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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Spector, Myron Dorval Courchesne, Noémie-manuelle Shah, Nisarg J. Hyder, Md Nasim Quadir, Mohiuddin A. Seeherman, Howard J. Nevins, Myron Hammond, Paula T. |
| Description | Author Affiliation: Shah NJ ( Department of Chemical Engineering and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139); Hyder MN ( Department of Chemical Engineering and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139); Quadir MA ( Department of Chemical Engineering and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139); Dorval Courchesne NM ( Department of Chemical Engineering and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139); Seeherman HJ ( Restituo LLC, Cambridge, MA 02138); Nevins M ( Department of Oral Medicine, Infection and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Boston, MA 02115); Spector M ( Tissue Engineering Laboratories, Veterans Affairs Boston Healthcare System, Boston, MA 02130); Hammond PT ( Department of Chemical Engineering and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139); |
| Abstract | Traumatic wounds and congenital defects that require large-scale bone tissue repair have few successful clinical therapies, particularly for craniomaxillofacial defects. Although bioactive materials have demonstrated alternative approaches to tissue repair, an optimized materials system for reproducible, safe, and targeted repair remains elusive. We hypothesized that controlled, rapid bone formation in large, critical-size defects could be induced by simultaneously delivering multiple biological growth factors to the site of the wound. Here, we report an approach for bone repair using a polyelectrolye multilayer coating carrying as little as 200 ng of bone morphogenetic protein-2 and platelet-derived growth factor-BB that were eluted over readily adapted time scales to induce rapid bone repair. Based on electrostatic interactions between the polymer multilayers and growth factors alone, we sustained mitogenic and osteogenic signals with these growth factors in an easily tunable and controlled manner to direct endogenous cell function. To prove the role of this adaptive release system, we applied the polyelectrolyte coating on a well-studied biodegradable poly(lactic-co-glycolic acid) support membrane. The released growth factors directed cellular processes to induce bone repair in a critical-size rat calvaria model. The released growth factors promoted local bone formation that bridged a critical-size defect in the calvaria as early as 2 wk after implantation. Mature, mechanically competent bone regenerated the native calvaria form. Such an approach could be clinically useful and has significant benefits as a synthetic, off-the-shelf, cell-free option for bone tissue repair and restoration. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 35 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Bone Morphogenetic Protein 2 Pharmacology Bone Regeneration Drug Effects Proto-Oncogene Proteins C-sis Regenerative Medicine Skull Wound Healing Alendronate Angiogenesis Inducing Agents Animals Biocompatible Materials Bone Density Conservation Agents Bone And Bones Disease Models, Animal Lactic Acid Membranes, Artificial Polyglycolic Acid Rats, Sprague-Dawley Injuries Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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