NDLI: The effect of NELL1 and bone morphogenetic protein-2 on calvarial bone regeneration.

Please wait, while we are loading the content...

Influence of primary and secondary closure of surgical wound after impacted mandibular third molar removal on postoperative pain and swelling--a comparative and split mouth study.

Sialoendoscopic secondary intervention after failure of open sialolithectomy.

Use of therapeutic laser after surgical removal of impacted lower third molars.

Third molars and periodontal pathology in American adolescents and young adults: a prevalence study.

A randomized clinical evaluation of ultrasound bone surgery versus traditional rotary instruments in lower third molar extraction.

The nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in dental implant patients: a South Australian case series.

Single-dose versus single-day antibiotic prophylaxis for orthognathic surgery: a prospective, randomized, double-blind clinical study.

Combined external lithotripsy and endoscopic techniques for advanced sialolithiasis cases.

Three-dimensional computed tomographic analysis of airway anatomy in patients with obstructive sleep apnea.

Three-dimensional computed tomographic analysis of airway anatomy.

Stability of Le Fort I osteotomy in bimaxillary osteotomies: single-piece versus 3-piece maxilla.

The changing personal and professional characteristics of women in oral and maxillofacial surgery.

Prolonged recovery associated with dexmedetomidine when used as a sole sedative agent in office-based oral and maxillofacial surgery procedures.

Simultaneous immediate loading of implants and occlusal rehabilitation: a sophisticated treatment approach.

Feasibility study of a partially hollow configuration for zirconia dental implants.

Use of tilted implants in treatment of the atrophic posterior mandible: a preliminary report of a novel approach.

Influence of diameter and length of implant on early dental implant failure.

Biomechanical comparison of biomimetically and electrochemically deposited hydroxyapatite-coated porous titanium implants.

Screw 'tent-pole' grafting technique for reconstruction of large vertical alveolar ridge defects using human mineralized allograft for implant site preparation.

Anterior mandibular swelling.

Staged removal of horizontally impacted third molars to reduce risk of inferior alveolar nerve injury.

Central adenoid cystic carcinoma of the mandible with multiple bone metastases: case report.

Epidermal choristoma of the oral cavity: report of 2 cases of an extremely rare entity.

Oral manifestations in Ellis-van Creveld syndrome: report of a case and review of the literature.

Retrobulbar hematoma after third molar extraction: case report and review.

Pathogenesis and diverse histologic findings of sialolithiasis in minor salivary glands.

Hybrid odontogenic tumor with features of ameloblastic fibro-odontoma, calcifying odontogenic cyst, and adenomatoid odontogenic tumor: a case report and review of the literature.

Cervicofacial cavernous venous malformation with massive macroglossia: novel surgical treatment with harmonic scalpel.

Retrieval of a displaced third molar using navigation and active image guidance.

CTX and its role in managing patients exposed to oral bisphosphonates.

Staphylococcus species bacteria in oral cavity: a potential risk for prosthetic hips and knees.

Inter-radicular adenomatoid odontogenic tumor of the anterior mandible.

The past, present, and future of oral and maxillofacial surgery--some details in Europe.

