NDLI: Identification of amino acids inserted during suppression of UAA and UGA termination codons at the gag-pol junction of Moloney murine leukemia virus.

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Identification of amino acids inserted during suppression of UAA and UGA termination codons at the gag-pol junction of Moloney murine leukemia virus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Feng, Y. X. Rein, A. Oroszlan, S. Copeland, T. D. Levin, J. G.
Description	Author Affiliation: Feng YX ( Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.);
Abstract	Expression of the murine leukemia virus pol gene occurs by translational readthrough of an in-frame UAG codon between the gag and pol coding regions. In a previous study, we mutated the UAG codon to UAA or UGA and demonstrated that both of these termination codons could be suppressed in reticulocyte lysates and in infected cells with the same efficiency as UAG. We now report the identity of the amino acids inserted in vitro in response to UAA and UGA in fusion products containing the gag-pol junction region. The results show that UAA, like UAG, directs the incorporation of glutamine, whereas UGA directs the incorporation of three amino acids, arginine, cysteine, and tryptophan. To our knowledge, this is the first report indicating misreading of UAA as glutamine and UGA as arginine and cysteine in higher eukaryotes. Interestingly, although our protein synthesis system presumably contains other known UAG and UGA suppressors, these tRNAs did not suppress the termination codons in our experiments. Thus, it seems possible that the sequence surrounding the gag-pol junction not only promotes suppression but also helps determine which tRNAs function in suppression.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Moloney Murine Leukemia Virus Genetics Peptide Chain Termination, Translational Amino Acid Sequence Arginine Codon Cysteine Gene Products, Gag Gene Products, Pol Genes, Suppressor Glutamine Molecular Sequence Data Protein Biosynthesis RNA, Transfer Tryptophan Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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