uptake mechanism.

Expression of the archaebacterial bacterio-opsin gene with and without signal sequences in Escherichia coli: the expressed proteins are located in the membrane but bind retinal poorly.

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Immunological studies of the basis for the apathogenicity of simian immunodeficiency virus from African green monkeys.

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Allelic loss of chromosomes 16q and 10q in human prostate cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ewing, C. M. Aalders, T. W. Schalken, J. A. Epstein, J. I. Isaacs, W. B. Ward, W. S. Carter, B. S. Treiger, B. F.
Description	Author Affiliation: Carter BS ( Brady Urological Institute Research Laboratory, Johns Hopkins Medical Institutions, Baltimore, MD 21205.);
Abstract	Recent advances in understanding the molecular genetics of common adult tumors have indicated that multiple genetic alterations including the activation of oncogenes and the inactivation of tumor suppressor genes are important in the pathogenesis of these tumors. Loss of heterozygosity is a hallmark of tumor suppressor gene inactivation and has been used to identify chromosomal regions that contain these genes. We have examined allelic loss in the most common tumor in men, prostate cancer. Twenty-eight prostate cancer specimens have been examined for loss of heterozygosity at 11 different chromosomal arms including 3p, 7q, 9q, 10p, 10q, 11p, 13q, 16p, 16q, 17p, and 18q. Fifty-four percent (13/24) of clinically localized tumors and 4 of 4 metastatic tumors showed loss of heterozygosity on at least one chromosome. Chromosomes 16q and 10q exhibited the highest frequency of loss of heterozygosity with 30% of tumors showing loss at these chromosomes. These data demonstrate that allelic loss is a common event in prostate cancer and suggest that chromosomes 16q and 10q may contain the sites of tumor suppressor genes important in the pathogenesis of human prostate cancer.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 16 Prostatic Neoplasms Genetics Alleles Blotting, Southern Chromosome Deletion Chromosome Mapping DNA Probes Genes, Tumor Suppressor Polymorphism, Restriction Fragment Length Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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