NDLI: A DNA gyrase-binding site at the center of the bacteriophage Mu genome is required for efficient replicative transposition.

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A DNA gyrase-binding site at the center of the bacteriophage Mu genome is required for efficient replicative transposition.

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A DNA gyrase-binding site at the center of the bacteriophage Mu genome is required for efficient replicative transposition.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pato, M. L. Higgins, N. P. Howe, M. M.
Description	Author Affiliation: Pato ML ( Department of Microbiology and Immunology, University of Colorado Health Sciences Center, Denver 80262.);
Abstract	We have discovered a centrally located site that is required for efficient replication of bacteriophage Mu DNA and identified it as a strong DNA gyrase-binding site. Incubation of Mu DNA with gyrase and enoxacin revealed a cleavage site 18.1 kilobases from the left end of the 37.2-kilobase genome. Two observations indicate a role for the site in Mu replication: mutants of Mu, able to grow on an Escherichia coli gyrB host that does not allow growth of wild-type Mu, were found to possess single-base changes resulting in more efficient gyrase binding and cleavage at the site. Introduction of a 147-base-pair deletion that eliminated the site from a prophage inhibited the onset of Mu replication for greater than 1 hr after induction.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bacteriophage Mu Genetics DNA Topoisomerases, Type II Metabolism DNA Transposable Elements Binding Sites DNA Replication DNA, Superhelical Physiology DNA, Viral Molecular Sequence Data Mutation Restriction Mapping Virus Replication Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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