NDLI: Repair of rat cranial bone defect by using bone morphogenetic protein-2-related peptide combined with microspheres composed of polylactic acid/polyglycolic acid copolymer and chitosan.

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Repair of rat cranial bone defect by using bone morphogenetic protein-2-related peptide combined with microspheres composed of polylactic acid/polyglycolic acid copolymer and chitosan.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Jingfeng Jin, Lin Wang, Mingbo Zhu, Shaobo Xu, Shuyun
Description	Author Affiliation: Li J ( Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, 430071, People's Republic of China.)
Abstract	The effects of the transplanted bone morphogenetic protein-2 (BMP2) -related peptide P24 and rhBMP2 combined with poly(lactic-co-glycolic acid) (PLGA)/chitosan (CS) microspheres were investigated in promoting the repair of rat cranial bone defect. Forty white rats were selected and equally divided into four groups (group A: 1 µg of rhBMP2/PLGA/CS composite; group B: 3 mg of P24/PLGA/CS composite; group C: 0.5 µg of rhBMP2 + 1.5 mg of P24/PLGA/CS composite; group D: blank PLGA/CS material), and rat cranial bone defect models with a diameter of 5 mm were established. The materials were transplanted to the cranial bone defects. The animals were sacrificed on weeks 6 and 12 post-operation. Radiographic examinations (x-ray imaging and 3D CT scanning) and histological evaluations were performed. The repaired areas of cranial bone defects were measured, and the osteogenetic abilities of various materials were compared. Cranial histology, imaging, and repaired area measurements showed that the osteogenetic effects at two time points (weeks 6 and 12) in group C were better than those in groups A and B. The effects in groups A and B were similar. Group D achieved the worst repair effect of cranial bone defects, where a large number of fibrous connective tissues were observed. The PLGA/CS composite microspheres loaded with rhBMP2 and P24 had optimal concrescence and could mutually increase their osteogenesis capability. rhBMP2 + P24/PLGA/CS composite is a novel material for bone defect repair with stable activity to induce bone formation.
File Format	HTM / HTML
ISSN	17486041
e-ISSN	1748605X
Journal	Biomedical Materials
Issue Number	4
Volume Number	10
Language	English
Publisher	IOP Publishing
Publisher Date	2015-07-08
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Biomedical Engineering Bone Morphogenetic Protein 2 Administration & Dosage Capsules Chemical Synthesis Chitosan Chemistry Lactic Acid Polyglycolic Acid Polymers Skull Fractures Drug Therapy Animals Bone Substitutes Delayed-action Preparations Fracture Healing Physiology Polyesters Rats, Sprague-dawley Diagnosis Physiopathology Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Chemistry Business and International Management Mechanics of Materials Biomaterials Bioengineering Biomedical Engineering

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