NDLI: Synergistic enhancement of globin gene expression by activator protein-1-like proteins.

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Synergistic enhancement of globin gene expression by activator protein-1-like proteins.

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Synergistic enhancement of globin gene expression by activator protein-1-like proteins.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Moi, P. Kan, Y. W.
Description	Author Affiliation: Moi P ( Department of Laboratory Medicine, University of California, San Francisco 94143-0724.);
Abstract	DNA sequences corresponding to the four major DNase I hypersensitive sites upstream of the beta-globin gene cluster are essential for the achievement of high levels of globin gene expression and development regulation. In this study, we focused on one of these sites, hypersensitive site 2, which behaves as a powerful enhancer in transient expression and transgenic mouse experiments. We identified a tandem repeat of the activator protein 1 (AP-1) consensus sequence that binds AP-1-like proteins from nuclear extracts of K562 and HeLa cells. These proteins have the same binding properties as HeLa AP-1 but differ in the electrophoretic mobility and in functional assays. Transient-expression experiments in K562 of various deletion and point mutation constructs derived from hypersensitive site 2 indicate that the enhancer activity and the inducibility of a linked gamma-globin promoter are dependent upon the synergistic action of proteins bound to the tandem AP-1 repeat.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Expression Regulation Globins Genetics Regulatory Sequences, Nucleic Acid Binding Sites Binding, Competitive Cell Line DNA Mutational Analysis DNA-Binding Proteins Metabolism Physiology Deoxyribonuclease I Pharmacology Enhancer Elements, Genetic Hemin Molecular Sequence Data Oligonucleotides Proto-Oncogene Proteins C-jun Repetitive Sequences, Nucleic Acid Transcription Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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