Year: 2010 Volume: 68 Issue: 1

Year: 2009 Volume: 67

Year: 2008 Volume: 66

Year: 2007 Volume: 65

Year: 2006 Volume: 64

Year: 2005 Volume: 63

The effect of NELL1 and bone morphogenetic protein-2 on calvarial bone regeneration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Aghaloo, Tara Cowan, Catherine M. Zhang, Xinli Freymiller, Earl Soo, Chia Wu, Benjamin Ting, Kang Zhang, Zhiyuan
Description	Country affiliation: United States Author Affiliation: Aghaloo T ( Dental and Craniofacial Research Institute and Section of Oral and Maxillofacial Surgery, School of Dentistry, University of California, Los Angeles, CA, USA.)
Abstract	PURPOSE: Most craniofacial birth defects contain skeletal components that require bone grafting. Although many growth factors have shown potential for use in bone regeneration, bone morphogenetic proteins (BMPs) are the most osteoinductive. However, supraphysiologic doses, high cost, and potential adverse effects stimulate clinicians and researchers to identify complementary molecules that allow a reduction in dose of BMP-2. Because NELL1 plays a key role as a regulator of craniofacial skeletal morphogenesis, especially in committed chondrogenic and osteogenic differentiation, and a previous synergistic mechanism has been identified, NELL1 is an ideal molecule for combination with BMP-2 in calvarial defect regeneration. We investigated the effect of NELL1 and BMP-2 on bone regeneration in vivo. MATERIALS AND METHODS: BMP-2 doses of 589 and 1,178 ng were grafted into 5-mm critical-sized rat calvarial defects, as compared with 589 ng of NELL1 plus 589 ng of BMP-2 and 1,178 ng of NELL1 plus 1,178 ng of BMP-2, and bone regeneration was analyzed. RESULTS: Live micro-computed tomography data showed increased bone formation throughout 4 to 8 weeks in all groups but a significant improvement when the lower doses of each molecule were combined. High-resolution micro-computed tomography and histology showed more mature and complete defect healing when the combination of NELL1 plus BMP-2 was compared with BMP-2 alone at lower doses. CONCLUSION: The observed potential synergy has significant value in the future treatment of patients with craniofacial defects requiring extensive bone grafting that would normally entail extraoral autogenous bone grafts or doses of BMP-2 in milligrams.
File Format	HTM / HTML
ISSN	02782391
e-ISSN	15315053
DOI	10.1016/j.joms.2009.03.066
Journal	Journal of Oral and Maxillofacial Surgery
Issue Number	2
Volume Number	68
Language	English
Publisher	Elsevier
Publisher Date	2010-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Medicine__semicolon__otorhinolaryngology__semicolon__surgery Bone Morphogenetic Proteins Pharmacology Bone Regeneration Drug Effects Nerve Tissue Proteins Recombinant Proteins Transforming Growth Factor Beta Animals Bone Morphogenetic Protein 2 Administration & Dosage Dose-response Relationship, Drug Drug Carriers Drug Synergism Lactic Acid Polyglycolic Acid Rats, Sprague-dawley Skull Surgery X-ray Microtomography Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Oral Surgery Otorhinolaryngology Surgery

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Synergistic enhancement of new bone formation by recombinant human bone morphogenetic protein-2 and osteoprotegerin in trans-sutural distraction osteogenesis: a pilot study in dogs.

BMP-2-based repair of large-scale calvarial defects in an experimental model: regenerative surgery in cranioplasty.

The Effect of NELL1 and Bone Morphogenetic Protein-2 on Calvarial Bone Regeneration

Bone formation of Escherichia coli expressed rhBMP-2 on absorbable collagen block in rat calvarial defects.

Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 in rat calvarial defects.

Salicylic Acid-Based Polymers for Guided Bone Regeneration Using Bone Morphogenetic Protein-2.

Orthotopic bone formation by implantation of apatite-coated poly(lactide-co-glycolide)/hydroxyapatite composite particulates and bone morphogenetic protein-2.

Evaluation of nanostructure and microstructure of bone regenerated by BMP-2-porous scaffolds.

Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology.

The effect of NELL1 and bone morphogenetic protein-2 on calvarial bone regeneration.

Similar Documents

Synergistic enhancement of new bone formation by recombinant human bone morphogenetic protein-2 and osteoprotegerin in trans-sutural distraction osteogenesis: a pilot study in dogs.

BMP-2-based repair of large-scale calvarial defects in an experimental model: regenerative surgery in cranioplasty.

The Effect of NELL1 and Bone Morphogenetic Protein-2 on Calvarial Bone Regeneration

Bone formation of Escherichia coli expressed rhBMP-2 on absorbable collagen block in rat calvarial defects.

Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 in rat calvarial defects.

Salicylic Acid-Based Polymers for Guided Bone Regeneration Using Bone Morphogenetic Protein-2.

Orthotopic bone formation by implantation of apatite-coated poly(lactide-co-glycolide)/hydroxyapatite composite particulates and bone morphogenetic protein-2.

Evaluation of nanostructure and microstructure of bone regenerated by BMP-2-porous scaffolds.

Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology.

The effect of NELL1 and bone morphogenetic protein-2 on calvarial bone regeneration.